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Carboxybetaine Methacrylate Polymers Offer Robust, Long-Term Protection against Cell Adhesion

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    Carboxybetaine Methacrylate Polymers Offer Robust, Long-Term Protection against Cell Adhesion
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    † ‡ †Department of Chemical and Biological Engineering and ‡Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States
    § Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, United States
    E-mail: [email protected] (K.K.-G.); [email protected] (B.A.G.).
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    Langmuir

    Cite this: Langmuir 2011, 27, 17, 10800–10804
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    https://doi.org/10.1021/la201066y
    Published June 28, 2011
    Copyright © 2011 American Chemical Society
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    Abstract

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    Films of poly(carboxybetaine methacrylate), poly(CBMA), grafted onto microetched gold slides are effective in preventing nonspecific adhesion of cells of different types. The degree of adhesion resistance is comparable to that achieved with the self-assembled monolayers, SAMs, of oligo(ethylene glycol) alkanethiolates. In sharp contrast to the SAMs, however, substrates protected with poly(CBMA) can be stored in dry state without losing their protective properties for periods up to 2 weeks.

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    Supporting Information

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    Table containing P-values of t-tests comparing EG6 SAMs to poly(CBMA) films. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cited By

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    This article is cited by 19 publications.

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    Langmuir

    Cite this: Langmuir 2011, 27, 17, 10800–10804
    Click to copy citationCitation copied!
    https://doi.org/10.1021/la201066y
    Published June 28, 2011
    Copyright © 2011 American Chemical Society
    Request reuse permissions

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