ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
Recently Viewed
You have not visited any articles yet, Please visit some articles to see contents here.

Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells

View Author Information
Department of Chemistry, University of Pune, Pune 411007, India, Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 East Canfield Avenue, Detroit, Michigan 48201, Vlife Science Technologies Pvt Ltd., 1 Akshay Residency, Plot No. 50 Anand Park, Aundh Pune 411007, India, and Institute for Inorganic Chemistry, University of Karlsruhe, D-76128 Karlsruhe, Germany
Cite this: J. Med. Chem. 2006, 49, 13, 3800–3808
Publication Date (Web):June 3, 2006
Copyright © 2006 American Chemical Society
Article Views
Read OnlinePDF (359 KB)
Supporting Info (1)»


Abstract Image

The synthesis and characterization of Schiff base derivatives of 3-formylchromone 36 (FPA-120 to FPA-123), the minimal biologically active structural motif of soy isoflavone, genistein, and their copper(II) complexes 710 (FPA-124 to FPA-127) are reported here. These copper complexes possess distorted square-planar geometries capable of stabilizing Cu2+/Cu+ redox forms. The molecular modeling study revealed that the key interaction of the metal complexes was with amino acids in the pleckstrin homology (PH) and the kinase domain of the PKB (Akt) protein. Copper complex 7 significantly forms stronger charge interactions in the kinase domain than genistein, leading to better stabilization in the active pocket. In vitro evaluation of copper complexes against hormone-independent and metastatic breast (BT20), prostate (PC-3), and K-ras mutant (COLO 357) and K-ras wild-type (BxPC-3) pancreatic cancer cells revealed that 7 was the most potent compound which exhibited PKB (Akt protein) inhibitory activities and caused NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells. An inverse relationship was observed between IC50 values of the anti-proliferative activities and the Cu2+/Cu+ redox couple for these compounds, which may provide a rapid screen for evaluating the efficacy of active metallodrugs affecting redox-senstitive transcription factors such as NF-κB and its upstream target, the PKB (Akt) pathway, in multiple cancers.

 University of Pune.

 V.A. and F.A. have contributed equally to this work.


 Wayne State University.

 Vlife Science Technologies Pvt Ltd.

 University of Karlsruhe.


 To whom correspondence should be addressed at the Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 715 Hudson Webber Cancer Research Center, 110 E. Warren, Detroit, MI 48201. Phone:  313-576-8327. Fax:  313-576-8389. E-mail:  [email protected]

Supporting Information Available

Jump To

Full experimental information for Schiff base isoflavone derivatives 36 and the metal complexes 710, analytical characterization, and biological experimental assays. This material is available free of charge via the Internet at

Terms & Conditions

Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system:

Cited By

This article is cited by 89 publications.

