ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Triggering Polymeric Nanoparticle Disassembly through the Simultaneous Application of Two Different Stimuli

View Author Information
Chemical Nanoscience Laboratory, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom
Cite this: Macromolecules 2012, 45, 6, 2699–2708
Publication Date (Web):March 14, 2012
Copyright © 2012 American Chemical Society

    Article Views





    Read OnlinePDF (3 MB)
    Supporting Info (1)»


    Abstract Image

    Polymeric nanoparticles whose disassembly into their component polymer chains is triggered by the simultaneous application of two different stimuli are described. Reversible addition–fragmentation chain transfer (RAFT) polymerization was utilized to prepare acrylamide-based linear copolymers displaying pyridyl disulfide appendages and either aldehyde or amine functional groups. These copolymer chains were intermolecularly cross-linked through imine bond formation at pH 8.0 and then through disulfide bond formation to afford polymeric nanoparticles possessing hydrodynamic radii of 76 nm consisting of multiple polymer chains cross-linked through both imine and disulfide bonds. By performing the cross-linking reactions in the presence of the hydrophobic dye Nile Red, it was demonstrated that these polymeric nanoparticles could encapsulate a cargo of small hydrophobic molecules. The disassembly of the polymeric nanoparticles into their component polymer chains was accomplished by lowing the pH to 5.5 in the presence of the disulfide reducing agent tris(2-carboxyethyl)phosphine (TCEP), causing hydrolysis of the imine cross-links and cleavage of the disulfide cross-links, respectively, and demonstrating that the simultaneous application of both low pH and a reducing environment are required to trigger the disassembly process. It was shown that application of either a low pH or the application of the reducing agent TCEP does not trigger the disassembly of the polymeric nanoparticle as there is sufficient density of the remaining imine or disulfide cross-links which are able to maintain the structural integrity of the polymeric nanoparticle. The formation and disassembly processes of these polymeric nanoparticles was monitored by gel permeation chromatography, and the release of the dye was monitored using fluorescence spectroscopy. A 5 kDa poly(ethylene glycol) was grafted onto the polymeric nanoparticle, demonstrating the potential of these polymeric nanoparticles to undergo post-assembly functionalization.

    Supporting Information

    Jump To

    1H NMR spectra of M1, M2, M3, P1, P2a, and P2b; 1H NMR spectroscopy evidence of 2-pyridinethione release during N2 formation. This material is available free of charge via the Internet at

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system:

    Cited By

    This article is cited by 108 publications.

    1. Matteo Andrea Lucherelli, Antoine Duval, Luc Averous. Combining Associative and Dissociative Dynamic Linkages in Covalent Adaptable Networks from Biobased 2,5-Furandicarboxaldehyde. ACS Sustainable Chemistry & Engineering 2023, 11 (6) , 2334-2344.
    2. Subrata Santra, Arpan Ghosh, Arun Mondal, Sk. Mursed Ali, Dishan Das, Kishor Sarkar, Lisa Roy, Mijanur Rahaman Molla. Stabilizing Entropically Driven Self-Assembly of Self-Immolative Polyurethanes in Water: A Strategy for Tunable Encapsulation Stability and Controlled Cargo Release. ACS Applied Polymer Materials 2022, 4 (10) , 7614-7625.
    3. Julien Crozzolo, Georges J. M. Formon, Mickaël Pomes-Hadda, Stefano Aime, Stéphane Jouenne, Renaud Nicolaÿ. Associative and Thermoresponsive Aqueous Polymer Formulations Based on Imine Chemistry. ACS Applied Polymer Materials 2022, 4 (6) , 4274-4285.
    4. Arman Moini Jazani, Newsha Arezi, Chaitra Shetty, Jung Kwon Oh. Shell-Sheddable/Core-Degradable ABA Triblock Copolymer Nanoassemblies: Synthesis via RAFT and Concurrent ATRP/RAFT Polymerization and Drug Delivery Application. Molecular Pharmaceutics 2022, 19 (6) , 1786-1794.
    5. Emma E. Brotherton, Mark J. Smallridge, Steven P. Armes. Aldehyde-Functional Diblock Copolymer Nano-objects via RAFT Aqueous Dispersion Polymerization. Biomacromolecules 2021, 22 (12) , 5382-5389.
