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Generation of Polymerosomes from Double-Emulsions
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    Generation of Polymerosomes from Double-Emulsions
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    Department of Physics and Division of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts 02138, and Rhodia-CNRS, Laboratory of the Future LOF, 33600 Pessac, France
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    Langmuir

    Cite this: Langmuir 2005, 21, 20, 9183–9186
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    https://doi.org/10.1021/la050797d
    Published August 23, 2005
    Copyright © 2005 American Chemical Society

    Abstract

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    Diblock copolymers are known to spontaneously organize into polymer vesicles. Typically, this is achieved through the techniques of film rehydration or electroformation. We present a new method for generating polymer vesicles from double emulsions. We generate precision water-in-oil-in-water double emulsions from the breakup of concentric fluid streams; the hydrophobic fluid is a volatile mixture of organic solvent that contains dissolved diblock copolymers. We collect the double emulsions and slowly evaporate the organic solvent, which ultimately directs the self-assembly of the dissolved diblock copolymers into vesicular structures. Independent control over all three fluid streams enables precision assembly of polymer vesicles and provides for highly efficient encapsulation of active ingredients within the polymerosomes. We also use double emulsions with several internal drops to form new polymerosome structures.

    Copyright © 2005 American Chemical Society

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    §

     These authors contributed equally to this work.

    #

     Department of Physics and Division of Engineering and Applied Science, Harvard University.

     Current address: LPMDI − UMR 8108 CNRS, Université de Marne-la-Vallée, France.

     Rhodia-CNRS, Laboratory of the Future LOF.

    *

     To whom correspondence should be addressed. E-mail:  weitz@ deas.harvard.edu.

