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Plasma Surface Modification of Cyclo-olefin Polymers and Its Application to Lateral Flow Bioassays

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Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland
Research Centre in Physics of Matter and Radiation (PMR), University of Namur (FUNDP), 61 rue de Bruxelles, B-5000 Namur, Belgium
§ School of Physical Sciences, Dublin City University, Dublin 9, Ireland
National Centre for Plasma Science and Technology, Dublin City University, Dublin 9, Ireland
*Corresponding author. E-mail: [email protected]
Cite this: Langmuir 2009, 25, 18, 11155–11161
Publication Date (Web):July 9, 2009
https://doi.org/10.1021/la901455g
Copyright © 2009 American Chemical Society

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    Abstract

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    The modification of cyclo-olefin polymer Zeonor by plasma-enhanced chemical vapor deposition to form a silica-like surface and evaluation of its application for lateral flow bioassays applications are discussed in this study. The SiOx layer was extensively characterized using contact angle measurements, atomic force microscopy, and Fourier transform infrared spectroscopy in attenuated total internal reflectance mode where the presence of a uniform SiOx film was clearly identified. The SiOx modification resulted in a surface with enhanced wettability and excellent fluidic properties when combined with a hot-embossed micropillar capillary fill-based substrate. The SiOx surface also had the ability to accelerate the clotting of human plasma, which may have application in certain types of blood coagulation assays.

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