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Low Power, Biologically Benign NIR Light Triggers Polymer Disassembly

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Skaggs School Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, Materials Science and Engineering and Biomedical Sciences Programs, University of California at San Diego, La Jolla, California 92093, United States
E-mail: [email protected]
Cite this: Macromolecules 2011, 44, 21, 8590–8597
Publication Date (Web):September 30, 2011
https://doi.org/10.1021/ma201850q
Copyright © 2011 American Chemical Society
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    Near infrared (NIR) irradiation can penetrate up to 10 cm deep into tissues and be remotely applied with high spatial and temporal precision. Despite its potential for various medical and biological applications, there is a dearth of biomaterials that are responsive at this wavelength region. Herein we report a polymeric material that is able to disassemble in response to biologically benign levels of NIR irradiation upon two-photon absorption. The design relies on the photolysis of the multiple pendant 4-bromo7-hydroxycoumarin protecting groups to trigger a cascade of cyclization and rearrangement reactions leading to the degradation of the polymer backbone. The new material undergoes a 50% Mw loss after 25 s of ultraviolet (UV) irradiation by single photon absorption and 21 min of NIR irradiation via two-photon absorption. Most importantly, even NIR irradiation at a biologically benign laser power is sufficient to cause significant polymer disassembly. Furthermore, this material is well tolerated by cells both before and after degradation. These results demonstrate for the first time a NIR sensitive material with potential to be used for in vivo applications.

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    Details for the synthesis of compounds 2, 3, 4, 9 and 10 and cytotoxicity experiments. This material is available free of charge via the Internet at http://pubs.acs.org/.

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    8. Alona Shagan, Tsuf Croitoru-Sadger, Enav Corem-Salkmon, and Boaz Mizrahi . Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release. ACS Applied Materials & Interfaces 2018, 10 (4) , 4131-4139. https://doi.org/10.1021/acsami.7b17481
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    10. Matthew J. Feeney, Xiaoran Hu, Rati Srinivasan, Nhi Van, Martin Hunter, Irene Georgakoudi, and Samuel W. Thomas, III . UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups. Langmuir 2017, 33 (41) , 10877-10885. https://doi.org/10.1021/acs.langmuir.7b01469
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    12. Xiaohui Xu, Bo Bai, Honglun Wang, and Yourui Suo . A Near-Infrared and Temperature-Responsive Pesticide Release Platform through Core–Shell Polydopamine@PNIPAm Nanocomposites. ACS Applied Materials & Interfaces 2017, 9 (7) , 6424-6432. https://doi.org/10.1021/acsami.6b15393
    13. Yingkai Liang, Linqing Li, Rebecca A. Scott, and Kristi L. Kiick . 50th Anniversary Perspective: Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry. Macromolecules 2017, 50 (2) , 483-502. https://doi.org/10.1021/acs.macromol.6b02389
    14. Michal E. Roth, Ori Green, Samer Gnaim, and Doron Shabat . Dendritic, Oligomeric, and Polymeric Self-Immolative Molecular Amplification. Chemical Reviews 2016, 116 (3) , 1309-1352. https://doi.org/10.1021/acs.chemrev.5b00372
    15. Caroline de Gracia Lux, Jacques Lux, Guillaume Collet, Sha He, Minnie Chan, Jason Olejniczak, Alexandra Foucault-Collet, and Adah Almutairi . Short Soluble Coumarin Crosslinkers for Light-Controlled Release of Cells and Proteins from Hydrogels. Biomacromolecules 2015, 16 (10) , 3286-3296. https://doi.org/10.1021/acs.biomac.5b00950
