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Specific Ion Binding to Macromolecules:  Effects of Hydrophobicity and Ion Pairing

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Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, and Center for Biomolecules and Complex Molecular Systems, Flamingovo nám. 2, CZ-16610 Prague 6, Czech Republic
Cite this: Langmuir 2008, 24, 7, 3387–3391
Publication Date (Web):February 23, 2008
https://doi.org/10.1021/la7034104
Copyright © 2008 American Chemical Society
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    Abstract

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    Using molecular dynamics simulations in an explicit aqueous solvent, we examine the binding of fluoride versus iodide to a spherical macromolecule with both hydrophobic and positively charged patches. Rationalizing our observations, we divide the ion association interaction into two mechanisms:  (1) poorly solvated iodide ions are attracted to hydrophobic surface patches, while (2) the strongly solvated fluoride and to a minor extent also iodide bind via cation−anion interactions. Quantitatively, the binding affinities vary significantly with the accessibility of the charged groups as well as the surface potential; therefore, we expect the ion−macromolecule association to be modulated by the local surface characteristics of the (bio-)macromolecule. The observed cation−anion pairing preference is in excellent agreement with experimental data.

    *

     To whom correspondence should be addressed. E-mail:  mikael.lund@ uochb.cas.cz.

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    68. Md. Nazrul Islam, Komol Kanta Sharker, Khokan Chandra Sarker. Salt-Induced Modulation of the Krafft Temperature and Critical Micelle Concentration of Benzyldimethylhexadecylammonium Chloride. Journal of Surfactants and Detergents 2015, 18 (4) , 651-659. https://doi.org/10.1007/s11743-015-1696-4
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    71. Goutam Ghosh. Counterion effects in protein nanoparticle electrostatic binding: A theoretical study. Colloids and Surfaces B: Biointerfaces 2015, 128 , 23-27. https://doi.org/10.1016/j.colsurfb.2015.02.015
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    74. Junjie Shen, Andrea Schäfer. Removal of fluoride and uranium by nanofiltration and reverse osmosis: A review. Chemosphere 2014, 117 , 679-691. https://doi.org/10.1016/j.chemosphere.2014.09.090
    75. Qiang Shao, Jinan Wang, Weiliang Zhu. On the influence of the mixture of denaturants on protein structure stability: A molecular dynamics study. Chemical Physics 2014, 441 , 38-46. https://doi.org/10.1016/j.chemphys.2014.07.006
    76. Y. V. Kalyuzhnyi, V. Vlachy. Model for a mixture of macroions, counterions, and co-ions in a waterlike fluid. Physical Review E 2014, 90 (1) https://doi.org/10.1103/PhysRevE.90.012308
    77. Jordan W. Bye, Lauren Platts, Robert J. Falconer. Biopharmaceutical liquid formulation: a review of the science of protein stability and solubility in aqueous environments. Biotechnology Letters 2014, 36 (5) , 869-875. https://doi.org/10.1007/s10529-013-1445-6
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    79. Epameinondas Leontidis, Maria Christoforou, Chara Georgiou, Thomas Delclos. The ion–lipid battle for hydration water and interfacial sites at soft-matter interfaces. Current Opinion in Colloid & Interface Science 2014, 19 (1) , 2-8. https://doi.org/10.1016/j.cocis.2014.02.003
    80. Lvdan Liu, Yang Shi, Chang Liu, Tao Wang, Guangming Liu, Guangzhao Zhang. Insight into the amplification by methylated urea of the anion specificity of macromolecules. Soft Matter 2014, 10 (16) , 2856. https://doi.org/10.1039/c3sm52778f
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    82. Linjie Han, Suk-Joon Hyung, Brandon T. Ruotolo. Dramatically stabilizing multiprotein complex structure in the absence of bulk water using tuned Hofmeister salts. Faraday Discuss. 2013, 160 , 371-388. https://doi.org/10.1039/C2FD20099F
