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Microfluidic Fabrication of Stable Gas-Filled Microcapsules for Acoustic Contrast Enhancement

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School of Engineering and Applied Sciences and Department of Physics, Harvard University, 29 Oxford Street, Cambridge, Massachusetts 02138, United States
Department of Chemistry, University of North Carolina at Chapel Hill, UNC Chapel Hill, North Carolina 27599, United States
§ Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, South Korea
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27599, United States
Department of Chemical Engineering, Nazarbayev University, Astana, Kazakhstan
Cite this: Langmuir 2013, 29, 40, 12352–12357
Publication Date (Web):September 2, 2013
https://doi.org/10.1021/la402598p
Copyright © 2013 American Chemical Society

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    Abstract

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    We introduce a facile approach for the production of gas-filled microcapsules designed to withstand high pressures. We exploit microfluidics to fabricate water-filled microcapsules that are then externally triggered to become gas-filled, thus making them more echogenic. In addition, the gas-filled microcapsules have a solid polymer shell making them resistant to pressure-induced buckling, which makes them more mechanically robust than traditional prestabilized microbubbles; this should increase the potential of their utility for acoustic imaging of porous media with high hydrostatic pressures such as oil reservoirs.

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