Pharmacotherapies for Treatment of Cocaine Abuse: Preclinical Aspects
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*
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‡
Research Triangle Institute.
†
Emory University.
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, 1775-1783. https://doi.org/10.1021/acscentsci.3c00556
- Atsushi Kimishima, Cody J. Wenthur, Lisa M. Eubanks, Shun Sato, and Kim D. Janda . Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors. Molecular Pharmaceutics 2016, 13
(11)
, 3884-3890. https://doi.org/10.1021/acs.molpharmaceut.6b00682
- Jeffrey S. Stehouwer, Lauryn M. Daniel, Ping Chen, Ronald J. Voll, Larry Williams, Susan J. Plott, John R. Votaw, Michael J. Owens, Leonard Howell and Mark M. Goodman . Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. Journal of Medicinal Chemistry 2010, 53
(15)
, 5549-5557. https://doi.org/10.1021/jm100269c
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(21)
, 6768-6781. https://doi.org/10.1021/jm901189z
- Yongmei Pan, Jennifer L. Muzyka and Chang-Guo Zhan. Model of Human Butyrylcholinesterase Tetramer by Homology Modeling and Dynamics Simulation. The Journal of Physical Chemistry B 2009, 113
(18)
, 6543-6552. https://doi.org/10.1021/jp8114995
- Thomas E. Prisinzano. Natural Products as Tools for Neuroscience: Discovery and Development of Novel Agents to Treat Drug Abuse. Journal of Natural Products 2009, 72
(3)
, 581-587. https://doi.org/10.1021/np8005748
- Chunyang Jin, Hernán A. Navarro and F. Ivy Carroll. Development of 3-Phenyltropane Analogues with High Affinity for the Dopamine and Serotonin Transporters and Low Affinity for the Norepinephrine Transporter. Journal of Medicinal Chemistry 2008, 51
(24)
, 8048-8056. https://doi.org/10.1021/jm801162z
- Trudy A. Smith, Xiaowen Yang, Huifang Wu, Buddy Pouw, Rae R. Matsumoto and Andrew Coop. Trifluoromethoxyl Substituted Phenylethylene Diamines as High Affinity σ Receptor Ligands with Potent Anti-Cocaine Actions. Journal of Medicinal Chemistry 2008, 51
(11)
, 3322-3325. https://doi.org/10.1021/jm7013666
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(9)
, 2795-2806. https://doi.org/10.1021/jm701270n
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(15)
, 5140-5149. https://doi.org/10.1021/ja077972s
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(5)
, 1482-1486. https://doi.org/10.1021/jm701357m
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(15)
, 4470-4476. https://doi.org/10.1021/jm0501634
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(5)
, 1766-1772. https://doi.org/10.1021/jm050766f
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(4)
, 1420-1432. https://doi.org/10.1021/jm050797a
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(8)
, 2767-2771. https://doi.org/10.1021/jm040185a
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(5)
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(2)
, 498-510. https://doi.org/10.1021/bi048680w
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(25)
, 6401-6409. https://doi.org/10.1021/jm0401311
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(25)
, 6137-6143. https://doi.org/10.1021/jm049544s
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(24)
, 5821-5824. https://doi.org/10.1021/jm040117o
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(21)
, 5101-5113. https://doi.org/10.1021/jm049796t