  1. Yi Gou, MeiRong Chen, Shanhe Li, JunGang Deng, Jinlong Li, GuiHua Fang, Feng Yang, GuoJin Huang. Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer. Journal of Medicinal Chemistry 2021, 64 (9) , 5485-5499.
  2. Radha Bam, Wesley A. Chalifoux. One-Pot Domino Friedel–Crafts Acylation/Annulation between Alkynes and 2-Methoxybenzoyl Chlorides: Synthesis of 2,3-Disubstituted Chromen-4-one Derivatives. The Journal of Organic Chemistry 2018, 83 (17) , 9929-9938.
  3. Alexandra Gaspar, Maria João Matos, Jorge Garrido, Eugenio Uriarte, and Fernanda Borges . Chromone: A Valid Scaffold in Medicinal Chemistry. Chemical Reviews 2014, 114 (9) , 4960-4992.
  4. Yan-Feng Li, Zai-Qun Liu and Xu-Yang Luo. Properties of Synthetic Homoisoflavonoids To Reduce Oxidants and To Protect Linoleic Acid and DNA against Oxidation. Journal of Agricultural and Food Chemistry 2010, 58 (7) , 4126-4131.
  5. Baodui Wang, Chenjie Xu, Jin Xie, Zhengyin Yang and Shouheng Sun. pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles. Journal of the American Chemical Society 2008, 130 (44) , 14436-14437.
  6. Fortune Kohen, Batya Gayer, Tikva Kulik, Veronica Frydman, Nava Nevo, Sara Katzburg, Rona Limor, Orli Sharon, Naftali Stern and Dalia Somjen . Synthesis and Evaluation of the Antiproliferative Activities of Derivatives of Carboxyalkyl Isoflavones linked to N-t-Boc-hexylenediamine. Journal of Medicinal Chemistry 2007, 50 (25) , 6405-6410.
  7. Artur Shariev, Nicole Painter, Vivienne E. Reeve, Nikolas K. Haass, Mark S. Rybchyn, Furkan A. Ince, Rebecca S. Mason, Katie M. Dixon. PTEN: A novel target for vitamin D in melanoma. The Journal of Steroid Biochemistry and Molecular Biology 2022, 218 , 106059.
  8. Salman Khursheed, Sartaj Tabassum, Farukh Arjmand. Comprehensive biological {DNA/RNA binding profile, cleavage &cytotoxicity activity} of structurally well-characterized chromone-appended Cu(II)(L1-3)(phen) potential anticancer drug candidates. Polyhedron 2022, 214 , 115638.
  9. Abdolali Alizadeh, Elham Sanjari, Reza Rezaiyehraad, Mohammad Reza Halvagar. One-pot diastereoselective synthesis of highly functionalized chromenone-substituted 4,5-dihydrofuran via sequential three-component reaction. Journal of the Iranian Chemical Society 2022, 60
  10. Jai Devi, Sanjeev Kumar, Deepak Kumar, Deepak Kumar Jindal, Y. Poornachandra. Synthesis, characterization, in vitro antimicrobial and cytotoxic evaluation of Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from bidentate hydrazones. Research on Chemical Intermediates 2022, 48 (1) , 423-455.
  11. Khushboo Iman, Md Kausar Raza, Mursaleem Ansari, Monika, Azaj Ansari, Musheer Ahmad, M. Naqi Ahamad, Khalil M. A. Qasem, Sameer Hussain, Muhammad Nadeem Akhtar, M. Shahid. Novel {Cu 4 } and {Cu 4 Cd 6 } clusters derived from flexible aminoalcohols: synthesis, characterization, crystal structures, and evaluation of anticancer properties. Dalton Transactions 2021, 50 (34) , 11941-11953.
  12. Jingkun Zeng, Florian Weissmann, Agustina P. Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C. Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S. Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F.X. Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase. Biochemical Journal 2021, 478 (13) , 2405-2423.
  13. Y. Sheena Mary, Y. Shyma Mary, K. S. Resmi, S. Sarala, Rohitash Yadav, Ismail Celik. Modeling the structural and reactivity properties of hydrazono methyl-4H-chromen-4-one derivatives—wavefunction-dependent properties, molecular docking, and dynamics simulation studies. Journal of Molecular Modeling 2021, 27 (6)
  14. Y. Sheena Mary, Y. Shyma Mary, K. S. Resmi, Ali Shokuhi Rad. Spectroscopic and computational study of chromone derivatives with antitumor activity: detailed DFT, QTAIM and docking investigations. SN Applied Sciences 2021, 3 (2)
  15. Siffeen Zehra, Sartaj Tabassum, Farukh Arjmand. Biochemical pathways of copper complexes: progress over the past 5 years. Drug Discovery Today 2021, 19
  16. Farukh Arjmand, Salman khursheed, Thierry Roisnel, Hifzur R. Siddique. Copper (II)-based halogen-substituted chromone antitumor drug entities: Studying biomolecular interactions with ct-DNA mediated by sigma hole formation and cytotoxicity activity. Bioorganic Chemistry 2020, 104 , 104327.
  17. Małgorzata Biedulska, Aleksandra Królicka, Andrea D. Lipińska, Marta Krychowiak-Maśnicka, Michał Pierański, Kinga Grabowska, Dawid Nidzworski. Physicochemical profile of Os (III) complexes with pyrazine derivatives: From solution behavior to DNA binding studies and biological assay. Journal of Molecular Liquids 2020, 316 , 113804.
  18. Narendra Kumar Singh, Anupa A Kumbhar, Yuba Raj Pokharel, Paras Nath Yadav. Anticancer potency of copper(II) complexes of thiosemicarbazones. Journal of Inorganic Biochemistry 2020, 210 , 111134.
  19. Valentina Uivarosi, Alexandra Cristina Munteanu, Ajay Sharma, Hardeep Singh Tuli. Metal Complexation and Patent Studies of Flavonoid. 2019,,, 39-89.
  20. Farukh Arjmand, Zeenat Afsan, Thierry Roisnel. Design, synthesis and characterization of novel chromone based-copper( ii ) antitumor agents with N , N -donor ligands: comparative DNA/RNA binding profile and cytotoxicity. RSC Advances 2018, 8 (65) , 37375-37390.
  21. Yasser M. A. Mohamed, Eirik Johansson Solum, Ahmad F. Eweas. Synthesis, antibacterial evaluation, and docking studies of azaisoflavone analogues generated by palladium-catalyzed cross coupling. Monatshefte für Chemie - Chemical Monthly 2018, 149 (10) , 1857-1864.
  22. Jhi Biau Foo, May Lee Low, Ji Hui Lim, Yan Zhi Lor, Rusyidah Zainol Abidin, Vilasini Eh Dam, Napsiah Abdul Rahman, Chaw Yee Beh, Lee Chin Chan, Chee Wun How, Yin Sim Tor, Latifah Saiful Yazan. Copper complex derived from S-benzyldithiocarbazate and 3-acetylcoumarin induced apoptosis in breast cancer cell. BioMetals 2018, 31 (4) , 505-515.
  23. Mayuri Bheemarasetti, Kavitha Palakuri, Shweta Raj, Prakash Saudagar, Durgaiah Gandamalla, Narsimha Reddy Yellu, Laxma Reddy Kotha. Novel Schiff base metal complexes: synthesis, characterization, DNA binding, DNA cleavage and molecular docking studies. Journal of the Iranian Chemical Society 2018, 15 (6) , 1377-1389.
  24. E. Sneha Jose, Jessica Elizabeth Philip, A.A. Shanty, M.R.P. Kurup, P.V. Mohanan. Novel class of mononuclear 2-methoxy-4-chromanones ligated Cu (II), Zn (II), Ni (II) complexes: synthesis, characterisation and biological studies. Inorganica Chimica Acta 2018, 478 , 155-165.
  25. Sulakshna Bharti, Mukesh Choudhary, Bharti Mohan, S. R. Sharma, K. Ahmad. Syntheses, crystal structures, DFT, molecular docking and inhibition studies of jack been urease by nickel (II) and copper (II) Schiff base complexes. Inorganic and Nano-Metal Chemistry 2018, 48 (4-5) , 211-224.
  26. Alanood S. Algarni, Alan J. Hargreaves, John M. Dickenson. Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: A role in cell survival and neurite outgrowth. European Journal of Pharmacology 2018, 820 , 113-129.