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    11. Regina Bleul, Raphael Thiermann, and Michael Maskos . Techniques To Control Polymersome Size. Macromolecules 2015, 48 (20) , 7396-7409. https://doi.org/10.1021/acs.macromol.5b01500
    12. Jae Man Shin, Minsoo P. Kim, Hyunseung Yang, Kang Hee Ku, Se Gyu Jang, Kyung Ho Youm, Gi-Ra Yi, and Bumjoon J. Kim . Monodipserse Nanostructured Spheres of Block Copolymers and Nanoparticles via Cross-Flow Membrane Emulsification. Chemistry of Materials 2015, 27 (18) , 6314-6321. https://doi.org/10.1021/acs.chemmater.5b02020
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    14. Ingmar Polenz, Sujit S. Datta, and David A. Weitz . Controlling the Morphology of Polyurea Microcapsules Using Microfluidics. Langmuir 2014, 30 (44) , 13405-13410. https://doi.org/10.1021/la503234z
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    16. Douglas L. Gettel, Jeremy Sanborn, Mira A. Patel, Hans-Peter de Hoog, Bo Liedberg, Madhavan Nallani, and Atul N. Parikh . Mixing, Diffusion, and Percolation in Binary Supported Membranes Containing Mixtures of Lipids and Amphiphilic Block Copolymers. Journal of the American Chemical Society 2014, 136 (29) , 10186-10189. https://doi.org/10.1021/ja5037308
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    23. Smita Kashyap and M. Jayakannan . Amphiphilic Diblocks Sorting into Multivesicular Bodies and Their Fluorophore Encapsulation Capabilities. The Journal of Physical Chemistry B 2012, 116 (32) , 9820-9831. https://doi.org/10.1021/jp304121d
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    43. Shin-Hyun Kim, Seog-Jin Jeon and Seung-Man Yang. Optofluidic Encapsulation of Crystalline Colloidal Arrays into Spherical Membrane. Journal of the American Chemical Society 2008, 130 (18) , 6040-6046. https://doi.org/10.1021/ja800844w
    44. Shinji Sugiura,, Takashi Kuroiwa,, Tetsuro Kagota,, Mitsutoshi Nakajima,, Seigo Sato,, Sukekuni Mukataka,, Peter Walde, and, Sosaku Ichikawa. Novel Method for Obtaining Homogeneous Giant Vesicles from a Monodisperse Water-in-Oil Emulsion Prepared with a Microfluidic Device. Langmuir 2008, 24 (9) , 4581-4588. https://doi.org/10.1021/la703509r
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    54. Chantal Joseph Abou-Fayssal, Rinaldo Poli, Karine Philippot, Anders Riisager, Eric Manoury. Polymeric nanoreactors for catalytic applications. Comptes Rendus. Chimie 2024, 27 (S1) , 45-67. https://doi.org/10.5802/crchim.301
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    56. Laura Velasco-Garcia, Carla Casadevall. Bioinspired photocatalytic systems towards compartmentalized artificial photosynthesis. Communications Chemistry 2023, 6 (1) https://doi.org/10.1038/s42004-023-01069-z
    57. Jean-Paul Douliez, Anais Arlaut, Laure Beven, Anne-Laure Fameau, Arnaud Saint-Jalmes. One step generation of single-core double emulsions from polymer-osmose-induced aqueous phase separation in polar oil droplets. Soft Matter 2023, 19 (39) , 7562-7569. https://doi.org/10.1039/D3SM00970J
    58. POONAM JOSHI, NIDHI NAINWAL, SRISHTI MORRIS, VIKAS JAKHMOLA. A REVIEW ON RECENT ADVANCES ON STIMULI BASED SMART NANOMATERIALS FOR DRUG DELIVERY AND BIOMEDICAL APPLICATION. International Journal of Applied Pharmaceutics 2023, , 48-59. https://doi.org/10.22159/ijap.2023v15i5.48186
    59. Marina Koroleva. Multicompartment colloid systems with lipid and polymer membranes for biomedical applications. Physical Chemistry Chemical Physics 2023, 25 (33) , 21836-21859. https://doi.org/10.1039/D3CP01984E
    60. Cagri Turan, Ipek Terzioglu, Dilara Gundogdu, Irem Erel-Goktepe. Synthesis of poly(2-isopropyl-2-oxazoline)-b-poly(2-phenyl-2-oxazoline)-b-poly(2-isopropyl-2-oxazoline) and its self-assembly into polymersomes: Temperature-dependent aqueous solution behavior. Materials Today Communications 2023, 35 , 106094. https://doi.org/10.1016/j.mtcomm.2023.106094
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    62. Yogita Lugani, Venkata Ramana Vemuluri, Balwinder Singh Sooch. Nanotechnology: Emerging Opportunities and Regulatory Aspects in Water Treatment. 2023, 173-209. https://doi.org/10.1007/978-3-031-24416-2_6
    63. M. Senthil Kumar, L.V. Vigneshwaran. Novel biomimetic polymersomes as polymer therapeutics for drug delivery. 2023, 437-463. https://doi.org/10.1016/B978-0-323-91248-8.00018-0