    16. Mei-Chin Chen, Ming-Hung Ling, Kuan-Wen Wang, Zhi-Wei Lin, Bo-Hung Lai, and Dong-Hwang Chen . Near-Infrared Light-Responsive Composite Microneedles for On-Demand Transdermal Drug Delivery. Biomacromolecules 2015, 16 (5) , 1598-1607. https://doi.org/10.1021/acs.biomac.5b00185
    17. Kimy Yeung, Hyungwoo Kim, Hemakesh Mohapatra, and Scott T. Phillips . Surface-Accessible Detection Units in Self-Immolative Polymers Enable Translation of Selective Molecular Detection Events into Amplified Responses in Macroscopic, Solid-State Plastics. Journal of the American Chemical Society 2015, 137 (16) , 5324-5327. https://doi.org/10.1021/jacs.5b02799
    18. Congcong Zhu, Chi Ninh, and Christopher J. Bettinger . Photoreconfigurable Polymers for Biomedical Applications: Chemistry and Macromolecular Engineering. Biomacromolecules 2014, 15 (10) , 3474-3494. https://doi.org/10.1021/bm500990z
    19. Patricia Gumbley, Damla Koylu, Robert H. Pawle, Bond Umezuruike, Elise Spedden, Cristian Staii, and Samuel W. Thomas, III . Wavelength-Selective Disruption and Triggered Release with Photolabile Polyelectrolyte Multilayers. Chemistry of Materials 2014, 26 (3) , 1450-1456. https://doi.org/10.1021/cm403979p
    20. Jason Olejniczak, Jagadis Sankaranarayanan, Mathieu L. Viger, and Adah Almutairi . Highest Efficiency Two-Photon Degradable Copolymer for Remote Controlled Release. ACS Macro Letters 2013, 2 (8) , 683-687. https://doi.org/10.1021/mz400256x
    21. Caroline de Gracia Lux and Adah Almutairi . Intramolecular Cyclization for Stimuli-Controlled Depolymerization of Polycaprolactone Particles Leading to Disassembly and Payload Release. ACS Macro Letters 2013, 2 (5) , 432-435. https://doi.org/10.1021/mz400129h
    22. Shuangyi Sun, Elaheh A. Chamsaz, and Abraham Joy . Photoinduced Polymer Chain Scission of Alkoxyphenacyl Based Polycarbonates. ACS Macro Letters 2012, 1 (10) , 1184-1188. https://doi.org/10.1021/mz3002947
    23. Gregory I. Peterson, Michael B. Larsen, and Andrew J. Boydston . Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers. Macromolecules 2012, 45 (18) , 7317-7328. https://doi.org/10.1021/ma300817v
    24. Caroline de Gracia Lux, Cathryn L. McFearin, Shivanjali Joshi-Barr, Jagadis Sankaranarayanan, Nadezda Fomina, and Adah Almutairi . Single UV or Near IR Triggering Event Leads to Polymer Degradation into Small Molecules. ACS Macro Letters 2012, 1 (7) , 922-926. https://doi.org/10.1021/mz3002403
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    26. Yue Zhao . Light-Responsive Block Copolymer Micelles. Macromolecules 2012, 45 (9) , 3647-3657. https://doi.org/10.1021/ma300094t
    27. Kyle M. Schmid, Lasse Jensen, and Scott T. Phillips . A Self-Immolative Spacer That Enables Tunable Controlled Release of Phenols under Neutral Conditions. The Journal of Organic Chemistry 2012, 77 (9) , 4363-4374. https://doi.org/10.1021/jo300400q
    28. Tuan Liu, Bingkun Bao, Yuzhan Li, Qiuning Lin, Linyong Zhu. Photo-responsive polymers based on ο-Nitrobenzyl derivatives: from structural design to applications. Progress in Polymer Science 2023, 146 , 101741. https://doi.org/10.1016/j.progpolymsci.2023.101741
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    48. Yue Xiao, Xuyu Tan, Zhaohui Li, Ke Zhang. Self-immolative polymers in biomedicine. Journal of Materials Chemistry B 2020, 8 (31) , 6697-6709. https://doi.org/10.1039/D0TB01119C
    49. Fabian Becker, Marvin Klaiber, Matthias Franzreb, Stefan Bräse, Joerg Lahann. On Demand Light‐Degradable Polymers Based on 9,10‐Dialkoxyanthracenes. Macromolecular Rapid Communications 2020, 41 (15) https://doi.org/10.1002/marc.202000314