  27. Magdy Shebl, Omima M.I. Adly, A. Taha, N.N. Elabd. Structural variety in copper(II) complexes of 3-formylchromone: Synthesis, spectral, thermal, molecular modeling and biological studies. Journal of Molecular Structure 2017, 1147 , 438-451.
  28. V. G. Vlasenko, L. D. Popov, I. N. Shcherbakov, V. V. Lukov, S. I. Levchenkov, I. V. Pankov, Ya. V. Zubavichus, A. L. Trigub. Local atomic structure of mono- and binuclear metal complexes based on 3-formylpyrone and 3-formylcoumarin bis-azomethines. Journal of Structural Chemistry 2017, 58 (6) , 1226-1235.
  29. Bheemarasetti Mayuri, P. Kavitha, Srinivas Basavoju, G. Bhargavi, K. Laxma Reddy. Synthesis, structural characterisation and biological evolution of chromanones. Journal of Molecular Structure 2017, 1145 , 1-9.
  30. S. Ali Beyramabadi, Bahareh Esmaeili, Azar Gharib, Mahdi Khorsandi-Chenarboo, Ali Morsali, Maryam Khashi, Razieh Sanavi-Khoshnood. Synthesis, experimental and DFT characterization of the 2-((E)-(2-[(E)-2,3-Dihydroxybenzylideneamino]-5-methylphenyl)iminiomethyl)-6-hydroxyphenolate and its Ni(II) and Cu(II) complexes. Journal of Molecular Structure 2017, 1146 , 620-628.
  31. Morteza Dostani, Ali Hossein Kianfar, Wan Ahmad Kamil Mahmood, Mohammad Dinari, Hossein Farrokhpour, Mohammad R. Sabzalian, Fatemeh Abyar, Mohammad Hossein Azarian. An experimental and theoretical study on the interaction of DNA and BSA with novel Ni 2+ , Cu 2+ and VO 2+ complexes derived from vanillin bidentate Schiff base ligand. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2017, 180 , 144-153.
  32. Alanood S. Algarni, Alan J. Hargreaves, John M. Dickenson. Role of transglutaminase 2 in PAC1 receptor mediated protection against hypoxia-induced cell death and neurite outgrowth in differentiating N2a neuroblastoma cells. Biochemical Pharmacology 2017, 128 , 55-73.
  33. Christian David Alcívar León, Gustavo Alberto Echeverría, Oscar Enrique Piro, Sonia Elizabeth Ulic, Jorge Luis Jios, Jaime Andrés Pereañez, Isabel Cristina Henao Castañeda, Hiram Pérez. The role of non-covalent interactions in some 2-trifluoromethylchromones in the solid state. New Journal of Chemistry 2017, 41 (23) , 14659-14674.
  34. S. Sharma, R. Meena, Y. Satyawana, N. Fahmi. Manganese(II) complexes of biological relevance: Synthesis and spectroscopic characterization of novel manganese(II) complexes with monobasic bidentate ligands derived from halo-substituted 1H-indole-2,3-diones. Russian Journal of General Chemistry 2016, 86 (12) , 2807-2816.
  35. Fatima Bousejra-ElGarah, Barbora Lajoie, Jean-Pierre Souchard, Geneviève Baziard, Jalloul Bouajila, Salomé El Hage. Synthesis and evaluation of chromone-2-carboxamide derivatives as cytotoxic agents and 5-lipoxygenase inhibitors. Medicinal Chemistry Research 2016, 25 (11) , 2547-2556.
  36. Emmanuel U. Okoro, Zhongmao Guo, Hong Yang. Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E. Biochemical and Biophysical Research Communications 2016, 477 (1) , 123-128.
  37. Magdy Shebl, M. Saif, Asmaa I. Nabeel, R. Shokry. New non-toxic transition metal nanocomplexes and Zn complex-silica xerogel nanohybrid: Synthesis, spectral studies, antibacterial, and antitumor activities. Journal of Molecular Structure 2016, 1118 , 335-343.
  38. P. Kavitha, K. Laxma Reddy. Synthesis, spectral characterisation, morphology, biological activity and DNA cleavage studies of metal complexes with chromone Schiff base. Arabian Journal of Chemistry 2016, 9 (4) , 596-605.
