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Protein Resistance of Surfaces Prepared by Chemisorption of Monothiolated Poly(ethylene glycol) to Gold and Dendronization with Aliphatic Polyester Dendrons: Effect of Hydrophilic Dendrons

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    Protein Resistance of Surfaces Prepared by Chemisorption of Monothiolated Poly(ethylene glycol) to Gold and Dendronization with Aliphatic Polyester Dendrons: Effect of Hydrophilic Dendrons
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    Department of Chemistry and the Brockhouse Institute for Materials Research and Department of Chemical Engineering, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    * Corresponding author: Tel (905) 525-9140 x23514 ; Fax (905) 521-2773; e-mail [email protected]
    †Department of Chemistry and the Brockhouse Institute for Materials Research.
    ‡Department of Chemical Engineering.
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    Macromolecules

    Cite this: Macromolecules 2008, 41, 7, 2567–2576
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    https://doi.org/10.1021/ma702074v
    Published February 28, 2008
    Copyright © 2008 American Chemical Society
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    Abstract

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    Protein adsorption to surfaces prepared by chemisorption of thiol-terminated poly(ethylene glycol) (HS-PEG650-OH) to gold-coated silicon wafers followed by functionalization of the terminal PEG OH groups with aliphatic polyester dendrons was investigated. Chemisorption of HS-PEG650-OH to the gold surfaces was carried out under cloud-point conditions to give a chain density of ∼3.7 chains/nm2, as calculated from AFM film thickness measurements. Dendronization of the PEG-functionalized surfaces with aliphatic polyester dendrons, generations 1−4, was achieved using divergent dendron growth. The hydrophilicity of the surfaces increased significantly with increasing dendron generation as shown by water contact angle data. The effect of the hydrophilic dendrons on protein adsorption from phosphate-buffered saline (PBS) and plasma are reported. Adsorption of both 125I-radiolabled fibrinogen and lysozyme onto the dendronized surfaces showed that protein adsorption increases upon introduction of dendrons to the PEG-functionalized surfaces. The similarity between fibrinogen and lysozyme adsorption suggests that resistance of the dendronized surfaces to proteins follows the same trend regardless of protein size.

    Copyright © 2008 American Chemical Society

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    High-resolution XPS data, AFM monolayer height analysis, and full TOF-SIMS spectra. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Macromolecules

    Cite this: Macromolecules 2008, 41, 7, 2567–2576
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ma702074v
    Published February 28, 2008
    Copyright © 2008 American Chemical Society
    Request reuse permissions

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