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    Research Article

    Generation of Polymerosomes from Double-Emulsions
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    Department of Physics and Division of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts 02138, and Rhodia-CNRS, Laboratory of the Future LOF, 33600 Pessac, France
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    Langmuir

    Cite this: Langmuir 2005, 21, 20, 9183–9186
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    https://doi.org/10.1021/la050797d
    Published August 23, 2005
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    Abstract

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    Diblock copolymers are known to spontaneously organize into polymer vesicles. Typically, this is achieved through the techniques of film rehydration or electroformation. We present a new method for generating polymer vesicles from double emulsions. We generate precision water-in-oil-in-water double emulsions from the breakup of concentric fluid streams; the hydrophobic fluid is a volatile mixture of organic solvent that contains dissolved diblock copolymers. We collect the double emulsions and slowly evaporate the organic solvent, which ultimately directs the self-assembly of the dissolved diblock copolymers into vesicular structures. Independent control over all three fluid streams enables precision assembly of polymer vesicles and provides for highly efficient encapsulation of active ingredients within the polymerosomes. We also use double emulsions with several internal drops to form new polymerosome structures.

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    §

     These authors contributed equally to this work.

    #

     Department of Physics and Division of Engineering and Applied Science, Harvard University.

    ‡

     Current address: LPMDI − UMR 8108 CNRS, Université de Marne-la-Vallée, France.

    †

     Rhodia-CNRS, Laboratory of the Future LOF.

    *

     To whom correspondence should be addressed. E-mail:  weitz@ deas.harvard.edu.

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    Cite this: Langmuir 2005, 21, 20, 9183–9186
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    https://doi.org/10.1021/la050797d
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