    6. Akifumi Kawamura, Ayaka Harada, Shunsuke Ueno, Takashi Miyata. Weakly Acidic pH and Reduction Dual Stimuli-Responsive Gel Particles. Langmuir 2021, 37 (39) , 11484-11492.
    7. Jakub W. Trzciński, Lucía Morillas-Becerril, Sara Scarpa, Marco Tannorella, Francesco Muraca, Federico Rastrelli, Chiara Castellani, Marny Fedrigo, Annalisa Angelini, Regina Tavano, Emanuele Papini, Fabrizio Mancin. Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors. Biomacromolecules 2021, 22 (2) , 467-480.
    8. Guang Yang, Jie Wang, Yangyang Yan, Zijuan Hai, Zan Hua, Guosong Chen. Multi-Stimuli-Triggered Shape Transformation of Polymeric Filaments Derived from Dynamic Covalent Block Copolymers. Biomacromolecules 2020, 21 (10) , 4159-4168.
    9. Jay M. Korde, Balasubramanian Kandasubramanian. Fundamentals and Effects of Biomimicking Stimuli-Responsive Polymers for Engineering Functions. Industrial & Engineering Chemistry Research 2019, 58 (23) , 9709-9757.
    10. Jiaming Zhuang, Bo Zhao, S. Thayumanavan. Cascaded Step-Growth Polymerization for Functional Polyamides with Diverse Architectures and Stimuli Responsive Characteristics. ACS Macro Letters 2019, 8 (3) , 245-249.
    11. Mahalia A. C. Serrano, Bo Zhao, Huan He, S. Thayumanavan, Richard W. Vachet. Molecular Features Influencing the Release of Peptides from Amphiphilic Polymeric Reverse Micelles. Langmuir 2018, 34 (15) , 4595-4602.
    12. Saikat Maiti, Pousali Samanta, Gargi Biswas, and Dibakar Dhara . Arm-First Approach toward Cross-Linked Polymers with Hydrophobic Domains via Hypervalent Iodine-Mediated Click Chemistry. ACS Omega 2018, 3 (1) , 562-575.
    13. Arman Moini Jazani and Jung Kwon Oh . Dual Location, Dual Acidic pH/Reduction-Responsive Degradable Block Copolymer: Synthesis and Investigation of Ketal Linkage Instability under ATRP Conditions. Macromolecules 2017, 50 (23) , 9427-9436.
    14. Tiziana Fuoco, Daniela Pappalardo, and Anna Finne-Wistrand . Redox-Responsive Disulfide Cross-Linked PLA–PEG Nanoparticles. Macromolecules 2017, 50 (18) , 7052-7061.
    15. Peiwen Liu, Carsten Mai, and Kai Zhang . Formation of Uniform Multi-Stimuli-Responsive and Multiblock Hydrogels from Dialdehyde Cellulose. ACS Sustainable Chemistry & Engineering 2017, 5 (6) , 5313-5319.
    16. Matthias Hartlieb, Tanja Bus, Joachim Kübel, David Pretzel, Stephanie Hoeppener, Meike N. Leiske, Kristian Kempe, Benjamin Dietzek, and Ulrich S. Schubert . Tailoring Cellular Uptake and Fluorescence of Poly(2-oxazoline)-Based Nanogels. Bioconjugate Chemistry 2017, 28 (4) , 1229-1235.
    17. Yunlong Yang, Yan Li, Qiuning Lin, Chunyan Bao, and Linyong Zhu . In Situ Phototriggered Disulfide-Cross-Link Nanoparticles for Drug Delivery. ACS Macro Letters 2016, 5 (3) , 301-305.
    18. Xiaobei Wang, Lin Wang, Shixia Yang, MingMing Zhang, Qingqing Xiong, Hanying Zhao, and Li Liu . Construction of Multifunctionalizable, Core-Cross-Linked Polymeric Nanoparticles via Dynamic Covalent Bond. Macromolecules 2014, 47 (6) , 1999-2009.
    19. Jiaming Zhuang, Reuben Chacko, Diego F. Amado Torres, Hui Wang, and S. Thayumanavan . Dual Stimuli–Dual Response Nanoassemblies Prepared from a Simple Homopolymer. ACS Macro Letters 2014, 3 (1) , 1-5.
    20. Jingyi Li, Shixia Yang, Lin Wang, Xiaobei Wang, and Li Liu . Thermoresponsive Dynamic Covalent Polymers with Tunable Properties. Macromolecules 2013, 46 (17) , 6832-6842.
