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Nanocomposite Gold-Silk Nanofibers

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David H. Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, United States
§ Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
Department of Physics, Dana Research Center, Northeastern University, Boston, Massachusetts 02115, United States
School of Engineering and Applied Science and #Center for Nanoscale Systems, Harvard University, Cambridge, Massachusetts 02138, United States
Cite this: Nano Lett. 2012, 12, 10, 5403–5406
Publication Date (Web):August 28, 2012
https://doi.org/10.1021/nl302810c
Copyright © 2012 American Chemical Society
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Abstract

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Cell-biomaterial interactions can be controlled by modifying the surface chemistry or nanotopography of the material, to induce cell proliferation and differentiation if desired. Here we combine both approaches in forming silk nanofibers (SNFs) containing gold nanoparticles (AuNPs) and subsequently chemically modifying the fibers. Silk fibroin mixed with gold seed nanoparticles was electrospun to form SNFs doped with gold seed nanoparticles (SNFseed). Following gold reduction, there was a 2-fold increase in particle diameter confirmed by the appearance of a strong absorption peak at 525 nm. AuNPs were dispersed throughout the AuNP-doped silk nanofibers (SNFsAu). The Young’s modulus of the SNFsAu was almost 70% higher than that of SNFs. SNFsAu were modified with the arginine-glycine-aspartic acid (RGD) peptide. Human mesenchymal stem cells that were cultured on RGD-modified SNFAu had a more than 2-fold larger cell area compared to the cells cultured on bare SNFs; SNFAu also increased cell size. This approach may be used to alter the cell–material interface in tissue engineering and other applications.

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