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(31)
, 10149-10156. https://doi.org/10.1021/bi049590u
- N. A. Larsen,, P. de Prada,, S.-X. Deng,, A. Mittal,, M. Braskett,, X. Zhu,, I. A. Wilson, and, D. W. Landry. Crystallographic and Biochemical Analysis of Cocaine-Degrading Antibody 15A10,. Biochemistry 2004, 43
(25)
, 8067-8076. https://doi.org/10.1021/bi049495l
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(7)
, 1676-1682. https://doi.org/10.1021/jm030430a
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(1)
, 133-142. https://doi.org/10.1021/jm030351z
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(21)
, 4377-4392. https://doi.org/10.1021/jm030085p
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(11)
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(10)
, 1997-2007. https://doi.org/10.1021/jm020596w
- F. Ivy Carroll. 2002 Medicinal Chemistry Division Award Address: Monoamine Transporters and Opioid Receptors. Targets for Addiction Therapy. Journal of Medicinal Chemistry 2003, 46
(10)
, 1775-1794. https://doi.org/10.1021/jm030092d
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(7)
, 1220-1228. https://doi.org/10.1021/jm020275k
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(19)
, 4119-4127. https://doi.org/10.1021/jm0102093
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(19)
, 4097-4109. https://doi.org/10.1021/jm010302r
- Bruce E. Blough,, Kathryn I. Keverline,, Zhe Nie,, Hernán Navarro,, Michael J. Kuhar, and, F. Ivy Carroll. Synthesis and Transporter Binding Properties of 3β-[4‘-(Phenylalkyl, -phenylalkenyl, and -phenylalkynl)phenyl]tropane-2β-carboxylic Acid Methyl Esters: Evidence of a Remote Phenyl Binding Domain on the Dopamine Transporter. Journal of Medicinal Chemistry 2002, 45
(18)
, 4029-4037. https://doi.org/10.1021/jm020098n
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(9)
, 1930-1941. https://doi.org/10.1021/jm0105373
- Paolo Benedetti,, Raimund Mannhold,, Gabriele Cruciani, and, Manuel Pastor. GBR Compounds and Mepyramines as Cocaine Abuse Therapeutics: Chemometric Studies on Selectivity Using Grid Independent Descriptors (GRIND). Journal of Medicinal Chemistry 2002, 45
(8)
, 1577-1584. https://doi.org/10.1021/jm011007+
- Lifen Xu,, Sari Izenwasser,, Jonathan L. Katz,, Theresa Kopajtic,, Cheryl Klein-Stevens,, Naiju Zhu,, Stacey A. Lomenzo,, Leyte Winfield, and, Mark L. Trudell. Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine Transporters. Journal of Medicinal Chemistry 2002, 45
(6)
, 1203-1210. https://doi.org/10.1021/jm010453u
- Aloke K. Dutta,, Matthew C. Davis,, Xiang-Shu Fei,, Patrick M. Beardsley,, Charles D. Cook, and, Maarten. E. A. Reith. Expansion of Structure−Activity Studies of Piperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) Compounds by Altering Substitutions in the N-Benzyl Moiety and Behavioral Pharmacology of Selected Molecules. Journal of Medicinal Chemistry 2002, 45
(3)
, 654-662. https://doi.org/10.1021/jm010316x
- Mu-Fa Zou,, Theresa Kopajtic,, Jonathan L. Katz,, Sara Wirtz,, Joseph B. Justice, Jr., and, Amy Hauck Newman. Novel Tropane-Based Irreversible Ligands for the Dopamine Transporter. Journal of Medicinal Chemistry 2001, 44
(25)
, 4453-4461. https://doi.org/10.1021/jm0101904
- Peter C. Meltzer,, Bing Wang,, Zhengming Chen,, Paul Blundell,, Muthusamy Jayaraman,, Mario D. Gonzalez,, Clifford George, and, Bertha K. Madras. Synthesis of 6- and 7- Hydroxy-8-azabicyclo[3.2.1]octanes and Their Binding Affinity for the Dopamine and Serotonin Transporters. Journal of Medicinal Chemistry 2001, 44
