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Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

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Worldwide Medicinal Chemistry and Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
§ Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, Massachusetts 02139, United States
*Phone: (617) 551-3336. E-mail: [email protected]
Cite this: J. Med. Chem. 2012, 55, 11, 4896–4933
Publication Date (Web):March 12, 2012
https://doi.org/10.1021/jm300065h
Copyright © 2012 American Chemical Society

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