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Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects

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Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University School of Medicine, 1201 Welch Road, Stanford, California 94305, Department of Materials Science and Engineering, Stanford University, 476 Lomita Mall, Stanford, California 94305, and Department of Bioengineering, Stanford University School of Medicine, Stanford, California 94305
Cite this: Nano Lett. 2006, 6, 4, 669–676
Publication Date (Web):March 11, 2006
https://doi.org/10.1021/nl052405t
Copyright © 2006 American Chemical Society

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    We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

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     Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University School of Medicine.

     Department of Materials Science and Engineering, Stanford University.

    §

     Department of Bioengineering, Stanford University School of Medicine.

    *

     Corresponding author. Phone:  650-725-0950. Fax:  650-736-7925. E-mail:  [email protected].

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    Cell-staining experiments and the autofluorescence and QD spectra used for spectral unmixing. This material is available free of charge via the Internet at http://pubs.acs.org.

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