    64. Zhiliang Gao, Xiaomiao Cui, Jiwei Cui. Multicompartment polymer capsules. Supramolecular Materials 2022, 1 , 100015. https://doi.org/10.1016/j.supmat.2022.100015
    65. Karim Osouli-Bostanabad, Sara Puliga, Dolores R. Serrano, Andrea Bucchi, Gavin Halbert, Aikaterini Lalatsa. Microfluidic Manufacture of Lipid-Based Nanomedicines. Pharmaceutics 2022, 14 (9) , 1940. https://doi.org/10.3390/pharmaceutics14091940
    66. Hui Chen, Min‐Hui Li. AIE Fluorescent Polymersomes. 2022, 311-339. https://doi.org/10.1002/9781119643098.ch32
    67. Junwei Wang, Simon Hahn, Esther Amstad, Nicolas Vogel. Tailored Double Emulsions Made Simple. Advanced Materials 2022, 34 (5) https://doi.org/10.1002/adma.202107338
    68. Martin Fauquignon, Elise Courtecuisse, Romane Josselin, Angela Mutschler, Annie Brûlet, Marc Schmutz, Jean-François Le Meins. Large hybrid Polymer/Lipid Unilamellar vesicle (LHUV) at the nanoscale: An insight into the lipid distribution in the membrane and permeability control. Journal of Colloid and Interface Science 2021, 604 , 575-583. https://doi.org/10.1016/j.jcis.2021.06.172
    69. Sehrish Iftikhar, Aurélie Vigne, Julia Elisa Sepulveda-Diaz. Droplet-based microfluidics platform for antifungal analysis against filamentous fungi. Scientific Reports 2021, 11 (1) https://doi.org/10.1038/s41598-021-02350-8
    70. Bineet Sharma, Hossein Moghimianavval, Sung-Won Hwang, Allen P. Liu. Synthetic Cell as a Platform for Understanding Membrane-Membrane Interactions. Membranes 2021, 11 (12) , 912. https://doi.org/10.3390/membranes11120912
    71. Liliya Kotliarevski, Karthik Ananth Mani, Reut Amar Feldbaum, Noga Yaakov, Eduard Belausov, Einat Zelinger, Dana Ment, Guy Mechrez. Single-Conidium Encapsulation in Oil-in-Water Pickering Emulsions at High Encapsulation Yield. Frontiers in Chemistry 2021, 9 https://doi.org/10.3389/fchem.2021.726874
    72. Esra Ilhan-Ayisigi, Burcu Yaldiz, Gizem Bor, Anan Yaghmur, Ozlem Yesil-Celiktas. Advances in microfluidic synthesis and coupling with synchrotron SAXS for continuous production and real-time structural characterization of nano-self-assemblies. Colloids and Surfaces B: Biointerfaces 2021, 201 , 111633. https://doi.org/10.1016/j.colsurfb.2021.111633
    73. Hanjin Seo, Hyomin Lee. Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors. Biomicrofluidics 2021, 15 (2) https://doi.org/10.1063/5.0048441
    74. Vandana Singh, Archana Tiwari. Wastewater remediation through microbe-based nanoparticles. 2021, 237-248. https://doi.org/10.1016/B978-0-12-822503-5.00024-2
    75. Shanlong Li, Chunyang Yu, Yongfeng Zhou. Computational design of Janus polymersomes with controllable fission from double emulsions. Physical Chemistry Chemical Physics 2020, 22 (43) , 24934-24942. https://doi.org/10.1039/D0CP04561F
    76. Abhishek Kumar Sharma, Parteek Prasher, Alaa A. Aljabali, Vijay Mishra, Himanshu Gandhi, Sunil Kumar, Srinivas Mutalik, Dinesh Kumar Chellappan, Murtaza M. Tambuwala, Kamal Dua, Deepak N. Kapoor. Emerging era of “somes”: polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy. Drug Delivery and Translational Research 2020, 10 (5) , 1171-1190. https://doi.org/10.1007/s13346-020-00789-2
    77. G. Pontrelli, E. J. Carr, A. Tiribocchi, S. Succi. Modeling drug delivery from multiple emulsions. Physical Review E 2020, 102 (2) https://doi.org/10.1103/PhysRevE.102.023114
    78. Yuan Tian, Xinyu Mao, Rui Sun, Ming Zhang, Qiang Xia. Enhanced oral bioavailability of oligomeric proanthocyanidins by a self‐double‐emulsifying drug delivery system. Food Science & Nutrition 2020, 8 (7) , 3814-3825. https://doi.org/10.1002/fsn3.1673
    79. Elena C. dos Santos, Alessandro Angelini, Dimitri Hürlimann, Wolfgang Meier, Cornelia G. Palivan. Giant Polymer Compartments for Confined Reactions. Chemistry 2020, 2 (2) , 470-489. https://doi.org/10.3390/chemistry2020028
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    81. Dawei Pan, Qiang Chen, Shufan Chen, Bo Li. Experimental study on millimeter-scale W1/O/W2 compound droplets formation in a co-flowing device with two-step structure. Chemical Engineering Science 2020, 216 , 115493. https://doi.org/10.1016/j.ces.2020.115493
    82. Dawei Pan, Qiang Chen, Yinjuan Zhang, Bo Li. Investigation on millimeter-scale W1/O/W2 compound droplets generation in a co-flowing device with one-step structure. Journal of Industrial and Engineering Chemistry 2020, 84 , 366-374. https://doi.org/10.1016/j.jiec.2020.01.020