    21. Min Hee Lee, Zhigang Yang, Choon Woo Lim, Yun Hak Lee, Sun Dongbang, Chulhun Kang, and Jong Seung Kim . Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications. Chemical Reviews 2013, 113 (7) , 5071-5109.
    22. Jing Hao, Yixing Cheng, R. J. K. Udayana Ranatunga, Suchithra Senevirathne, Michael C. Biewer, Steven O. Nielsen, Qian Wang, and Mihaela C. Stefan . A Combined Experimental and Computational Study of the Substituent Effect on Micellar Behavior of γ-Substituted Thermoresponsive Amphiphilic Poly(ε-caprolactone)s. Macromolecules 2013, 46 (12) , 4829-4838.
    23. Abhijeet P. Bapat, Jacob G. Ray, Daniel A. Savin, and Brent S. Sumerlin . Redox-Responsive Dynamic-Covalent Assemblies: Stars and Miktoarm Stars. Macromolecules 2013, 46 (6) , 2188-2198.
    24. Kamal Bauri, Saswati Ghosh Roy, Shashank Pant, and Priyadarsi De . Controlled Synthesis of Amino Acid-Based pH-Responsive Chiral Polymers and Self-Assembly of Their Block Copolymers. Langmuir 2013, 29 (8) , 2764-2774.
    25. Wiriya Thongsomboon, Mark Sherwood, Noel Arellano, and Alshakim Nelson . Thermally Induced Nanoimprinting of Biodegradable Polycarbonates Using Dynamic Covalent Cross-Links. ACS Macro Letters 2013, 2 (1) , 19-22.
    26. Lei You. Dual reactivity based dynamic covalent chemistry: mechanisms and applications. Chemical Communications 2023, 59 (87) , 12943-12958.
    27. Marlena Pięta, Vishal B. Purohit, Joanna Pietrasik, Christopher M. Plummer. Disulfide-containing monomers in chain-growth polymerization. Polymer Chemistry 2022, 14 (1) , 7-31.
    28. Emre Akar, Dilhan Kandemir, Serter Luleburgaz, Volkan Kumbaraci, Hakan Durmaz. Efficient Post-Polymerization modification of pendant aldehyde functional polymer via reductive etherification reaction. European Polymer Journal 2022, 177 , 111440.
    29. Qingsong Xu, Shanlong Li, Meiwei Qi, Jing Gao, Chuanshuang Chen, Pei Huang, Yuling Wang, Chunyang Yu, Wei Huang, Yongfeng Zhou. Membrane‐Bound Inward‐Growth of Artificial Cytoskeletons and Their Selective Disassembly. Angewandte Chemie International Edition 2022, 61 (26)
    30. Qingsong Xu, Shanlong Li, Meiwei Qi, Jing Gao, Chuanshuang Chen, Pei Huang, Yuling Wang, Chunyang Yu, Wei Huang, Yongfeng Zhou. Membrane‐Bound Inward‐Growth of Artificial Cytoskeletons and Their Selective Disassembly. Angewandte Chemie 2022, 134 (26)
    31. Subrata Santra, Soumya Kolay, Sujauddin Sk, Debleena Ghosh, Anmol Mishra, Lisa Roy, Kishor Sarkar, Mijanur Rahaman Molla. Supramolecularly cross-linked nanoassemblies of self-immolative polyurethane from recycled plastic waste: high encapsulation stability and the triggered release of guest molecules. Polymer Chemistry 2022, 13 (22) , 3294-3303.
    32. Thi Nga Tran, Sandie Piogé, Laurent Fontaine, Sagrario Pascual. Synthesis of a dual UCST-type thermosensitive and acid-degradable nanogel based on poly(N-acryloyl glycinamide) and a ketal-containing crosslinker. European Polymer Journal 2022, 173 , 111310.
    33. Hafeezullah Memon, Yi Wei, Chengyan Zhu. Recyclable and reformable epoxy resins based on dynamic covalent bonds – Present, past, and future. Polymer Testing 2022, 105 , 107420.