  39. David Thirkettle-Watts. Impedance-based analysis of mu opioid receptor signaling and underlying mechanisms. Biochemistry and Biophysics Reports 2016, 6 , 32-38.
  40. Jie Wang, Qiao-Li Wang, Xu-Hua Nong, Xiao-Yong Zhang, Xin-Ya Xu, Shu-Hua Qi, Yi-Fei Wang. Oxalicumone A, a new dihydrothiophene-condensed sulfur chromone induces apoptosis in leukemia cells through endoplasmic reticulum stress pathway. European Journal of Pharmacology 2016, 783 , 47-55.
  41. Khadijah Al-Zaydi, Saad M. Alshehri, Taibi Ben Hadda. Structure and POM analyses of 2-{(2Z)-2-[(2R)-2-ethoxy-4-oxo-2H-chromen-3(4H)-ylidene]hydrazinyl}benzonitrile with promising parasitological activity. Research on Chemical Intermediates 2016, 42 (3) , 2201-2210.
  42. Marwa Sayed Salem, Mohamed Ahmed Mohamed Ali. Novel Pyrazolo[3,4-b]pyridine Derivatives: Synthesis, Characterization, Antimicrobial and Antiproliferative Profile. Biological & Pharmaceutical Bulletin 2016, 39 (4) , 473-483.
  43. Chengcai Xia, Yong Yang, Zhenjiang Wei, Wenbo Yu, Hanxiao Liao, Chao Shen, Pengfei Zhang. Palladium-Catalyzed Decarboxylative Csp2–Csp2 Cross-Coupling Reactions: An Efficient Route for Synthesis of Azaisoflavone Derivatives. Catalysis Letters 2015, 145 (8) , 1634-1642.
  44. Tummalapalli Kiran, Vuppalapati Giri Prasanth, M.M. Balamurali, C.S. Vasavi, Punnagai Munusami, Kulathu Iyer Sathiyanarayanan, Madhvesh Pathak. Synthesis, spectroscopic characterization and in vitro studies of new heteroleptic copper (II) complexes derived from 2-hydroxy napthaldehyde Schiff’s bases and N, N donor ligands: Antimicrobial, DNA binding and cytotoxic investigations. Inorganica Chimica Acta 2015, 433 , 26-34.
  45. May Lee Low, Georgiana Paulus, Pierre Dorlet, Régis Guillot, Rozita Rosli, Nicolas Delsuc, Karen A. Crouse, Clotilde Policar. Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin. BioMetals 2015, 28 (3) , 553-566.
  46. Rupesh Chikhale, Sunil Menghani, Ramavath Babu, Ratnadeep Bansode, G. Bhargavi, Nazira Karodia, M.V. Rajasekharan, Anant Paradkar, Pramod Khedekar. Development of selective DprE1 inhibitors: Design, synthesis, crystal structure and antitubercular activity of benzothiazolylpyrimidine-5-carboxamides. European Journal of Medicinal Chemistry 2015, 96 , 30-46.
  47. Karam Chand, Rakesh K Tiwari, Sumit Kumar, Amir Nasrolahi Shirazi, Sweta Sharma, Erik V Van der Eycken, Virinder S Parmar, Keykavous Parang, Sunil K Sharma. Synthesis, Antiproliferative, and c-Src Kinase Inhibitory Activities of 4-Oxo-4 H -1-benzopyran Derivatives. Journal of Heterocyclic Chemistry 2015, 52 (2) , 562-572.
  48. Matsjeh S, Anwar C, Sholikhah E. N, Alimuddin A. A. Synthesis 3,4-Dimethoxybenzyl-2,4-Dihydroxyphenyl Ketone from Eugenol. International Journal of Chemical Engineering and Applications 2015, 6 (1) , 61-65.
  49. Morteza Montazerozohori, Sahar Yadegari, Asghar Naghiha, Ahmad Hojjati. Some New Four Coordinated Hg(II) Complexes: Synthesis, Characterization, Electrochemical Behavior, Antibacterial/Antifungal Properties, and Theoretical Investigation. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 2015, 45 (1) , 48-57.
  50. Kranthi G. Kishore, Unnamatla M.V. Basavanag, Alejandro Islas-Jácome, Rocío Gámez-Montaño. Synthesis of imidazo[1,2-a]pyridin-chromones by a MW assisted Groebke–Blackburn–Bienaymé process. Tetrahedron Letters 2015, 56 (1) , 155-158.
  51. Imtiyaz Yousuf, Farukh Arjmand, Sartaj Tabassum, Loic Toupet, Rais Ahmad Khan, Maqsood Ahmad Siddiqui. Mechanistic insights into a novel chromone-appended Cu( ii ) anticancer drug entity: in vitro binding profile with DNA/RNA substrates and cytotoxic activity against MCF-7 and HepG2 cancer cells. Dalton Transactions 2015, 44 (22) , 10330-10342.
  52. Elham S. Aazam, Waleed Ahmed El-Said. Synthesis of copper/nickel nanoparticles using newly synthesized Schiff-base metals complexes and their cytotoxicity/catalytic activities. Bioorganic Chemistry 2014, 57 , 5-12.
  53. Yijie Zhang, Kailian Zheng, Hongli Yan, Gang Jin, Chenghao Shao, Xuyu Zhou, Yingqi Zhou, Tianlin He. RETRACTED ARTICLE: Growth inhibition and apoptosis induced by 6-fluoro-3-formylchromone in hepatocellular carcinoma. BMC Gastroenterology 2014, 14 (1)
  54. Yan Wang, San Zeng, Tien-Min Lin, Lisa Krugner-Higby, Doug Lyman, Dana Steffen, May P. Xiong. Evaluating the Anticancer Properties of Liposomal Copper in a Nude Xenograft Mouse Model of Human Prostate Cancer: Formulation, In Vitro, In Vivo, Histology and Tissue Distribution Studies. Pharmaceutical Research 2014, 31 (11) , 3106-3119.
  55. Hyo Jin Gim, Hua Li, So Ra Jung, Yong Joo Park, Jae-Ha Ryu, Kyu Hyuck Chung, Raok Jeon. Design and synthesis of azaisoflavone analogs as phytoestrogen mimetics. European Journal of Medicinal Chemistry 2014, 85 , 107-118.
  56. Diana-Carolina Ilies, Elena Pahontu, Sergiu Shova, Rodica Georgescu, Nicolae Stanica, Rodica Olar, Aurelian Gulea, Tudor Rosu. Synthesis, characterization, crystal structure and antimicrobial activity of copper(II) complexes with a thiosemicarbazone derived from 3-formyl-6-methylchromone. Polyhedron 2014, 81 , 123-131.
  57. Pedro A. Cano, Alejandro Islas-Jácome, Joaquín González-Marrero, Lilian Yépez-Mulia, Fernando Calzada, Rocío Gámez-Montaño. Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis. Bioorganic & Medicinal Chemistry 2014, 22 (4) , 1370-1376.
  58. Santosh Rajput, Christopher R. Gardner, Timothy W. Failes, Greg M. Arndt, David StC. Black, Naresh Kumar. Synthesis and anticancer evaluation of 3-substituted quinolin-4-ones and 2,3-dihydroquinolin-4-ones. Bioorganic & Medicinal Chemistry 2014, 22 (1) , 105-115.
  59. Omaima E. Sherif, Nora S. Abdel-Kader. Spectroscopic and biological activities studies of bivalent transition metal complexes of Schiff bases derived from condensation of 1,4-phenylenediamine and benzopyrone derivatives. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014, 117 , 519-526.
  60. N Zareen, S C Biswas, L A Greene. A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons. Cell Death & Differentiation 2013, 20 (12) , 1719-1730.
  61. Agnieszka Dziewulska-Kułaczkowska, Agata Bartyzel. Structural and physicochemical properties of 3-(3-carboxyphenylaminomethylene)-2-methoxychroman-4-one. Journal of Molecular Structure 2013, 1033 , 67-74.
  62. P. Kavitha, M. Saritha, K. Laxma Reddy. Synthesis, structural characterization, fluorescence, antimicrobial, antioxidant and DNA cleavage studies of Cu(II) complexes of formyl chromone Schiff bases. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2013, 102 , 159-168.
  63. Min Hong, Handong Yin, Xiuyun Zhang, Chuan Li, Caihong Yue, Shuang Cheng. Di- and tri-organotin(IV) complexes with 2-hydroxy-1-naphthaldehyde 5-chloro-2-hydroxybenzoylhydrazone: Synthesis, characterization and in vitro antitumor activities. Journal of Organometallic Chemistry 2013, 724 , 23-31.
