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Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor
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    Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor
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    Journal of Medicinal Chemistry

    Cite this: J. Med. Chem. 2004, 47, 6, 1319–1321
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    https://doi.org/10.1021/jm034248l
    Published February 11, 2004
    Copyright © 2004 American Chemical Society

    Abstract

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    N,N‘-Diarylureas were prepared, and the structure−activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active both in vitro against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.

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     To whom correspondence should be addressed. Phone:  610-270-7831. Fax:  610-270-4451. E-mail:  [email protected].

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    Experimental procedures for the preparation of ureas 1ah. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Journal of Medicinal Chemistry

    Cite this: J. Med. Chem. 2004, 47, 6, 1319–1321
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jm034248l
    Published February 11, 2004
    Copyright © 2004 American Chemical Society

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