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Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

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Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530
Mylan Pharmaceuticals Inc., 781 Chestnut Ridge Road, Morgantown, West Virginia 26505
§ Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477
*To whom correspondence should be addressed. Phone: (412) 396 6031. Fax: (412) 396 5683. E-mail: [email protected]
Cite this: J. Med. Chem. 2010, 53, 22, 7902–7917
Publication Date (Web):August 30, 2010
Copyright © 2010 American Chemical Society

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    91. Nengneng Zhou, Ziqin Xia, Sixin Wu, Kaimo Kuang, Qiankun Xu, Man Zhang. Visible-Light-Induced Multicomponent Cascade Cycloaddition of N-Propargyl Aromatic Amines, Cyclobutanone Oxime Esters, and K2S2O5: Access to Cyanoalkylsulfonylated Quinolines. The Journal of Organic Chemistry 2021, 86 (21) , 15253-15262.
    92. Yanxin Jiang, Chao Li, Songbai Tang, Shaokun Tao, Maolin Yuan, Ruixiang Li, Hua Chen, Haiyan Fu, Xueli Zheng. Practical Synthesis of (Z)-α,β-Unsaturated Nitriles via a One-Pot Sequential Hydroformylation/Knoevenagel Reaction. The Journal of Organic Chemistry 2021, 86 (21) , 15413-15422.
    93. Xiangqing Jia, Ziyan Zhang, Vladimir Gevorgyan. Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes. ACS Catalysis 2021, 11 (21) , 13217-13222.
    94. Koichi Kodama, Yuki Shimomura, Takuji Hirose. Enantiomer Separation of Nitriles and Epoxides by Crystallization with Chiral Organic Salts: Chirality Switching Modulated by Achiral Acids. Crystal Growth & Design 2021, 21 (11) , 6552-6557.
    95. Jingjing Sang, Li Feng, Rui Hu, Jichao Chen, Dandan Shang, Qing Bao, Weidong Rao. Sc(OTf)3-Catalyzed C2-Selective Cyanation/Defluorination Cascade of Perfluoroalkylated 3-Indolylmethanols and Application to the Synthesis of 3-Fluoro(perfluoroalkyl)-β-carbolines. Organic Letters 2021, 23 (19) , 7666-7671.
    96. Chunxiang Pan, Chunhui Yang, Kangkui Li, Keyang Zhang, Yuanbin Zhu, Shiyuan Wu, Yongyun Zhou, Baomin Fan. Photo-Promoted Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β,γ-Unsaturated Nitriles. Organic Letters 2021, 23 (18) , 7188-7193.
    97. Huanrong Ouyang, Joshua Hong, Jeshua Malroy, Xuejun Zhu. An E. coli-Based Biosynthetic Platform Expands the Structural Diversity of Natural Benzoxazoles. ACS Synthetic Biology 2021, 10 (9) , 2151-2158.
    98. Pravin L Kotian, Minwan Wu, Satish Vadlakonda, Venkat Chintareddy, Pengcheng Lu, Luis Juarez, Debra Kellogg-Yelder, Xilin Chen, Saritha Muppa, Ramanda Chambers-Wilson, Cynthia Davis Parker, Jason Williams, Kevin J Polach, Weihe Zhang, Krishnan Raman, Yarlagadda S Babu. Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE). Journal of Medicinal Chemistry 2021, 64 (17) , 12453-12468.
    99. Xia Zhao, Liangshuo Ji, Yu Gao, Tengteng Sun, Jiamin Qiao, Ankun Li, Kui Lu. Visible-Light-Promoted Selenocyanation of Cyclobutanone Oxime Esters Using Potassium Selenocyanate. The Journal of Organic Chemistry 2021, 86 (17) , 11399-11406.
    100. Jianyu Xu, J. Cameron Twitty, Mary P. Watson. Nickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines. Organic Letters 2021, 23 (16) , 6242-6245.
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