    50. Ann-Kathrin Müller, Dimitri Jung, Jingjiang Sun, Dirk Kuckling. Synthesis and characterization of light-degradable bromocoumarin functionalized polycarbonates. Polymer Chemistry 2020, 11 (3) , 721-733. https://doi.org/10.1039/C9PY01405E
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    52. Wenfeng Wei, Xiaoyuan Zhang, Shan Zhang, Gang Wei, Zhiqiang Su. Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review. Materials Science and Engineering: C 2019, 104 , 109891. https://doi.org/10.1016/j.msec.2019.109891
    53. Wei Zhao, Yongmei Zhao, Qingfu Wang, Tianqing Liu, Jingjiang Sun, Run Zhang. Remote Light‐Responsive Nanocarriers for Controlled Drug Delivery: Advances and Perspectives. Small 2019, 15 (45) https://doi.org/10.1002/smll.201903060
    54. Tao Chen, Huining Wang, Yingying Chu, Cyrille Boyer, Jingquan Liu, Jiangtao Xu. Photo‐Induced Depolymerisation: Recent Advances and Future Challenges. ChemPhotoChem 2019, 3 (11) , 1059-1076. https://doi.org/10.1002/cptc.201900166
    55. Bijay P. Chhetri, Alokita Karmakar, Anindya Ghosh. Recent Advancements in Ln‐Ion‐Based Upconverting Nanomaterials and Their Biological Applications. Particle & Particle Systems Characterization 2019, 36 (8) https://doi.org/10.1002/ppsc.201900153
    56. Qihong Liu, Hao Wang, Guotao Li, Miaochang Liu, Jinchang Ding, Xiaobo Huang, Wenxia Gao, Wu Huayue. A photocleavable low molecular weight hydrogel for light-triggered drug delivery. Chinese Chemical Letters 2019, 30 (2) , 485-488. https://doi.org/10.1016/j.cclet.2018.06.009
    57. Miguel Moreno Raja, Pei Qi Lim, Yee Shan Wong, Gordon M. Xiong, Yiming Zhang, Subbu Venkatraman, Yingying Huang. Polymeric Nanomaterials. 2019, 557-653. https://doi.org/10.1016/B978-0-12-814033-8.00018-7
    58. Muhammad Bilal, Tahir Rasheed, Abaid Ullah, Hafiz M. N. Iqbal. Valorization of Green and Sustainable Advanced Materials from A Biomed Perspective – Potential Applications. 2018, 19-47. https://doi.org/10.1002/9781119528463.ch2
    59. Lu Yang, Houliang Tang, Hao Sun. Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies. Micromachines 2018, 9 (6) , 296. https://doi.org/10.3390/mi9060296
    60. M. Gisbert-Garzarán, M. Manzano, M. Vallet-Regí. Self-immolative chemistry in nanomedicine. Chemical Engineering Journal 2018, 340 , 24-31. https://doi.org/10.1016/j.cej.2017.12.098
    61. Florica Adriana Jerca, Valentin Victor Jerca, Izabela-Cristina Stancu. Development and Characterization of Photoresponsive Polymers. 2018, 3-47. https://doi.org/10.1007/978-3-319-75801-5_1
    62. Shantanu V. Lale, Veena Koul. Stimuli-Responsive Polymeric Nanoparticles for Cancer Therapy. 2018, 27-54. https://doi.org/10.1007/978-981-10-6080-9_2
    63. Tahir Rasheed, Muhammad Bilal, Nedal Y. Abu-Thabit, Hafiz M.N. Iqbal. The smart chemistry of stimuli-responsive polymeric carriers for target drug delivery applications. 2018, 61-99. https://doi.org/10.1016/B978-0-08-101997-9.00003-5
    64. Chunfeng Hang, Yan Zou, Yinan Zhong, Zhiyuan Zhong, Fenghua Meng. NIR and UV-responsive degradable hyaluronic acid nanogels for CD44-targeted and remotely triggered intracellular doxorubicin delivery. Colloids and Surfaces B: Biointerfaces 2017, 158 , 547-555. https://doi.org/10.1016/j.colsurfb.2017.07.041
    65. Redouane Bouchaala, Nicolas Anton, Halina Anton, Thierry Vandamme, Julien Vermot, Djabi Smail, Yves Mély, Andrey S. Klymchenko. Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo. Colloids and Surfaces B: Biointerfaces 2017, 156 , 414-421. https://doi.org/10.1016/j.colsurfb.2017.05.035
    66. Xiuli Yue, Qiang Zhang, Zhifei Dai. Near-infrared light-activatable polymeric nanoformulations for combined therapy and imaging of cancer. Advanced Drug Delivery Reviews 2017, 115 , 155-170. https://doi.org/10.1016/j.addr.2017.04.007