(16)
, 2619-2635. https://doi.org/10.1021/jm0101242
- Huw M. L. Davies,, Vernon Gilliatt,, Lisa A. Kuhn,, Elie Saikali,, Pingda Ren,, Philip S. Hammond,, Tammy Sexton, and, Steven R. Childers. Synthesis of 2β-Acyl-3β-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and Their Binding Affinities at Dopamine and Serotonin Transport Sites. Journal of Medicinal Chemistry 2001, 44
(10)
, 1509-1515. https://doi.org/10.1021/jm000363+
- Amir P. Tamiz,, Bidhan C. Bandyopadhyay,, Jianrong Zhang,, Judith L. Flippen-Anderson,, Mei Zhang,, Chen Z. Wang,, Kenneth M. Johnson,, Srihari Tella, and, Alan P. Kozikowski. Pharmacological and Behavioral Analysis of the Effects of Some Bivalent Ligand-Based Monoamine Reuptake Inhibitors. Journal of Medicinal Chemistry 2001, 44
(10)
, 1615-1622. https://doi.org/10.1021/jm000552s
- Amy Hauck Newman,, Michael J. Robarge,, Ileana M. Howard,, Sharine L. Wittkopp,, Clifford George,, Theresa Kopajtic,, Sari Izenwasser, and, Jonathan L. Katz. Structure−Activity Relationships at Monoamine Transporters and Muscarinic Receptors for N-Substituted-3α-(3‘-chloro-, 4‘-chloro-, and 4‘,4‘ ‘-dichloro-substituted-diphenyl)methoxytropanes. Journal of Medicinal Chemistry 2001, 44
(4)
, 633-640. https://doi.org/10.1021/jm000417f
- Mark Froimowitz,, Kuo-Ming Wu,, Adel Moussa,, Reem M. Haidar,, Jurjus Jurayj,, Clifford George, and, Eliot L. Gardner. Slow-Onset, Long-Duration 3-(3‘,4‘-Dichlorophenyl)-1-indanamine Monoamine Reuptake Blockers as Potential Medications To Treat Cocaine Abuse. Journal of Medicinal Chemistry 2000, 43
(26)
, 4981-4992. https://doi.org/10.1021/jm000201d
- Alexander Hoepping,, Kenneth M. Johnson,, Clifford George,, Judith Flippen-Anderson, and, Alan P. Kozikowski. Novel Conformationally Constrained Tropane Analogues by 6-endo-trig Radical Cyclization and Stille Coupling − Switch of Activity toward the Serotonin and/or Norepinephrine Transporter. Journal of Medicinal Chemistry 2000, 43
(10)
, 2064-2071. https://doi.org/10.1021/jm0001121
- Satendra Singh. Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists. Chemical Reviews 2000, 100
(3)
, 925-1024. https://doi.org/10.1021/cr9700538
- Dooti Kundu, Anlin Zhu, Eunae Kim, Suresh Paudel, Choon-Gon Jang, Yong Sup Lee, Kyeong-Man Kim. Potential Functional Role of Phenethylamine Derivatives in Inhibiting Dopamine Reuptake: Structure–Activity Relationship. Biomolecules & Therapeutics 2023, 31
(1)
, 108-115. https://doi.org/10.4062/biomolther.2022.047
- Chenguang Yu, He Huang, Chunquan Sheng, Wei Wang. Designing Efficient Cascade Reactions in Drug Discovery. 2022, 213-235. https://doi.org/10.1007/978-1-0716-1579-9_7
- A. V. Lavrova, N. M. Gretskaya, V. V. Bezuglov. Role of Oxidative Stress in the Etiology of Parkinson’s Disease: Advanced Therapeutic Products. Russian Journal of Bioorganic Chemistry 2021, 47
(5)
, 980-996. https://doi.org/10.1134/S1068162021050307
- Stephen H. Curry, Matthew Marler. Effects of ecgonine methyl ester on cognition in scopolamine-impaired and aged rats. Psychopharmacology 2020, 237
(5)
, 1331-1342. https://doi.org/10.1007/s00213-020-05460-9
- David F. Carreno, José Antonio Pérez-Escobar. Addiction in existential positive psychology (EPP, PP2.0): from a critique of the brain disease model towards a meaning-centered approach. Counselling Psychology Quarterly 2019, 32
