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Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2013, 13, 4, 1489-1494
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    A Highly Specific Gold Nanoprobe for Live-Cell Single-Molecule Imaging
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    † LP2N, Université de Bordeaux, Institut d’Optique & CNRS UMR 5298, F- 33405 Talence, France
    ‡ Laboratoire d’Enzymologie et Biochimie Structurales UPR3082, CNRS, F-91198 Gif-sur-Yvette France
    § Department of Cell Physiology and Metabolism, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland
    ∥ Université de Bordeaux, IINS UMR 5297, CNRS, F-33000 Bordeaux, France
    *E-mail: [email protected]
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    Nano Letters

    Cite this: Nano Lett. 2013, 13, 4, 1489–1494
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    https://doi.org/10.1021/nl304561g
    Published March 4, 2013
    Copyright © 2013 American Chemical Society
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    Abstract

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    Single molecule tracking in live cells is the ultimate tool to study subcellular protein dynamics, but it is often limited by the probe size and photostability. Because of these issues, long-term tracking of proteins in confined and crowded environments, such as intracellular spaces, remains challenging. We have developed a novel optical probe consisting of 5 nm gold nanoparticles functionalized with a small fragment of camelid antibodies that recognize widely used green fluorescent proteins (GFPs) with a very high affinity, which we call GFP-nanobodies. These small gold nanoparticles can be detected and tracked using photothermal imaging for arbitrarily long periods of time. Surface and intracellular GFP-proteins were effectively labeled even in very crowded environments such as adhesion sites and cytoskeletal structures both in vitro and in live cell cultures. These nanobody-coated gold nanoparticles are probes with unparalleled capabilities; small size, perfect photostability, high specificity, and versatility afforded by combination with the vast existing library of GFP-tagged proteins.

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    5. Priscilla Choo, Alexander J. Hryn, Kayla S. Culver, Debanjan Bhowmik, Jingtian Hu, Teri W. Odom. Wavelength-Dependent Differential Interference Contrast Inversion of Anisotropic Gold Nanoparticles. The Journal of Physical Chemistry C 2018, 122 (47) , 27024-27031. https://doi.org/10.1021/acs.jpcc.8b08995
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    7. Elissa M. Grzincic and Catherine J. Murphy . Gold Nanorods Indirectly Promote Migration of Metastatic Human Breast Cancer Cells in Three-Dimensional Cultures. ACS Nano 2015, 9 (7) , 6801-6816. https://doi.org/10.1021/acsnano.5b03362
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    9. Eunkeu Oh, Kimihiro Susumu, Antti J. Mäkinen, Jeffrey R. Deschamps, Alan L. Huston, and Igor L. Medintz . Colloidal Stability of Gold Nanoparticles Coated with Multithiol-Poly(ethylene glycol) Ligands: Importance of Structural Constraints of the Sulfur Anchoring Groups. The Journal of Physical Chemistry C 2013, 117 (37) , 18947-18956. https://doi.org/10.1021/jp405265u
    10. Lei Yan, Zongguang Liu, Junzhuan Wang, Linwei Yu. Integrating Hard Silicon for High-Performance Soft Electronics via Geometry Engineering. Nano-Micro Letters 2025, 17 (1) https://doi.org/10.1007/s40820-025-01724-1
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    12. Shenglan Zhang, Jieyao Ma, Liu He, Qianying Li, Pan He, Jing Li, Huicong Zhang. Generation and characterization of nanobodies targeting human pepsinogens. Protein Expression and Purification 2024, 216 , 106431. https://doi.org/10.1016/j.pep.2024.106431
