Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living SubjectsClick to copy article linkArticle link copied!
Abstract

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
†
Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University School of Medicine.
‡
Department of Materials Science and Engineering, Stanford University.
§
Department of Bioengineering, Stanford University School of Medicine.
*
Corresponding author. Phone: 650-725-0950. Fax: 650-736-7925. E-mail: [email protected].
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