(3-4)
, 415-435. https://doi.org/10.1080/09515070.2019.1604494
- F. Ivy Carroll, Thomas R. Kosten, Jeffrey J. Buda, Laurene Wang, Bradford B. Walters. A Double-Blind, Placebo-Controlled Trial Demonstrating the Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of RTI-336. Frontiers in Pharmacology 2018, 9 https://doi.org/10.3389/fphar.2018.00712
- . 4‐(Hetero)Arylpiperidines. 2018, 155-193. https://doi.org/10.1002/9781118686263.ch5
- Xue Qing Yang, Daniel Glizer, Andrew Vo, Ken N. Seergobin, Penny A. MacDonald. Pramipexole Increases Go Timeouts but Not No-go Errors in Healthy Volunteers. Frontiers in Human Neuroscience 2016, 10 https://doi.org/10.3389/fnhum.2016.00523
- Paul W. Czoty, William W. Stoops, Craig R. Rush, . Evaluation of the “Pipeline” for Development of Medications for Cocaine Use Disorder: A Review of Translational Preclinical, Human Laboratory, and Clinical Trial Research. Pharmacological Reviews 2016, 68
(3)
, 533-562. https://doi.org/10.1124/pr.115.011668
- Vivek Verma. Classic Studies on the Interaction of Cocaine and the Dopamine Transporter. Clinical Psychopharmacology and Neuroscience 2015, 13
(3)
, 227-238. https://doi.org/10.9758/cpn.2015.13.3.227
- Jeffrey L. Barr, Elena Deliu, G. Cristina Brailoiu, Pingwei Zhao, Guang Yan, Mary E. Abood, Ellen M. Unterwald, Eugen Brailoiu. Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor–inositol 1,4,5-trisphosphate–transient receptor potential canonical channel pathways. Cell Calcium 2015, 58
(2)
, 196-207. https://doi.org/10.1016/j.ceca.2015.05.001
- Tadeusz Aniszewski. Biology of alkaloids. 2015, 195-258. https://doi.org/10.1016/B978-0-444-59433-4.00003-1
- Stephen J. Kohut, Takato Hiranita, Soo-Kyung Hong, Aaron L. Ebbs, Valeria Tronci, Jennifer Green, Linda Garcés-Ramírez, Lauren E. Chun, Maddalena Mereu, Amy H. Newman, Jonathan L. Katz, Gianluigi Tanda. Preference for Distinct Functional Conformations of the Dopamine Transporter Alters the Relationship between Subjective Effects of Cocaine and Stimulation of Mesolimbic Dopamine. Biological Psychiatry 2014, 76
(10)
, 802-809. https://doi.org/10.1016/j.biopsych.2014.03.031
- Leonard L. Howell, S. Stevens Negus. Monoamine Transporter Inhibitors and Substrates as Treatments for Stimulant Abuse. 2014, 129-176. https://doi.org/10.1016/B978-0-12-420118-7.00004-4
- Paul W. Czoty, Susan E. Martelle, Robert W. Gould, Michael A. Nader. Effects of Chronic Methylphenidate on Cocaine Self-Administration under a Progressive-Ratio Schedule of Reinforcement in Rhesus Monkeys. Journal of Pharmacology and Experimental Therapeutics 2013, 345
(3)
, 374-382. https://doi.org/10.1124/jpet.113.204321
- Paul W. Czoty, Michael A. Nader. Effects of Dopamine D2/D3 Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys. Journal of Pharmacology and Experimental Therapeutics 2013, 344
(2)
, 329-338. https://doi.org/10.1124/jpet.112.201012
- Jonathan M. Slezak, Christopher A. Krebs, Karen G. Anderson. A within-subject analysis of d-amphetamine exposure on delay discounting in rats. Pharmacology Biochemistry and Behavior 2012, 102
(4)
, 502-506. https://doi.org/10.1016/j.pbb.2012.06.019
- Heather L. Kimmel, Jonathon A. Nye, Ronald Voll, Jiyoung Mun, Jeffrey Stehouwer, Mark M. Goodman, John R. Votaw, F.I. Carroll, Leonard L. Howell. Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys. Synapse 2012, 66
(6)
, 501-508. https://doi.org/10.1002/syn.21536
- Lokman Torun, Bertha K. Madras, Peter C. Meltzer. Synthesis and structure–activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters. Bioorganic & Medicinal Chemistry 2012, 20
(8)
, 2762-2772. https://doi.org/10.1016/j.bmc.2012.01.053
- Craig R Rush, William W Stoops. Agonist replacement therapy for cocaine dependence: a translational review. Future Medicinal Chemistry 2012, 4
(2)
, 245-265. https://doi.org/10.4155/fmc.11.184
- Shaine A. Cararas, Sari Izenwasser, Dean Wade, Amy Housman, Abha Verma, Stacey A. Lomenzo, Mark L. Trudell. Further structure–activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. Bioorganic & Medicinal Chemistry 2011, 19
(24)
, 7551-7558. https://doi.org/10.1016/j.bmc.2011.10.028
- Nidhi Kaushal, Matthew J. Robson, Harsha Vinnakota, Sanju Narayanan, Bonnie A. Avery, Christopher R. McCurdy, Rae R. Matsumoto. Synthesis and Pharmacological Evaluation of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a Cocaine Antagonist, in Rodents. The AAPS Journal 2011, 13
(3)
, 336-346. https://doi.org/10.1208/s12248-011-9274-9
- B L Blaylock, R W Gould, A Banala, P Grundt, R R Luedtke, A H Newman, M A Nader. Influence of Cocaine History on the Behavioral Effects of Dopamine D3 Receptor-Selective Compounds in Monkeys. Neuropsychopharmacology 2011, 36
(5)
, 1104-1113. https://doi.org/10.1038/npp.2010.248
- Paul W Czoty, Robert W Gould, Jennifer L Martelle, Michael A Nader. Prolonged Attenuation of the Reinforcing Strength of Cocaine by Chronic d-Amphetamine in Rhesus Monkeys. Neuropsychopharmacology 2011, 36
(2)
, 539-547. https://doi.org/10.1038/npp.2010.185
- Theresa A. Kopajtic, Yi Liu, Christopher K. Surratt, David M. Donovan, Amy H. Newman, Jonathan L. Katz. Dopamine Transporter-Dependent and -Independent Striatal Binding of the Benztropine Analog JHW 007, a Cocaine Antagonist with Low Abuse Liability. Journal of Pharmacology and Experimental Therapeutics 2010, 335
(3)
, 703-714. https://doi.org/10.1124/jpet.110.171629
- Paul W. Czoty, Jennifer L. Martelle, F. Ivy Carroll, Michael A. Nader. Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates. Pharmacology Biochemistry and Behavior 2010, 96
(3)
, 274-278. https://doi.org/10.1016/j.pbb.2010.05.017
- Paul W. Czoty, Jennifer L. Martelle, Michael A. Nader. Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology 2010, 209
(4)
, 375-382. https://doi.org/10.1007/s00213-010-1807-x
- Vitaly Palamarchouk, Gennady Smagin, Nicholas E. Goeders. Self-administered and passive cocaine infusions produce different effects on corticosterone concentrations in the medial prefrontal cortex (MPC) of rats. Pharmacology Biochemistry and Behavior 2009, 94
(1)
, 163-168. https://doi.org/10.1016/j.pbb.2009.08.003
- Emily M. Jutkiewicz, Michelle G. Baladi, Ziva D. Cooper, Diwahar Narasimhan, Roger K. Sunahara, James H. Woods. A Bacterial Cocaine Esterase Protects Against Cocaine-Induced Epileptogenic Activity and Lethality. Annals of Emergency Medicine 2009, 54
(3)
, 409-420. https://doi.org/10.1016/j.annemergmed.2008.09.023
- Gianluigi Tanda, Amy Hauck Newman, Aaron L. Ebbs, Valeria Tronci, Jennifer L. Green, Ronald J. Tallarida, Jonathan L. Katz. Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity. Journal of Pharmacology and Experimental Therapeutics 2009, 330
(3)
, 802-809. https://doi.org/10.1124/jpet.109.154302
- Prashant S. Kharkar, Angela M. Batman, Juan Zhen, Patrick M. Beardsley, Maarten E. A. Reith, Aloke K. Dutta. Synthesis and Biological Characterization of (3
R
,4
R
)‐4‐(2‐(Benzhydryloxy)ethyl)‐1‐((
R
)‐2‐hydroxy‐2‐phenylethyl)‐piperidin‐3‐ol and Its Stereoisomers for Activity toward Monoamine Transporters. ChemMedChem 2009, 4
(7)
, 1075-1085. https://doi.org/10.1002/cmdc.200900085
- Chunyang Jin, Hernán A. Navarro, F. Ivy Carroll. Synthesis and structure–activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters. Bioorganic & Medicinal Chemistry 2009, 17
(14)
, 5126-5132. https://doi.org/10.1016/j.bmc.2009.05.052
- Gianluigi Tanda, Amy H. Newman, Jonathan L. Katz. Discovery of Drugs to Treat Cocaine Dependence: Behavioral and Neurochemical Effects of Atypical Dopamine Transport Inhibitors. 2009, 253-289. https://doi.org/10.1016/S1054-3589(08)57007-4
- Jeffrey S. Stehouwer, Mark M. Goodman. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET Clinics 2009, 4
(1)
, 101-128. https://doi.org/10.1016/j.cpet.2009.05.006
- Ahmed A. Othman, Amy H. Newman, Natalie D. Eddington. The novel N‐substituted benztropine analog GA2‐50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse. Journal of Pharmaceutical Sciences 2008, 97
(12)
, 5453-5470. https://doi.org/10.1002/jps.21389
- Shariq A. Syed, Amy H. Newman, Ahmed A. Othman, Natalie D. Eddington. Population Pharmacokinetics, Brain Distribution, and Pharmacodynamics of 2nd Generation Dopamine Transporter Selective Benztropine Analogs Developed as Potential Substitute Therapeutics for Treatment of Cocaine Abuse. Journal of Pharmaceutical Sciences 2008, 97
(5)
, 1993-2007. https://doi.org/10.1002/jps.21123
- F. Ivy Carroll, James L. Howard, Leonard L. Howell, Barbara S. Fox, Michael J. Kuhar. Development of the Dopamine Transporter Selective RTI-336 as a Pharmacotherapy for Cocaine Abuse. 2008, 179-191. https://doi.org/10.1007/978-0-387-76678-2_12
- Thomas E. Prisinzano, Kevin Tidgewell, Wayne W. Harding. κ Opioids as Potential Treatments for Stimulant Dependence. 2008, 231-245. https://doi.org/10.1007/978-0-387-76678-2_15
- Gianluigi Tanda. Modulation of the endocannabinoid system: Therapeutic potential against cocaine dependence. Pharmacological Research 2007, 56
(5)
, 406-417. https://doi.org/10.1016/j.phrs.2007.09.001
- Helena S. Christensen, Søren V. Boye, Jacob Thinggaard, Steffen Sinning, Ove Wiborg, Birgit Schiøtt, Mikael Bols. QSAR studies and pharmacophore identification for arylsubstituted cycloalkenecarboxylic acid methyl esters with affinity for the human dopamine transporter. Bioorganic & Medicinal Chemistry 2007, 15
(15)
, 5262-5274. https://doi.org/10.1016/j.bmc.2007.05.015
- A.N. Carey, K. Borozny, J.V. Aldrich, J.P. McLaughlin. Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. European Journal of Pharmacology 2007, 569
(1-2)
, 84-89. https://doi.org/10.1016/j.ejphar.2007.05.007
- Vishakantha Murthy, Huw M.L. Davies, Simon J. Hedley, Steven R. Childers. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical Pharmacology 2007, 74
(2)
, 336-344. https://doi.org/10.1016/j.bcp.2007.04.019
- Mikkel Due Petersen, Søren Valdgård Boye, Erik Holm Nielsen, Jeanette Willumsen, Steffen Sinning, Ove Wiborg, Mikael Bols. Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters. Bioorganic & Medicinal Chemistry 2007, 15
(12)
, 4159-4174. https://doi.org/10.1016/j.bmc.2007.03.069