    83. Zehua Liu, Flavia Fontana, Andre Python, Jouni T. Hirvonen, Hélder A. Santos. Microfluidics for Production of Particles: Mechanism, Methodology, and Applications. Small 2020, 16 (9) https://doi.org/10.1002/smll.201904673
    84. Nina Filipczak, Jiayi Pan, Satya Siva Kishan Yalamarty, Vladimir P. Torchilin. Recent advancements in liposome technology. Advanced Drug Delivery Reviews 2020, 156 , 4-22. https://doi.org/10.1016/j.addr.2020.06.022
    85. Fitsum Feleke Sahle, Tao L. Lowe. Design strategies for programmable oligonucleotide nanotherapeutics. Drug Discovery Today 2020, 25 (1) , 73-88. https://doi.org/10.1016/j.drudis.2019.09.006
    86. Meifang Liu, Yueqing Zheng, Yiyang Liu, Zhanwen Zhang, Yuguang Wang, Jing Li, Qiang Chen, Jie Li, Yawen Huang, Qiang Yin. Effects of poly(vinyl alcohol) and poly(acrylic acid) on interfacial properties and stability of compound droplets. International Journal of Hydrogen Energy 2020, 45 (4) , 2925-2935. https://doi.org/10.1016/j.ijhydene.2019.11.129
    87. Yulan Chen, Zhenzhen Lu, Qingxia Liu. Janus membrane emulsification for facile preparation of hollow microspheres. Journal of Membrane Science 2019, 592 , 117384. https://doi.org/10.1016/j.memsci.2019.117384
    88. Babak Vajdi Hokmabad, Kyle A. Baldwin, Carsten Krüger, Christian Bahr, Corinna C. Maass. Topological Stabilization and Dynamics of Self-Propelling Nematic Shells. Physical Review Letters 2019, 123 (17) https://doi.org/10.1103/PhysRevLett.123.178003
    89. Sujit Kumar Ghosh, Alexander Böker. Self‐Assembly of Nanoparticles in 2D and 3D: Recent Advances and Future Trends. Macromolecular Chemistry and Physics 2019, 220 (17) https://doi.org/10.1002/macp.201900196
    90. Sagardip Majumder, Nadab Wubshet, Allen P Liu. Encapsulation of complex solutions using droplet microfluidics towards the synthesis of artificial cells. Journal of Micromechanics and Microengineering 2019, 29 (8) , 083001. https://doi.org/10.1088/1361-6439/ab2377
    91. Xiaojun Wang, Jiayi Zhu, Ting Shao, Xuan Luo, Lin Zhang. Production of Highly Monodisperse Millimeter‐Sized Double‐Emulsion Droplets in a Coaxial Capillary Device. Chemical Engineering & Technology 2019, 42 (6) , 1330-1340. https://doi.org/10.1002/ceat.201800040
    92. Pashiini Supramaniam, Oscar Ces, Ali Salehi-Reyhani. Microfluidics for Artificial Life: Techniques for Bottom-Up Synthetic Biology. Micromachines 2019, 10 (5) , 299. https://doi.org/10.3390/mi10050299
    93. Shukai Ding, Christophe A. Serra, Thierry F. Vandamme, Wei Yu, Nicolas Anton. Double emulsions prepared by two–step emulsification: History, state-of-the-art and perspective. Journal of Controlled Release 2019, 295 , 31-49. https://doi.org/10.1016/j.jconrel.2018.12.037
    94. Fatih Inci. Lipid Bilayers and Liposomes on Microfluidics Realm: Techniques and Applications. 2019, 213-223. https://doi.org/10.1007/978-3-030-11596-8_9
    95. Mona Alibolandi, Mahsa Shahriari, Mohammad Ramezani. Smart Polymersomes as Intelligent Nanomedicines in Cancer Treatment. 2019, 343-371. https://doi.org/10.1016/B978-0-12-816963-6.00016-9
    96. Saebom Ko, Chun Huh. Use of nanoparticles for oil production applications. Journal of Petroleum Science and Engineering 2019, 172 , 97-114. https://doi.org/10.1016/j.petrol.2018.09.051
    97. Meifang Liu, Yawen Huang, Sufen Chen, Dawei Pan, Miao Chen, Qiaomei Chu, Yiyang Liu, Qiang Yin, Zhanwen Zhang. Progress and challenges in the fabrication of DPS shells for ICF. Matter and Radiation at Extremes 2019, 4 (1) https://doi.org/10.1063/1.5081945
    98. Guoshu Wang, Kathrin Castiglione. Light-Driven Biocatalysis in Liposomes and Polymersomes: Where Are We Now?. Catalysts 2019, 9 (1) , 12. https://doi.org/10.3390/catal9010012
    99. Kyoung-Ku Kang, Byungjin Lee, Chang-Soo Lee. Microfluidic approaches for the design of functional materials. Microelectronic Engineering 2018, 199 , 1-15. https://doi.org/10.1016/j.mee.2018.07.007
    100. Xiaojun Wang, Jiayi Zhu, Ting Shao, Shufan Chen, Xuan Luo, Lin Zhang. Microfluidic‐assisted controllable formation of millimeter‐scale poly(divinylbenzene) foam shells. Polymer Engineering & Science 2018, 58 (7) , 1184-1192. https://doi.org/10.1002/pen.24680
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    Cite this: Langmuir 2005, 21, 20, 9183–9186
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    https://doi.org/10.1021/la050797d
    Published August 23, 2005
    Copyright © 2005 American Chemical Society

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