  64. Rehab M. Amin, Nora S. Abdel-Kader, Aida L. El-Ansary. Microplate assay for screening the antibacterial activity of Schiff bases derived from substituted benzopyran-4-one. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012, 95 , 517-525.
  65. Kong Wai Tan, Hoi Ling Seng, Fei Shen Lim, Shiau-Chuen Cheah, Chew Hee Ng, Kong Soo Koo, Mohd. Rais Mustafa, Seik Weng Ng, Mohd. Jamil Maah. Towards a selective cytotoxic agent for prostate cancer: Interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase I. Polyhedron 2012, 38 (1) , 275-284.
  66. Vimal K. Bhardwaj, Maninder Singh Hundal, Montserrat Corbella, Verónica Gómez, Geeta Hundal. Salicylaldimine Schiff bases – Generation of self-assembled and chiral complexes with Ni(II) and Zn(II) ions. An unusual antiferromagnetic interaction in a triply bridged Ni(II) dimer. Polyhedron 2012, 38 (1) , 224-234.
  67. Magdalena Grażul, Aleksander Kufelnicki, Magdalena Wozniczka, Ingo-Peter Lorenz, Peter Mayer, Andrzej Jóźwiak, Malgorzata Czyz, Elzbieta Budzisz. Synthesis, structure, electrochemical properties, cytotoxic effects and antioxidant activity of 5-amino-8-methyl-4H-benzopyran-4-one and its copper(II) complexes. Polyhedron 2012, 31 (1) , 150-158.
  68. Li-Jun Tang, Xiang Chen, Yu-Na Sun, Jia Ye, Jing Lu, Ying Han, Xing Jiang, Chan-Chan Cheng, Cheng-Cheng He, Pei-Hong Qiu, Xiao-Kun Li. Synthesis and biological studies of 4′, 7, 8-trihydroxy-isoflavone metal complexes. Journal of Inorganic Biochemistry 2011, 105 (12) , 1623-1629.
  69. Huilu Wu, Fei Jia, Fan Kou, Bin Liu, Jingkun Yuan, Ying Bai. A Schiff base N -(2-hydroxylacetophenone)-3-oxapentane-1,5-diamine and its copper(II) coordination polymer: synthesis, crystal structure, antioxidation, and DNA-binding properties. Journal of Coordination Chemistry 2011, 64 (20) , 3454-3464.
  70. Mohammad Shakir, Mohammad Azam, M.F. Ullah, S.M. Hadi. Synthesis, spectroscopic and electrochemical studies of N,N-bis[(E)-2-thienylmethylidene]-1,8-naphthalenediamine and its Cu(II) complex: DNA cleavage and generation of superoxide anion. Journal of Photochemistry and Photobiology B: Biology 2011, 104 (3) , 449-456.
  71. Mark S. Rybchyn, Michael Slater, Arthur D. Conigrave, Rebecca S. Mason. An Akt-dependent Increase in Canonical Wnt Signaling and a Decrease in Sclerostin Protein Levels Are Involved in Strontium Ranelate-induced Osteogenic Effects in Human Osteoblasts. Journal of Biological Chemistry 2011, 286 (27) , 23771-23779.
  72. Y. G. Li, X. W. Dong, R. Ai, X. L. Xu, H. L. Zhu. Synthesis and crystal structure of a new Schiff base ligand and its cobalt(II) complex. Russian Journal of Coordination Chemistry 2011, 37 (7) , 523-527.
  73. Agnieszka Dziewulska-Kułaczkowska, Liliana Mazur. Structural studies and characterization of 3-formylchromone and products of its reactions with chosen primary aromatic amines. Journal of Molecular Structure 2011, 985 (2-3) , 233-242.
  74. Esam A. Orabi. Theoretical study of inner and outer mononuclear complexes of Co(II), Ni(II), and Cu(II) with a compartmental hexadentate Schiff base derived from 3-formylsalicylic acid. Journal of Coordination Chemistry 2010, 63 (22) , 4017-4029.
  75. Jichun Cui, Yanling Qiao, Handong Yin, Ming Liu. Synthesis, Characterization, and Crystal Structure of Dinuclear Diorganotin(IV) Complexes Derived from Pyruvic Acid Picolinoacylhydrazone. Zeitschrift für anorganische und allgemeine Chemie 2010, 636 (13-14) , 2508-2512.