    34. Yue Liang, Xiao Kuang, Xiaohao Sun, H. Jerry Qi. Recyclable thermoset polymers: beyond self-healing. 2022, 483-511.
    35. Graeme Moad. Trithiocarbonates in RAFT Polymerization. 2021, 359-492.
    36. Catalina Biglione, Thi Mai Phuong Neumann‐Tran, Sidra Kanwal, Daniel Klinger. Amphiphilic micro‐ and nanogels: Combining properties from internal hydrogel networks, solid particles, and micellar aggregates. Journal of Polymer Science 2021, 59 (22) , 2665-2703.
    37. Xiaolei Hu, Arman Moini Jazani, Jung Kwon Oh. Recent advances in development of imine-based acid-degradable polymeric nanoassemblies for intracellular drug delivery. Polymer 2021, 230 , 124024.
    38. Emma E. Brotherton, Craig P. Jesson, Nicholas J. Warren, Mark J. Smallridge, Steven P. Armes. New Aldehyde‐Functional Methacrylic Water‐Soluble Polymers. Angewandte Chemie 2021, 133 (21) , 12139-12144.
    39. Emma E. Brotherton, Craig P. Jesson, Nicholas J. Warren, Mark J. Smallridge, Steven P. Armes. New Aldehyde‐Functional Methacrylic Water‐Soluble Polymers. Angewandte Chemie International Edition 2021, 60 (21) , 12032-12037.
    40. Ismail Altinbasak, Mehmet Arslan, Rana Sanyal, Amitav Sanyal. Pyridyl disulfide-based thiol–disulfide exchange reaction: shaping the design of redox-responsive polymeric materials. Polymer Chemistry 2020, 11 (48) , 7603-7624.
    41. Alexander W. Jackson. Reversible-deactivation radical polymerization of cyclic ketene acetals. Polymer Chemistry 2020, 11 (21) , 3525-3545.
    42. Arman Moini Jazani, Jung Kwon Oh. Development and disassembly of single and multiple acid-cleavable block copolymer nanoassemblies for drug delivery. Polymer Chemistry 2020, 11 (17) , 2934-2954.
    43. Nathan J. Van Zee, Renaud Nicolaÿ. Vitrimers: Permanently crosslinked polymers with dynamic network topology. Progress in Polymer Science 2020, 104 , 101233.
    44. Elena Alexandra Garcia, Diogo Pessoa, Margarita Herrera-Alonso. Oxidative instability of boronic acid-installed polycarbonate nanoparticles. Soft Matter 2020, 16 (10) , 2473-2479.
    45. Alexander W. Jackson, Lohitha Rao Chennamaneni, Praveen Thoniyot. Main-chain degradable, pH-responsive and covalently cross-linked nanoparticles via a one-step RAFT-based radical ring-opening terpolymerization. European Polymer Journal 2020, 122 , 109391.
    46. Binglin Sui, Chen Cheng, Peisheng Xu. Pyridyl Disulfide Functionalized Polymers as Nanotherapeutic Platforms. Advanced Therapeutics 2019, 2 (9)
    47. Zhen Jiang, Ayana Bhaskaran, Heather M. Aitken, India C. G. Shackleford, Luke A. Connal. Using Synergistic Multiple Dynamic Bonds to Construct Polymers with Engineered Properties. Macromolecular Rapid Communications 2019, 40 (10)
    48. Michael E. Bracchi, Gema Dura, David A. Fulton. The synthesis of poly(arylthiols) and their utilization in the preparation of cross-linked dynamic covalent polymer nanoparticles and hydrogels. Polymer Chemistry 2019, 10 (10) , 1258-1267.
    49. James F. Reuther, Samuel D. Dahlhauser, Eric V. Anslyn. Einstellbare orthogonale reversible kovalente Bindungen: dynamische Kontrolle über die molekulare Selbstorganisation. Angewandte Chemie 2019, 131 (1) , 76-88.
    50. James F. Reuther, Samuel D. Dahlhauser, Eric V. Anslyn. Tunable Orthogonal Reversible Covalent (TORC) Bonds: Dynamic Chemical Control over Molecular Assembly. Angewandte Chemie International Edition 2019, 58 (1) , 74-85.
    51. Daniela Pamfil, Cornelia Vasile. Responsive Polymeric Nanotherapeutics. 2019, 67-121.
    52. Wei Liu, Peisen Li, Hongmei Zhang. Preparation of thermosensitive microcapsules and application on the controllable drug delivery of ibuprofen. International Journal of Polymeric Materials and Polymeric Biomaterials 2018, 67 (16) , 978-986.