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    15. Ruifang Su, Yu‐Tang Wu, Sofia Doulkeridou, Xue Qiu, Thomas Just Sørensen, Kimihiro Susumu, Igor L. Medintz, Paul M. P. van Bergen en Henegouwen, Niko Hildebrandt. A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR). Angewandte Chemie 2022, 134 (33) https://doi.org/10.1002/ange.202207797
    16. Ruifang Su, Yu‐Tang Wu, Sofia Doulkeridou, Xue Qiu, Thomas Just Sørensen, Kimihiro Susumu, Igor L. Medintz, Paul M. P. van Bergen en Henegouwen, Niko Hildebrandt. A Nanobody‐on‐Quantum Dot Displacement Assay for Rapid and Sensitive Quantification of the Epidermal Growth Factor Receptor (EGFR). Angewandte Chemie International Edition 2022, 61 (33) https://doi.org/10.1002/anie.202207797
    17. Subhasis Adhikari, Michel Orrit. Single-molecule and -particle spectroscopy in Leiden: absorption, scattering and fluorescence. Journal of Optics 2022, 24 (4) , 043001. https://doi.org/10.1088/2040-8986/ac51b2
    18. Maryam Zain, Humaira Yasmeen, Sunishtha S. Yadav, Sidra Amir, Muhammad Bilal, Aqsa Shahid, Mohsin Khurshid. Applications of nanotechnology in biological systems and medicine. 2022, 215-235. https://doi.org/10.1016/B978-0-12-823971-1.00019-2
    19. Yonghui Wang, Fei Wang, Junyan Liu, Mingjun Chen, Yang Wang. Simulations and Experimental Study of Individual Au Nanoparticle Using Photothermal Heterodyne Imaging (PHI). IEEE Transactions on Instrumentation and Measurement 2022, 71 , 1-6. https://doi.org/10.1109/TIM.2021.3138090
    20. Nadja Groysbeck, Mariel Donzeau, Audrey Stoessel, Anne-Marie Haeberle, Stéphane Ory, Danièle Spehner, Patrick Schultz, Ovidiu Ersen, Mounib Bahri, Dris Ihiawakrim, Guy Zuber. Gold labelling of a green fluorescent protein (GFP)-tag inside cells using recombinant nanobodies conjugated to 2.4 nm thiolate-coated gold nanoparticles. Nanoscale Advances 2021, 3 (24) , 6940-6948. https://doi.org/10.1039/D1NA00256B
    21. Thomas Orré, Adrien Joly, Zeynep Karatas, Birgit Kastberger, Clément Cabriel, Ralph T. Böttcher, Sandrine Lévêque-Fort, Jean-Baptiste Sibarita, Reinhard Fässler, Bernhard Wehrle-Haller, Olivier Rossier, Grégory Giannone. Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions. Nature Communications 2021, 12 (1) https://doi.org/10.1038/s41467-021-23372-w
    22. Guangfa Bao, Ming Tang, Jun Zhao, Xiaohua Zhu. Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Research 2021, 11 (1) https://doi.org/10.1186/s13550-021-00750-5
    23. Amine Mehidi, Frieda Kage, Zeynep Karatas, Maureen Cercy, Matthias Schaks, Anna Polesskaya, Matthieu Sainlos, Alexis M. Gautreau, Olivier Rossier, Klemens Rottner, Grégory Giannone. Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration. Nature Cell Biology 2021, 23 (11) , 1148-1162. https://doi.org/10.1038/s41556-021-00786-8
    24. Jing Chen, Van Phuc Nguyen, Sangeeta Jaiswal, Xiaoyu Kang, Miki Lee, Yannis M. Paulus, Thomas D. Wang. Thin Layer-Protected Gold Nanoparticles for Targeted Multimodal Imaging with Photoacoustic and CT. Pharmaceuticals 2021, 14 (11) , 1075. https://doi.org/10.3390/ph14111075
    25. Jung-Dae Kim, Dong Uk Kim, Chan Bae Jeong, Ilkyu Han, Ji Yong Bae, Hwan Hur, Ki-Hwan Nam, Sangwon Hyun, I Jong Kim, Kye-Sung Lee, Ki Soo Chang. Wide-field photothermal reflectance spectroscopy for single nanoparticle absorption spectrum analysis. Nanophotonics 2021, 10 (13) , 3433-3440. https://doi.org/10.1515/nanoph-2021-0203
    26. Zhao Wang, Xuejing Wang, Ying Zhang, Weili Xu, Xiaojun Han. Principles and Applications of Single Particle Tracking in Cell Research. Small 2021, 17 (11) https://doi.org/10.1002/smll.202005133
    27. Prachi Bhol, Madhuchhanda Mohanty, Priti S. Mohanty. Polymer-matrix stabilized metal nanoparticles: Synthesis, characterizations and insight into molecular interactions between metal ions, atoms and polymer moieties. Journal of Molecular Liquids 2021, 325 , 115135. https://doi.org/10.1016/j.molliq.2020.115135