    83. Shahar Sukenik, Liel Sapir, Regina Gilman-Politi, Daniel Harries. Diversity in the mechanisms of cosolute action on biomolecular processes. Faraday Discuss. 2013, 160 , 225-237. https://doi.org/10.1039/C2FD20101A
    84. Hongbo Du, Xianghong Qian. The Interactions between Salt Ions and Thermo-Responsive Poly (N-Isopropylacrylamide) from Molecular Dynamics Simulations. 2012, 229-242. https://doi.org/10.1002/9781118389553.ch10
    85. Pengyu Ren, Jaehun Chun, Dennis G. Thomas, Michael J. Schnieders, Marcelo Marucho, Jiajing Zhang, Nathan A. Baker. Biomolecular electrostatics and solvation: a computational perspective. Quarterly Reviews of Biophysics 2012, 45 (4) , 427-491. https://doi.org/10.1017/S003358351200011X
    86. Kim D. Collins. Why continuum electrostatics theories cannot explain biological structure, polyelectrolytes or ionic strength effects in ion–protein interactions. Biophysical Chemistry 2012, 167 , 43-59. https://doi.org/10.1016/j.bpc.2012.04.002
    87. Xiuhong Liu, Peng Zhou, Zhicai Shang. A systematical comparison of DFT methods in reproducing the interaction energies of halide series with protein moieties. Journal of Molecular Modeling 2012, 18 (5) , 2079-2098. https://doi.org/10.1007/s00894-011-1232-z
    88. Magdalena Kowacz, Abhik Mukhopadhyay, Ana Luísa Carvalho, José M. S. S. Esperança, Maria J. Romão, Luís Paulo N. Rebelo. Hofmeister effects of ionic liquids in protein crystallization: Direct and water-mediated interactions. CrystEngComm 2012, 14 (15) , 4912. https://doi.org/10.1039/c2ce25129a
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    90. V. A. Kolombet, A. I. Frolov. Na+/K+ selectivity in the formation of ion pairs in aqueous solutions. Russian Journal of Physical Chemistry B 2010, 4 (6) , 875-882. https://doi.org/10.1134/S1990793110060011
    91. . Specific ion effects. 2010, 146-231. https://doi.org/10.1017/CBO9780511811531.008
    92. Yanjie Zhang, Paul S. Cremer. Chemistry of Hofmeister Anions and Osmolytes. Annual Review of Physical Chemistry 2010, 61 (1) , 63-83. https://doi.org/10.1146/annurev.physchem.59.032607.093635
    93. I Kalcher, D Horinek, R R Netz, J Dzubiella. Ion specific correlations in bulk and at biointerfaces. Journal of Physics: Condensed Matter 2009, 21 (42) , 424108. https://doi.org/10.1088/0953-8984/21/42/424108
    94. Robert M. Onorato, Dale E. Otten, Richard J. Saykally. Adsorption of thiocyanate ions to the dodecanol/water interface characterized by UV second harmonic generation. Proceedings of the National Academy of Sciences 2009, 106 (36) , 15176-15180. https://doi.org/10.1073/pnas.0904800106
    95. Yanjie Zhang, Paul S. Cremer. The inverse and direct Hofmeister series for lysozyme. Proceedings of the National Academy of Sciences 2009, 106 (36) , 15249-15253. https://doi.org/10.1073/pnas.0907616106
    96. E.R.A. Lima, M. Boström, E.C. Biscaia, F.W. Tavares, W. Kunz. Ion specific forces between charged self-assembled monolayers explained by modified DLVO theory. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2009, 346 (1-3) , 11-15. https://doi.org/10.1016/j.colsurfa.2009.05.017
    97. Immanuel Kalcher, Joachim Dzubiella. Structure-thermodynamics relation of electrolyte solutions. The Journal of Chemical Physics 2009, 130 (13) https://doi.org/10.1063/1.3097530
    98. Maxim V. Fedorov, Jonathan M. Goodman, Stephan Schumm. The effect of sodium chloride on poly- l -glutamate conformation. Chem. Commun. 2009, 12 (8) , 896-898. https://doi.org/10.1039/B816055D
    99. Mikael Lund, Pavel Jungwirth. Patchy proteins, anions and the Hofmeister series. Journal of Physics: Condensed Matter 2008, 20 (49) , 494218. https://doi.org/10.1088/0953-8984/20/49/494218
    100. Xiaofei Li, S. Lettieri, N. Wentzel, J. D. Gunton. Phase diagram of a model of nanoparticles in electrolyte solutions. The Journal of Chemical Physics 2008, 129 (16) https://doi.org/10.1063/1.2999608
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