    53. Raju Bej, Jayita Sarkar, Debes Ray, Vinod K. Aswal, Suhrit Ghosh. Morphology Regulation in Redox Destructible Amphiphilic Block Copolymers and Impact on Intracellular Drug Delivery. Macromolecular Bioscience 2018, 18 (7)
    54. Raju Bej, Jayita Sarkar, Suhrit Ghosh. Structural diversity in poly(disulfide)s. Journal of Polymer Science Part A: Polymer Chemistry 2018, 56 (2) , 194-202.
    55. Soma Mukherjee, Jessica J. Cash, Brent S. Sumerlin. Responsive Dynamic Covalent Polymers. 2017, 321-358.
    56. Sepideh Khoee, Hamed Asadi. Nanogels: Chemical Approaches to Preparation. 2017, 1007-1034.
    57. Aiqing Zhong, Yang Xu, Zidong He, Hui Zhang, Tianqi Wang, Minghong Zhou, Linfeng Xiong, Kun Huang. Thiol‐Functionalized Organic Porous Polymers as a Support for Gold Nanoparticles and Its Catalytic Applications. Macromolecular Chemistry and Physics 2017, 218 (14)
    58. Alexander S. Timin, Albert R. Muslimov, Kirill V. Lepik, Maria V. Okilova, Nikolai Y. Tcvetkov, Alena I. Shakirova, Boris V. Afanasyev, Dmitry A. Gorin, Gleb B. Sukhorukov. Intracellular Breakable and Ultrasound-Responsive Hybrid Microsized Containers for Selective Drug Release into Cancerous Cells. Particle & Particle Systems Characterization 2017, 34 (5) , 1600417.
    59. Weiqiang Zhou, Lu Wang, Feng Li, Weina Zhang, Wei Huang, Fengwei Huo, Huaping Xu. Selenium‐Containing Polymer@Metal‐Organic Frameworks Nanocomposites as an Efficient Multiresponsive Drug Delivery System. Advanced Functional Materials 2017, 27 (6)
    60. Panpan Chen, Yujuan Zhou, Jie Yang. In situ supramolecular polymerization promoted by the marriage of dynamic covalent bonding and pillar[5]arene-based host–guest interaction. Chemical Communications 2017, 53 (6) , 1144-1147.
    61. M. Mario Perera, Neil Ayres. Gelatin based dynamic hydrogels via thiol–norbornene reactions. Polymer Chemistry 2017, 8 (44) , 6741-6749.
    62. Marianne S. Rolph, Maria Inam, Rachel K. O'Reilly. The application of blocked isocyanate chemistry in the development of tunable thermoresponsive crosslinkers. Polymer Chemistry 2017, 8 (46) , 7229-7239.
    63. Tuanwei Liu, Jingjing Hu, Xiaoye Ma, Bing Kong, Jilan Wang, Zhide Zhang, Dian-Shun Guo, Xinlin Yang. Hollow double-layered polymer nanoparticles with S-nitrosothiols for tumor targeted therapy. Journal of Materials Chemistry B 2017, 5 (36) , 7519-7528.
    64. Iordana Neamtu, Alina Gabriela Rusu, Alina Diaconu, Loredana Elena Nita, Aurica P. Chiriac. Basic concepts and recent advances in nanogels as carriers for medical applications. Drug Delivery 2017, 24 (1) , 539-557.
    65. Fátima García, Maarten M. J. Smulders. Dynamic covalent polymers. Journal of Polymer Science Part A: Polymer Chemistry 2016, 54 (22) , 3551-3577.
    66. Sepideh Khoee, Hamed Asadi. Nanogels: Chemical Approaches to Preparation. 2016, 5266-5293.
    67. Rakesh Banerjee, Saikat Maiti, Debabrata Dey, Dibakar Dhara. Polymeric nanostructures with pH-labile core for controlled drug release. Journal of Colloid and Interface Science 2016, 462 , 176-182.
    68. Laura Maggini, Ingrid Cabrera, Amparo Ruiz-Carretero, Eko A. Prasetyanto, Eric Robinet, Luisa De Cola. Breakable mesoporous silica nanoparticles for targeted drug delivery. Nanoscale 2016, 8 (13) , 7240-7247.
    69. Soma Mukherjee, William. L. A. Brooks, Yuqiong Dai, Brent S. Sumerlin. Doubly-dynamic-covalent polymers composed of oxime and oxanorbornene links. Polymer Chemistry 2016, 7 (10) , 1971-1978.
