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Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe

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Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands, Debye Institute, Condensed Matter and Interfaces, Utrecht University, P.O. Box 80.000, 3508 TA Utrecht, The Netherlands, Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology/Internal Medicine, Maastricht University & University Hospital, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands, Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), 3508 TB, Utrecht, The Netherlands, and Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
Cite this: Nano Lett. 2006, 6, 1, 1–6
Publication Date (Web):November 24, 2005
https://doi.org/10.1021/nl051935m
Copyright © 2006 American Chemical Society

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    Abstract

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    MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r1, of nearly 2000 mM-1s-1 per quantum dot. The quantum dots were functionalized by covalently linking αvβ3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.

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     Corresponding author. E-mail:  [email protected]. Phone:  +31 40 2474853. Fax:  +31 40 2432598.

     Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology.

     Debye Institute, Condensed Matter and Interfaces, Utrecht University.

    §

     Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology/Internal Medicine, Maastricht University & University Hospital.

     Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS).

     Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology.

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    Materials, descriptions of the synthesis of CdSe/ZnS core/shell quantum dots, and the emission and absorption spectrum of quantum dots in chloroform. This material is available free of charge via the Internet at http://pubs.acs.org.

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