A Two-Directional Synthesis of (±)-Perhydrohistrionicotoxin
Abstract

An entirely two-directional synthesis of (±)-perhydrohistrionicotoxin is presented, utilizing a tandem oxime formation/Michael addition/[3 + 2] cycloaddition as the key step. This approach also constitutes formal syntheses of (±)-histrionicotoxin and (±)-histrionicotoxin 235A.
*
Phone: +44 (0) 1603 593890. Fax: +44 (0) 1603 592003.
†
School of Chemical Sciences and Pharmacy, University of East Anglia.
‡
GlaxoSmithKline.
§
X-ray Crystallographic Unit, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK.
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