    70. Ye Zhu, Chenglin Yi, Qiong Hu, Wei Wei, Xiaoya Liu. Effect of chain microstructure on self-assembly and emulsification of amphiphilic poly(acrylic acid)-polystyrene copolymers. Physical Chemistry Chemical Physics 2016, 18 (37) , 26236-26244.
    71. Yukako Nakai, Akira Takahashi, Raita Goseki, Hideyuki Otsuka. Facile modification and fixation of diaryl disulphide-containing dynamic covalent polyesters by iodine-catalysed insertion-like addition reactions of styrene derivatives to disulphide units. Polymer Chemistry 2016, 7 (28) , 4661-4666.
    72. Huazhang Guo, Duanguang Yang, Mei Yang, Yong Gao, Yijiang Liu, Huaming Li. Dual responsive Pickering emulsions stabilized by constructed core crosslinked polymer nanoparticles via reversible covalent bonds. Soft Matter 2016, 12 (48) , 9683-9691.
    73. Dipankar Basak, Raju Bej, Suhrit Ghosh. Amphiphilic poly(disulfide) micelles and a remarkable impact of the core hydrophobicity on redox responsive disassembly. Polymer Chemistry 2015, 6 (36) , 6465-6474.
    74. Michael E. Bracchi, David A. Fulton. Orthogonal breaking and forming of dynamic covalent imine and disulfide bonds in aqueous solution. Chemical Communications 2015, 51 (55) , 11052-11055.
    75. Bing Deng, Ping Ma, Yan Xie. Reduction-sensitive polymeric nanocarriers in cancer therapy: a comprehensive review. Nanoscale 2015, 7 (30) , 12773-12795.
    76. Lingzhi Liu, Libin Wu, Junyan Tan, Lin Wang, Qing Liu, Pingwei Liu, Li Liu. “Reduction” responsive thymine-conjugated biodynamers: synthesis and solution properties. Polymer Chemistry 2015, 6 (21) , 3934-3941.
    77. Hui Shi, Kaiyi Zhou, Qiuping Yu, Zhigang Cui, Yanyan Jiang, Xinhua Lu, Yuanli Cai. Programmable self-assembly of a cystamine-block copolymer in response to pH and progressive reduction–ionization–oxidation. Polymer Chemistry 2015, 6 (42) , 7455-7463.
    78. Rakesh Banerjee, Sheetal Parida, Chiranjit Maiti, Mahitosh Mandal, Dibakar Dhara. pH-degradable and thermoresponsive water-soluble core cross-linked polymeric nanoparticles as potential drug delivery vehicle for doxorubicin. RSC Advances 2015, 5 (102) , 83565-83575.
    79. Carina I. C. Crucho. Stimuli‐Responsive Polymeric Nanoparticles for Nanomedicine. ChemMedChem 2015, 10 (1) , 24-38.
    80. Rongrong Li, Fuli Feng, Yinsong Wang, Xiaoying Yang, Xinlin Yang, Victor C. Yang. Folic acid-conjugated pH/temperature/redox multi-stimuli responsive polymer microspheres for delivery of anti-cancer drug. Journal of Colloid and Interface Science 2014, 429 , 34-44.
    81. Nicky Chan, Nathan Yee, So Young An, Jung Kwon Oh. Tuning amphiphilicity/temperature‐induced self‐assembly and in‐situ disulfide crosslinking of reduction‐responsive block copolymers. Journal of Polymer Science Part A: Polymer Chemistry 2014, 52 (14) , 2057-2067.
    82. Zhan Jun Liu, Ming Fei Zhao, Zhen Gang Wu, Gang Han. Synthesis of Allyl-Functionalized Polymers via Selective Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization. Advanced Materials Research 2014, 924 , 65-68.
    83. Yuanpei Li, Kai Xiao, Wei Zhu, Wenbin Deng, Kit S. Lam. Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Advanced Drug Delivery Reviews 2014, 66 , 58-73.
    84. Adam Wilson, Giulio Gasparini, Stefan Matile. Functional systems with orthogonal dynamic covalent bonds. Chem. Soc. Rev. 2014, 43 (6) , 1948-1962.
    85. Rakesh Banerjee, Saikat Maiti, Dibakar Dhara. Synthesis of soluble core cross-linked polystyrene star polymer by application of acrylate-nitrile oxide ‘click chemistry’ using metal-free reagents. Green Chem. 2014, 16 (3) , 1365-1373.