- Antonio Preti. REVIEW: New developments in the pharmacotherapy of cocaine abuse. Addiction Biology 2007, 12
(2)
, 133-151. https://doi.org/10.1111/j.1369-1600.2007.00061.x
- Jennifer L. Martelle, Renee Claytor, Jason T. Ross, Beth A. Reboussin, Amy Hauck Newman, Michael A. Nader. Effects of Two Novel D
3
-Selective Compounds, NGB 2904 [
N
-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9
H
-fluorene-2-carboxamide] and CJB 090 [
N
-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys. Journal of Pharmacology and Experimental Therapeutics 2007, 321
(2)
, 573-582. https://doi.org/10.1124/jpet.106.113571
- S. S. Negus, N. K. Mello, B. E. Blough, M. H. Baumann, R. B. Rothman. Monoamine Releasers with Varying Selectivity for Dopamine/Norepinephrine versus Serotonin Release as Candidate “Agonist” Medications for Cocaine Dependence: Studies in Assays of Cocaine Discrimination and Cocaine Self-Administration in Rhesus Monkeys. Journal of Pharmacology and Experimental Therapeutics 2007, 320
(2)
, 627-636. https://doi.org/10.1124/jpet.106.107383
- . References. 2007, 237-286. https://doi.org/10.1016/B978-044452736-3/50009-X
- Heather L. Kimmel, Joann A. O'Connor, F. Ivy Carroll, Leonard L. Howell. Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. Pharmacology Biochemistry and Behavior 2007, 86
(1)
, 45-54. https://doi.org/10.1016/j.pbb.2006.12.006
- Ahmed A. Othman, Shariq A. Syed, Amy H. Newman, Natalie D. Eddington. Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse. Journal of Pharmacology and Experimental Therapeutics 2007, 320
(1)
, 344-353. https://doi.org/10.1124/jpet.106.111245
- David M. Penetar, Alison R. Looby, Zhaohui Su, Leslie H. Lundahl, Monika Erös-Sarnyai, Jane F. McNeil, Scott E. Lukas. Benztropine pretreatment does not affect responses to acute cocaine administration in human volunteers. Human Psychopharmacology: Clinical and Experimental 2006, 21
(8)
, 549-559. https://doi.org/10.1002/hup.810
- Suhong Zhang, Sari Izenwasser, Dean Wade, Liang Xu, Mark L. Trudell. Synthesis of dopamine transporter selective 3-diarylmethoxymethyl-8-arylalkyl-8-azabicyclo[3.2.1]octane derivatives. Bioorganic & Medicinal Chemistry 2006, 14
(23)
, 7943-7952. https://doi.org/10.1016/j.bmc.2006.07.051
- Paul W. Czoty, Jennifer L. Martelle, Michael A. Nader. Influence of abstinence and conditions of cocaine access on the reinforcing strength of cocaine in nonhuman primates. Drug and Alcohol Dependence 2006, 85
(3)
, 213-220. https://doi.org/10.1016/j.drugalcdep.2006.04.009
- Ziva D. Cooper, Diwahar Narasimhan, Roger K. Sunahara, Pawel Mierzejewski, Emily M. Jutkiewicz, Nicholas A. Larsen, Ian A. Wilson, Donald W. Landry, James H. Woods. Rapid and Robust Protection against Cocaine-Induced Lethality in Rats by the Bacterial Cocaine Esterase. Molecular Pharmacology 2006, 70
(6)
, 1885-1891. https://doi.org/10.1124/mol.106.025999
- Gail Pereira Do Carmo, Nancy K. Mello, Kenner C. Rice, John E. Folk, S. Stevens Negus. Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. European Journal of Pharmacology 2006, 547
(1-3)
, 92-100. https://doi.org/10.1016/j.ejphar.2006.06.075
- Ravid Doron, Lilach Fridman, Iris Gispan-Herman, Rachel Maayan, Abraham Weizman, Gal Yadid. DHEA, a Neurosteroid, Decreases Cocaine Self-Administration and Reinstatement of Cocaine-Seeking Behavior in Rats. Neuropsychopharmacology 2006, 31
(10)
, 2231-2236. https://doi.org/10.1038/sj.npp.1301013