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Oxidation-Sensitive Polymeric Nanoparticles

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Institute for Biomedical Engineering and Department of Materials, Swiss Federal Institute of Technology (ETH) and University of Zurich, Moussonstrasse 18, CH-8044 Zurich, Switzerland, and School of Pharmacy and Centre for Molecular Materials, University of Manchester, Oxford Road, M13 9PL Manchester, United Kingdom
Cite this: Langmuir 2005, 21, 1, 411–417
Publication Date (Web):December 2, 2004
https://doi.org/10.1021/la0478043
Copyright © 2005 American Chemical Society
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    Abstract

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    We have recently demonstrated the possible use of organic polysulfides for the design of oxidation-sensitive colloidal carriers in the form of polymeric vesicles, which are particularly suitable for the encapsulation of hydrosoluble drugs. In the present research we extend our efforts to carriers specifically suitable for hydrophobic molecules. Exploiting the living emulsion polymerization of episulfides, we have produced new cross-linked polysulfide nanoparticles. Here we demonstrate how this process allows the production of stable nanoparticles with a good control over their size and functionality. The nanoparticles showed negligible cytotoxicity on a fibroblast model; furthermore, they exhibited sensitivity to oxidative conditions, which first produce swelling and then solubilize the material.

    †

     Swiss Federal Institute of Technology (ETH) and University of Zurich.

    *

     To whom correspondence should be addressed. Tel.:  +44 161 275 24 80. Fax.:  +44 161 275 23 96. E-mail:  [email protected].

    ‡

     University of Manchester.

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