    86. Nicky Chan, So Young An, Jung Kwon Oh. Dual location disulfide degradable interlayer-crosslinked micelles with extended sheddable coronas exhibiting enhanced colloidal stability and rapid release. Polym. Chem. 2014, 5 (5) , 1637-1649.
    87. Kishore Raghupathi, Longyu Li, Judy Ventura, Matthew Jennings, S. Thayumanavan. pH responsive soft nanoclusters with size and charge variation features. Polym. Chem. 2014, 5 (5) , 1737-1742.
    88. Kewei Wang, Hui Peng, Kristofer J. Thurecht, Simon Puttick, Andrew K. Whittaker. Biodegradable core crosslinked star polymer nanoparticles as 19 F MRI contrast agents for selective imaging. Polym. Chem. 2014, 5 (5) , 1760-1771.
    89. Longyu Li, Kishore Raghupathi, Cunfeng Song, Priyaa Prasad, S. Thayumanavan. Self-assembly of random copolymers. Chem. Commun. 2014, 50 (88) , 13417-13432.
    90. Xiaobei Wang, Lin Wang, Shixia Yang, Hanying Zhao, Li Liu. Multi-responsive protein nanocarriers from an anionic dynamic covalent copolymer. Polym. Chem. 2014, 5 (16) , 4797-4804.
    91. Qi Huang, Tao Liu, Chunyan Bao, Qiuning Lin, Meixin Ma, Linyong Zhu. Light and reductive dual stimuli-responsive PEI nanoparticles: “AND” logic response and controllable release. J. Mater. Chem. B 2014, 2 (21) , 3333-3339.
    92. Zhigang Xu, Kelin Zhang, Cuilan Hou, Dongdong Wang, Xiaoyan Liu, Xiujuan Guan, Xiaoyu Zhang, Haixia Zhang. A novel nanoassembled doxorubicin prodrug with a high drug loading for anticancer drug delivery. J. Mater. Chem. B 2014, 2 (22) , 3433-3437.
    93. Zhigang Xu, Dongdong Wang, Shuang Xu, Xiaoyan Liu, Xiaoyu Zhang, Haixia Zhang. Preparation of a Camptothecin Prodrug with Glutathione‐Responsive Disulfide Linker for Anticancer Drug Delivery. Chemistry – An Asian Journal 2014, 9 (1) , 199-205.
    94. Na Re Ko, Kejian Yao, Chuanbing Tang, Jung Kwon Oh. Synthesis and thiol‐responsive degradation of polylactide‐based block copolymers having disulfide junctions using ATRP and ROP. Journal of Polymer Science Part A: Polymer Chemistry 2013, 51 (14) , 3071-3080.
    95. Yi Li, Guang Hui Gao, Doo Sung Lee. Stimulus‐Sensitive Polymeric Nanoparticles and Their Applications as Drug and Gene Carriers. Advanced Healthcare Materials 2013, 2 (3) , 388-417.
    96. Daniel E. Whitaker, Clare S. Mahon, David A. Fulton. Thermoresponsive Dynamic Covalent Single‐Chain Polymer Nanoparticles Reversibly Transform into a Hydrogel. Angewandte Chemie International Edition 2013, 52 (3) , 956-959.
    97. Daniel E. Whitaker, Clare S. Mahon, David A. Fulton. Thermoresponsive Dynamic Covalent Single‐Chain Polymer Nanoparticles Reversibly Transform into a Hydrogel. Angewandte Chemie 2013, 125 (3) , 990-993.
    98. Qian Zhang, Samuel Aleksanian, Seung Man Noh, Jung Kwon Oh. Thiol-responsive block copolymer nanocarriers exhibiting tunable release with morphology changes. Polym. Chem. 2013, 4 (2) , 351-359.
    99. Alexander W. Jackson, David A. Fulton. Making polymeric nanoparticles stimuli-responsive with dynamic covalent bonds. Polym. Chem. 2013, 4 (1) , 31-45.
    100. Xuejun Chen, Na Xu, Nan Li, Lican Lu, Yuanli Cai, Ying Zhao, Dujin Wang. Programmable selectivity of metal–imine bond coordination in subcomponent self-assembly of a primary amine based block copolymer. Soft Matter 2013, 9 (6) , 1885-1894.
    Load all citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect