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Ultrabright BODIPY-Tagged Polystyrene Nanoparticles: Study of Concentration Effect on Photophysical Properties
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    Ultrabright BODIPY-Tagged Polystyrene Nanoparticles: Study of Concentration Effect on Photophysical Properties
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    PPSM, ENS Cachan, CNRS, 61 av Président Wilson, F-94230 Cachan, France
    Sorbonne Universités, UPMC Univ Paris 06, UMR 8232, Institut Parisien de Chimie Moléculaire (IPCM), Equipe Chimie des Polymères, F-75005, Paris, France
    § CNRS, UMR 8232, Institut Parisien de Chimie Moléculaire (IPCM), Equipe Chimie des Polymères, F-75005, Paris, France
    Université de Lyon, Université Lyon 1, CPE Lyon, CNRS UMR 5265, C2P2, Team LCPP Bat 308F, 43 Bd du 11 novembre 1918, 69616 Villeurbanne, France
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    The Journal of Physical Chemistry C

    Cite this: J. Phys. Chem. C 2014, 118, 25, 13945–13952
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    https://doi.org/10.1021/jp502790w
    Published June 4, 2014
    Copyright © 2014 American Chemical Society

    Abstract

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    Fluorescent nanomaterials are invaluable tools for bioimaging. Polymeric nanoparticles labeled with organic dyes are very promising for this purpose. It is thus very important to fully understand their photophysical properties. New fluorescent core–shell nanoparticles have been prepared. The outer part is a poly(ethylene glycol)-block-poly(acrylic acid) copolymer, and the core is a copolymer of styrene and methacrylic BODIPY fluorophore. The hydrophilic and hydrophobic parts are covalently linked, ensuring both stability and biocompatibility. We prepared nanoparticles with increasing amounts of BODIPY, from 500 to 5000 fluorophores per particles. Increasing the concentration of BODIPY lowers both the fluorescence quantum yield and the lifetime. However, the brightness of the individual particles increases up to 8 × 107. To understand the loss of fluorescence efficiency, fluorescence decays have been recorded and fitted with a mathematical model using a stretched exponential function. This result gives an insight into the fluorophore arrangement within the hydrophobic core.

    Copyright © 2014 American Chemical Society

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    Molecular structure of BDPMA, synthetic details and characteristics of the nanoparticles, and fluorescence decays of monomer and nanoparticles in water and toluene. This material is available free of charge via the Internet at http://pubs.acs.org.

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    This article is cited by 19 publications.

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    The Journal of Physical Chemistry C

    Cite this: J. Phys. Chem. C 2014, 118, 25, 13945–13952
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jp502790w
    Published June 4, 2014
    Copyright © 2014 American Chemical Society

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