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    31. Smith Sagar Satapathy, Satyabrata Si. One-step chemical synthesis of Ag–Au alloy nanoparticles for modulating the catalytic hydrogenation reaction. Applied Nanoscience 2020, 10 (11) , 4139-4148. https://doi.org/10.1007/s13204-020-01523-7
    32. Man-Jyun Wu, Wei-Lung Tseng. Rapid, facile, reagentless, and room-temperature conjugation of monolayer MoS 2 nanosheets with dual-fluorophore-labeled flares as nanoprobes for ratiometric sensing of TK1 mRNA in living cells. Journal of Materials Chemistry B 2020, 8 (8) , 1692-1698. https://doi.org/10.1039/C9TB02770J
    33. Jaehwan Hong, Dae Kun Hwang, Chulhwan Park, Younghun Kim. Photothermal performance of plasmonic patch with gold nanoparticles embedded on polymer matrix. Korean Journal of Chemical Engineering 2019, 36 (10) , 1746-1751. https://doi.org/10.1007/s11814-019-0361-4
    34. Johan Elf, Irmeli Barkefors. Single-Molecule Kinetics in Living Cells. Annual Review of Biochemistry 2019, 88 (1) , 635-659. https://doi.org/10.1146/annurev-biochem-013118-110801
    35. Thomas Orré, Olivier Rossier, Grégory Giannone. The inner life of integrin adhesion sites: From single molecules to functional macromolecular complexes. Experimental Cell Research 2019, 379 (2) , 235-244. https://doi.org/10.1016/j.yexcr.2019.03.036
    36. Depeng Wang, Jun Xia. Optics based biomedical imaging: Principles and applications. Journal of Applied Physics 2019, 125 (19) https://doi.org/10.1063/1.5088490
    37. Martinho Soto-Ribeiro, Birgit Kastberger, Michael Bachmann, Latifeh Azizi, Kenza Fouad, Marie-Claude Jacquier, David Boettiger, Daniel Bouvard, Martin Bastmeyer, Vesa P. Hytönen, Bernhard Wehrle-Haller. β1D integrin splice variant stabilizes integrin dynamics and reduces integrin signaling by limiting paxillin recruitment. Journal of Cell Science 2019, 132 (8) https://doi.org/10.1242/jcs.224493
    38. Richard De Mets, Irene Wang, Martial Balland, Christiane Oddou, Philippe Moreau, Bertrand Fourcade, Corinne Albiges-Rizo, Antoine Delon, Olivier Destaing, . Cellular tension encodes local Src-dependent differential β 1 and β 3 integrin mobility. Molecular Biology of the Cell 2019, 30 (2) , 181-190. https://doi.org/10.1091/mbc.E18-04-0253
    39. Vesna V. Vodnik, Una Bogdanović. Metal nanoparticles and their composites: a promising multifunctional nanomaterial for biomedical and related applications. 2019, 397-426. https://doi.org/10.1016/B978-0-08-102814-8.00014-7
    40. Jun Miyazaki, Yasunobu Toumon. Experimental evaluation of temperature increase and associated detection sensitivity in shot noise-limited photothermal microscopy. Optics Communications 2019, 430 , 170-175. https://doi.org/10.1016/j.optcom.2018.08.007
    41. Ankita Bachhawat Jaykumar, Paulo S. Caceres, Pablo A. Ortiz. Single-molecule labeling for studying trafficking of renal transporters. American Journal of Physiology-Renal Physiology 2018, 315 (5) , F1243-F1249. https://doi.org/10.1152/ajprenal.00082.2017
    42. Mohamed A. Aly, Konrad J. Domig, Wolfgang Kneifel, Erik Reimhult. Immunogold Nanoparticles for Rapid Plasmonic Detection of C. sakazakii. Sensors 2018, 18 (7) , 2028. https://doi.org/10.3390/s18072028
    43. Ester Polo, María F. Navarro Poupard, Luca Guerrini, Pablo Taboada, Beatriz Pelaz, Ramón A. Alvarez-Puebla, Pablo del Pino. Colloidal bioplasmonics. Nano Today 2018, 20 , 58-73. https://doi.org/10.1016/j.nantod.2018.04.003
    44. Dayong Jin, Peng Xi, Baoming Wang, Le Zhang, Jörg Enderlein, Antoine M. van Oijen. Nanoparticles for super-resolution microscopy and single-molecule tracking. Nature Methods 2018, 15 (6) , 415-423. https://doi.org/10.1038/s41592-018-0012-4