  76. José Linares‐Palomino, Muhammad A. Husainy, Vien K. Lai, John M. Dickenson, Manuel Galiñanes. Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury. The Journal of Physiology 2010, 588 (12) , 2173-2191.
  77. Min Hong, Han-Dong Yin, Shao-Wen Chen, Da-Qi Wang. Synthesis and structural characterization of organotin(IV) compounds derived from the self-assembly of hydrazone Schiff base series and various alkyltin salts. Journal of Organometallic Chemistry 2010, 695 (5) , 653-662.
  78. Kui Cheng, Qing-Zhong Zheng, Hai-Liang Zhu. Syntheses, structures and urease inhibitory activities of mononuclear cobalt(III) and 1D cobalt(II) complexes with ligands derived from 3-formylsalicylic acid. Inorganic Chemistry Communications 2009, 12 (11) , 1116-1119.
  79. Giuseppina Rea, Fabio Polticelli, Amina Antonacci, Viviana Scognamiglio, Prashant Katiyar, Sudhir A. Kulkarni, Udo Johanningmeier, Maria Teresa Giardi. Structure-based design of novel Chlamydomonas reinhardtii D1-D2 photosynthetic proteins for herbicide monitoring. Protein Science 2009, 18 (10) , 2139-2151.
  80. Maria Teresa Giardi, Viviana Scognamiglio, Giuseppina Rea, Giuseppe Rodio, Amina Antonacci, Maya Lambreva, Gianni Pezzotti, Udo Johanningmeier. Optical biosensors for environmental monitoring based on computational and biotechnological tools for engineering the photosynthetic D1 protein of Chlamydomonas reinhardtii. Biosensors and Bioelectronics 2009, 25 (2) , 294-300.
  81. Francesco Tisato, Cristina Marzano, Marina Porchia, Maura Pellei, Carlo Santini. Copper in diseases and treatments, and copper-based anticancer strategies. Medicinal Research Reviews 2009, 186 , n/a-n/a.
  82. Chenjie Xu, Shouheng Sun. Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications. Dalton Transactions 2009, 18 (29) , 5583.
  83. Guo Hua Jin, Sang Keun Ha, Hye Min Park, Bomi Kang, Sun Yeou Kim, Hee-Do Kim, Jae-Ha Ryu, Raok Jeon. Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia. Bioorganic & Medicinal Chemistry Letters 2008, 18 (14) , 4092-4094.
  84. Ming-Yi Lee, Huan-You Lin, Faiwen Cheng, Wenchang Chiang, Yueh-Hsiung Kuo. Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran. Food and Chemical Toxicology 2008, 46 (6) , 1933-1939.
  85. Fazlul H. Sarkar, Yiwei Li. Sensitization of Cancer Cells to Cancer Therapies by Isoflavone and Its Synthetic Derivatives. 2008,,, 327-335.
  86. Michael A. Jakupec, Markus Galanski, Vladimir B. Arion, Christian G. Hartinger, Bernhard K. Keppler. Antitumour metal compounds: more than theme and variations. Dalton Trans. 2008, 3 (2) , 183-194.
  87. Qun Li. Recent progress in the discovery of Akt inhibitors as anticancer agents. Expert Opinion on Therapeutic Patents 2007, 17 (9) , 1077-1130.
  88. Wolfgang F. Schmid, Stefanie Zorbas-Seifried, Roland O. John, Vladimir B. Arion, Michael A. Jakupec, Alexander Roller, Markus Galanski, Ion Chiorescu, Haralabos Zorbas, Bernhard K. Keppler. The First Ruthenium-Based Paullones:  Syntheses, X-ray Diffraction Structures, and Spectroscopic and Antiproliferative Properties in Vitro. Inorganic Chemistry 2007, 46 (9) , 3645-3656.
  89. Dipti Shingnapurkar, Ray Butcher, Zahra Afrasiabi, Ekkhard Sinn, Fakhara Ahmed, Fazlul Sarkar, Subhash Padhye. Neutral dimeric copper–sparfloxacin conjugate having butterfly motif with antiproliferative effects against hormone independent BT20 breast cancer cell line. Inorganic Chemistry Communications 2007, 10 (4) , 459-462.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.