    67. Chase S Linsley, Benjamin M Wu. Recent advances in light-responsive on-demand drug-delivery systems. Therapeutic Delivery 2017, 8 (2) , 89-107. https://doi.org/10.4155/tde-2016-0060
    68. Theodore Manouras, Maria Vamvakaki. Field responsive materials: photo-, electro-, magnetic- and ultrasound-sensitive polymers. Polymer Chemistry 2017, 8 (1) , 74-96. https://doi.org/10.1039/C6PY01455K
    69. Yawei Sun, Yanyun Ji, Haiyan Yu, Dong Wang, Meiwen Cao, Jiqian Wang. Near-infrared light-sensitive liposomes for controlled release. RSC Advances 2016, 6 (84) , 81245-81249. https://doi.org/10.1039/C6RA18702A
    70. Hyun Jun Cho, Minsub Chung, Min Suk Shim. Engineered photo-responsive materials for near-infrared-triggered drug delivery. Journal of Industrial and Engineering Chemistry 2015, 31 , 15-25. https://doi.org/10.1016/j.jiec.2015.07.016
    71. Montserrat Colilla, Alejandro Baeza, María Vallet‐Regí. Mesoporous Silica Nanoparticles for Drug Delivery and Controlled Release Applications. 2015, 1309-1344. https://doi.org/10.1002/9783527670819.ch42
    72. Alina Y. Rwei, Weiping Wang, Daniel S. Kohane. Photoresponsive nanoparticles for drug delivery. Nano Today 2015, 10 (4) , 451-467. https://doi.org/10.1016/j.nantod.2015.06.004
    73. Ahmed Alouane, Raphaël Labruère, Thomas Le Saux, Frédéric Schmidt, Ludovic Jullien. Self‐Immolative Spacers: Kinetic Aspects, Structure–Property Relationships, and Applications. Angewandte Chemie International Edition 2015, 54 (26) , 7492-7509. https://doi.org/10.1002/anie.201500088
    74. Ahmed Alouane, Raphaël Labruère, Thomas Le Saux, Frédéric Schmidt, Ludovic Jullien. Selbstzerlegende Spacer: kinetische Aspekte, Struktur‐Eigenschafts‐Beziehungen und Anwendungen. Angewandte Chemie 2015, 127 (26) , 7600-7619. https://doi.org/10.1002/ange.201500088
    75. Joshua A. Kaitz, Olivia P. Lee, Jeffrey S. Moore. Depolymerizable polymers: preparation, applications, and future outlook. MRS Communications 2015, 5 (2) , 191-204. https://doi.org/10.1557/mrc.2015.28
    76. Wei Wang, Jiaping Lin, Chunhua Cai, Shaoliang Lin. Optical properties of amphiphilic copolymer-based self-assemblies. European Polymer Journal 2015, 65 , 112-131. https://doi.org/10.1016/j.eurpolymj.2015.01.023
    77. Julián Bergueiro, Marcelo Calderón. Thermoresponsive Nanodevices in Biomedical Applications. Macromolecular Bioscience 2015, 15 (2) , 183-199. https://doi.org/10.1002/mabi.201400362
    78. Mei-Chin Chen, Kuan-Wen Wang, Dong-Hwang Chen, Ming-Hung Ling, Chih-Ying Liu. Remotely triggered release of small molecules from LaB6@SiO2-loaded polycaprolactone microneedles. Acta Biomaterialia 2015, 13 , 344-353. https://doi.org/10.1016/j.actbio.2014.11.040
    79. JIANLIN YUAN, XIAOMIN YI, FEI YAN, FULI WANG, WEIJUN QIN, GUOJUN WU, XIAOJIAN YANG, CHEN SHAO, LELAND W.K. CHUNG. Near-infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes. Molecular Medicine Reports 2015, 11 (2) , 821-828. https://doi.org/10.3892/mmr.2014.2815
    80. Roberta Cassano, Sonia Trombino. Drug Delivery Systems: Smart Polymeric Materials. 2015, 341-370. https://doi.org/10.1007/978-3-319-12478-0_12
    81. H. Lu, W.M. Huang. Chemo-responsive shape-memory polymers for biomedical applications. 2015, 99-132. https://doi.org/10.1016/B978-0-85709-698-2.00006-4
    82. Carina I. C. Crucho. Stimuli‐Responsive Polymeric Nanoparticles for Nanomedicine. ChemMedChem 2015, 10 (1) , 24-38. https://doi.org/10.1002/cmdc.201402290
    83. S. Lütje, M. Rijpkema, W. Helfrich, W. J. G. Oyen, O. C. Boerman. Targeted Radionuclide and Fluorescence Dual-modality Imaging of Cancer: Preclinical Advances and Clinical Translation. Molecular Imaging and Biology 2014, 16 (6) , 747-755. https://doi.org/10.1007/s11307-014-0747-y
