ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Plasma Surface Modification of Cyclo-olefin Polymers and Its Application to Lateral Flow Bioassays

View Author Information
Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland
Research Centre in Physics of Matter and Radiation (PMR), University of Namur (FUNDP), 61 rue de Bruxelles, B-5000 Namur, Belgium
§ School of Physical Sciences, Dublin City University, Dublin 9, Ireland
National Centre for Plasma Science and Technology, Dublin City University, Dublin 9, Ireland
*Corresponding author. E-mail: [email protected]
Cite this: Langmuir 2009, 25, 18, 11155–11161
Publication Date (Web):July 9, 2009
Copyright © 2009 American Chemical Society

    Article Views





    Other access options


    Abstract Image

    The modification of cyclo-olefin polymer Zeonor by plasma-enhanced chemical vapor deposition to form a silica-like surface and evaluation of its application for lateral flow bioassays applications are discussed in this study. The SiOx layer was extensively characterized using contact angle measurements, atomic force microscopy, and Fourier transform infrared spectroscopy in attenuated total internal reflectance mode where the presence of a uniform SiOx film was clearly identified. The SiOx modification resulted in a surface with enhanced wettability and excellent fluidic properties when combined with a hot-embossed micropillar capillary fill-based substrate. The SiOx surface also had the ability to accelerate the clotting of human plasma, which may have application in certain types of blood coagulation assays.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.


    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Cited By

    This article is cited by 17 publications.

    1. Taiki Yamate, Kazuhisa Kumazawa, Hiroshi Suzuki, and Motohiro Akazome . CH/π Interactions for Macroscopic Interfacial Adhesion Design. ACS Macro Letters 2016, 5 (7) , 858-861.
    2. N. Ktari, P. Poncet, H. Sénéchal, L. Malaquin, F. Kanoufi, and C. Combellas . Patterning of Polystyrene by Scanning Electrochemical Microscopy. Biological Applications to Cell Adhesion. Langmuir 2010, 26 (22) , 17348-17356.
    3. Magdalena M. Dudek, Tomas L. Lindahl and Anthony J. Killard . Development of a Point of Care Lateral Flow Device for Measuring Human Plasma Fibrinogen. Analytical Chemistry 2010, 82 (5) , 2029-2035.
    4. Pedro Silva Couto, Samuel A. Molina, Denis O’Sullivan, Liam O’Neill, Alexander M. Lyness, Qasim A. Rafiq. Understanding the impact of bioactive coating materials for human mesenchymal stromal cells and implications for manufacturing. Biotechnology Letters 2023, 45 (8) , 1013-1027.
    5. Zhiqing Xiao, Lexin Sun, Yuqian Yang, Zitao Feng, Sihan Dai, Hao Yang, Xingwei Zhang, Chia-Lin Sheu, Weijin Guo. High-Performance Passive Plasma Separation on OSTE Pillar Forest. Biosensors 2021, 11 (10) , 355.
    6. Weijin Guo, Jonas Hansson, Wouter van der Wijngaart. Capillary pumping independent of the liquid surface energy and viscosity. Microsystems & Nanoengineering 2018, 4 (1)
    7. Felipe Soberon. Surface activation of cyclo olefin polymer by oxygen plasma discharge: a molecular dynamics study. Modelling and Simulation in Materials Science and Engineering 2014, 22 (5) , 055020.
    8. Stefan Haubenwallner, Matthias Katschnig, Ulrike Fasching, Silke Patz, Christa Trattnig, Natascha Andraschek, Gerda Grünbacher, Markus Absenger, Stephan Laske, Clemens Holzer, Werner Balika, Manuela Wagner, Ute Schäfer. Effects of the polymeric niche on neural stem cell characteristics during primary culturing. Journal of Materials Science: Materials in Medicine 2014, 25 (5) , 1339-1355.
    9. Herin Oh, Alec Cerchiari, Desirée Sørensen, Timothy Mon, Cassandra L. Smith. Rolling Circle Amplification on Biotin-Streptavidin Complexes Immobilized to Activated Cyclic Polyolefin Surfaces. Materials Sciences and Applications 2013, 04 (09) , 538-548.
    10. Saira Nayab, Wonjin Park, Hyun Yul Woo, Ick Kyung Sung, Woon Sung Hwang, Hyosun Lee. Synthesis and characterization of novel tungsten complexes and their activity in the ROMP of cyclic olefins. Polyhedron 2012, 42 (1) , 102-109.
    11. Magdalena M. Dudek, Nigel J. Kent, Pan Gu, Z. Hugh Fan, Anthony J. Killard. Development of a fluorescent method for detecting the onset of coagulation in human plasma on microstructured lateral flow platforms. The Analyst 2011, 136 (9) , 1816.
    12. Ke Liu, Z. Hugh Fan. Thermoplastic microfluidic devices and their applications in protein and DNA analysis. The Analyst 2011, 136 (7) , 1288.
    13. R.P. Gandhiraman, V. Gubala, Le Cao Hoai Nam, C. Volcke, C. Doyle, B. James, S. Daniels, D.E. Williams. Deposition of chemically reactive and repellent sites on biosensor chips for reduced non-specific binding. Colloids and Surfaces B: Biointerfaces 2010, 79 (1) , 270-275.
    14. Cedric Volcke, Ram Prasad Gandhiraman, Vladimir Gubala, Colin Doyle, G. Fonder, Paul A. Thiry, Attilio A. Cafolla, Bryony James, David E. Williams. Plasma functionalization of AFM tips for measurement of chemical interactions. Journal of Colloid and Interface Science 2010, 348 (2) , 322-328.
    15. L Riegger, M M Mielnik, A Gulliksen, D Mark, J Steigert, S Lutz, M Clad, R Zengerle, P Koltay, J Hoffmann. Dye-based coatings for hydrophobic valves and their application to polymer labs-on-a-chip. Journal of Micromechanics and Microengineering 2010, 20 (4) , 045021.
    16. C. Volcke, R.P. Gandhiraman, L. Basabe-Desmonts, M. Iacono, V. Gubala, F. Cecchet, A.A. Cafolla, D.E. Williams. Protein pattern transfer for biosensor applications. Biosensors and Bioelectronics 2010, 25 (6) , 1295-1300.
    17. Ram P. Gandhiraman*, Cedric Volcke, Vladimir Gubala, Colin Doyle, Lourdes Basabe-Desmonts, Christian Dotzler, Michael F. Toney, Marcello Iacono, Robert I. Nooney, Stephen Daniels, Bryony James, David E. Williams. High efficiency amine functionalization of cycloolefin polymer surfaces for biodiagnostics. Journal of Materials Chemistry 2010, 20 (20) , 4116.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect