Plasma-Enhanced Copolymerization of Amino Acid and Synthetic Monomers
- Kyle D. Anderson ,
- Seth L. Young ,
- Hao Jiang ,
- Rachel Jakubiak ,
- Timothy J. Bunning ,
- Rajesh R. Naik , and
- Vladimir V. Tsukruk
Abstract

In this paper we report the use of plasma-enhanced chemical vapor deposition (PECVD) for the simultaneous deposition and copolymerization of an amino acid with other organic and inorganic monomers. We investigate the fundamental effects of plasma-enhanced copolymerization on different material chemistries in stable ultrathin coatings of mixed composition with an amino acid component. This study serves to determine the feasibility of a direct, facile method for integrating biocompatible/active materials into robust polymerized coatings with the ability to plasma copolymerize a biological molecule (l-tyrosine) with different synthetic materials in a dry, one-step process to form ultrathin coatings of mixed composition. This process may lead to a method of interfacing biologic systems with synthetic materials as a way to enhance the biomaterial–tissue interface and preserve biological activity within composite films.
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