    84. Daniel Wehrung, Elaheh A. Chamsaz, Abraham Joy, Moses O. Oyewumi. Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates. European Journal of Pharmaceutics and Biopharmaceutics 2014, 88 (3) , 962-972. https://doi.org/10.1016/j.ejpb.2014.07.011
    85. Xintao Shuai, Du Cheng. Stimulation‐Sensitive Drug Delivery Systems. 2014, 305-330. https://doi.org/10.1002/9783527672752.ch12
    86. Larisa-Emilia Cheran, Alin Cheran, Michael Thompson. Biomimicry and Materials in Medicine. 2014, 1-25. https://doi.org/10.1039/9781849737074-00001
    87. Daniel Wehrung, Moses Oyewumi. Cytotoxicity of Stimuli-Responsive Nanomaterials: Predicting Clinical Viability through Robust Biocompatibility Profiles. 2014, 103-116. https://doi.org/10.1201/b17191-5
    88. Susanne Lütje, Mark Rijpkema, Gerben M. Franssen, Giulio Fracasso, Wijnand Helfrich, Annemarie Eek, Wim J. Oyen, Marco Colombatti, Otto C. Boerman. Dual-Modality Image-Guided Surgery of Prostate Cancer with a Radiolabeled Fluorescent Anti-PSMA Monoclonal Antibody. Journal of Nuclear Medicine 2014, 55 (6) , 995-1001. https://doi.org/10.2967/jnumed.114.138180
    89. Anu Puri. Phototriggerable Liposomes: Current Research and Future Perspectives. Pharmaceutics 2014, 6 (1) , 1-25. https://doi.org/10.3390/pharmaceutics6010001
    90. Congcong Zhu, Christopher J. Bettinger. Light-induced remodeling of physically crosslinked hydrogels using near-IR wavelengths. J. Mater. Chem. B 2014, 2 (12) , 1613-1618. https://doi.org/10.1039/C3TB21689F
    91. Rong Tong, Li Tang, Liang Ma, Chunlai Tu, Ryan Baumgartner, Jianjun Cheng. Smart chemistry in polymeric nanomedicine. Chem. Soc. Rev. 2014, 43 (20) , 6982-7012. https://doi.org/10.1039/C4CS00133H
    92. Qi Huang, Tao Liu, Chunyan Bao, Qiuning Lin, Meixin Ma, Linyong Zhu. Light and reductive dual stimuli-responsive PEI nanoparticles: “AND” logic response and controllable release. J. Mater. Chem. B 2014, 2 (21) , 3333-3339. https://doi.org/10.1039/C4TB00087K
    93. Malar A. Azagarsamy, Kristi S. Anseth. Wavelength‐Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins. Angewandte Chemie International Edition 2013, 52 (51) , 13803-13807. https://doi.org/10.1002/anie.201308174
    94. Malar A. Azagarsamy, Kristi S. Anseth. Wavelength‐Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins. Angewandte Chemie 2013, 125 (51) , 14048-14052. https://doi.org/10.1002/ange.201308174
    95. Duy M. Le, Michael A. Tycon, Christopher J. Fecko, Valerie S. Ashby. Near‐infrared activation of semi‐crystalline shape memory polymer nanocomposites. Journal of Applied Polymer Science 2013, 130 (6) , 4551-4557. https://doi.org/10.1002/app.39604
    96. Patricia Gumbley, Xiaoran Hu, John A. Lawrence, Samuel W. Thomas. Photoresponsive Gels Prepared by Ring‐Opening Metathesis Polymerization. Macromolecular Rapid Communications 2013, 34 (23-24) , 1838-1843. https://doi.org/10.1002/marc.201300653
    97. Zhen Wang, Peng Wang, XinJing Tang. Synthesis of Light‐Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release. ChemPlusChem 2013, 78 (10) , 1273-1281. https://doi.org/10.1002/cplu.201300212
    98. Congcong Zhu, Christopher J. Bettinger. Light‐Induced Disintegration of Robust Physically Cross‐Linked Polymer Networks. Macromolecular Rapid Communications 2013, 34 (18) , 1446-1451. https://doi.org/10.1002/marc.201300420
    99. Mathieu L. Viger, Madeleine Grossman, Nadezda Fomina, Adah Almutairi. Low Power Upconverted Near‐IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release. Advanced Materials 2013, 25 (27) , 3733-3738. https://doi.org/10.1002/adma.201300902
    100. Manuel Alatorre-Meda, Carmen Alvarez-Lorenzo, Angel Concheiro, Pablo Taboada. UV and Near-IR Triggered Release from Polymeric Micelles and Nanoparticles. 2013, 304-348. https://doi.org/10.1039/9781849736800-00304
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