    45. Taka A. Tsunoyama, Yusuke Watanabe, Junri Goto, Kazuma Naito, Rinshi S. Kasai, Kenichi G. N. Suzuki, Takahiro K. Fujiwara, Akihiro Kusumi. Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function. Nature Chemical Biology 2018, 14 (5) , 497-506. https://doi.org/10.1038/s41589-018-0032-5
    46. Takayoshi Kobayashi, Koshi Kawasumi, Jun Miyazaki, Kazuaki Nakata. Resolution enhancement of pump–probe microscope with an inverse-annular filter. Optical Review 2018, 25 (2) , 271-294. https://doi.org/10.1007/s10043-018-0416-5
    47. Dominik Schumacher, Jonas Helma, Anselm F. L. Schneider, Heinrich Leonhardt, Christian P. R. Hackenberger. Nanobodys: Strategien zur chemischen Funktionalisierung und intrazelluläre Anwendungen. Angewandte Chemie 2018, 130 (9) , 2336-2357. https://doi.org/10.1002/ange.201708459
    48. Dominik Schumacher, Jonas Helma, Anselm F. L. Schneider, Heinrich Leonhardt, Christian P. R. Hackenberger. Nanobodies: Chemical Functionalization Strategies and Intracellular Applications. Angewandte Chemie International Edition 2018, 57 (9) , 2314-2333. https://doi.org/10.1002/anie.201708459
    49. Thomas Orré, Amine Mehidi, Sophie Massou, Olivier Rossier, Grégory Giannone. Using Single-Protein Tracking to Study Cell Migration. 2018, 291-311. https://doi.org/10.1007/978-1-4939-7701-7_21
    50. Linglu Yi, Jin-Ming Lin. Cell Culture and Observation on Microfluidics. 2018, 119-147. https://doi.org/10.1007/978-981-10-5394-8_4
    51. Lu An, Yuanyuan Wang, Qiwei Tian, Shiping Yang. Small Gold Nanorods: Recent Advances in Synthesis, Biological Imaging, and Cancer Therapy. Materials 2017, 10 (12) , 1372. https://doi.org/10.3390/ma10121372
    52. Smith Sagar Satapathy, Prachi Bhol, Aswathy Chakkarambath, Jagdeep Mohanta, Kunal Samantaray, Suresh K. Bhat, Subhendu K. Panda, Priti S. Mohanty, Satyabrata Si. Thermo-responsive PNIPAM-metal hybrids: An efficient nanocatalyst for the reduction of 4-nitrophenol. Applied Surface Science 2017, 420 , 753-763. https://doi.org/10.1016/j.apsusc.2017.05.172
    53. Peiyuan Kang, Zhuo Chen, Steven O. Nielsen, Kenneth Hoyt, Sheena D'Arcy, Jeremiah J. Gassensmith, Zhenpeng Qin. Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating. Small 2017, 13 (36) https://doi.org/10.1002/smll.201700841
    54. Jun Miyazaki, Takayoshi Kobayahsi. Photothermal Microscopy for High Sensitivity and High Resolution Absorption Contrast Imaging of Biological Tissues. Photonics 2017, 4 (2) , 32. https://doi.org/10.3390/photonics4020032
    55. Satyabrata Si, Arttatrana Pal, Jagdeep Mohanta, Smith Sagar Satapathy. Gold nanostructure materials in diabetes management. Journal of Physics D: Applied Physics 2017, 50 (13) , 134003. https://doi.org/10.1088/1361-6463/aa5e21
    56. Gustavo Bodelón, Celina Costas, Jorge Pérez-Juste, Isabel Pastoriza-Santos, Luis M. Liz-Marzán. Gold nanoparticles for regulation of cell function and behavior. Nano Today 2017, 13 , 40-60. https://doi.org/10.1016/j.nantod.2016.12.014
    57. Edakkattuparambil Sidharth Shibu, Nadezda Varkentina, Laurent Cognet, Brahim Lounis. Small Gold Nanorods with Tunable Absorption for Photothermal Microscopy in Cells. Advanced Science 2017, 4 (2) https://doi.org/10.1002/advs.201600280
    58. S.H. Crayton, A.K. Chen, J.F. Liu, E.M. Higbee-Dempsey, C.-H. Huang, A. Tsourkas, Z. Cheng. 3.20 Molecular Imaging ☆. 2017, 424-466. https://doi.org/10.1016/B978-0-12-803581-8.10222-X
    59. Julie Russier, Laura Oudjedi, Martin Piponnier, Cyrill Bussy, Maurizio Prato, Kostas Kostarelos, Brahim Lounis, Alberto Bianco, Laurent Cognet. Direct visualization of carbon nanotube degradation in primary cells by photothermal imaging. Nanoscale 2017, 9 (14) , 4642-4645. https://doi.org/10.1039/C6NR09795B
    60. Dominik Schumacher, Oliver Lemke, Jonas Helma, Lena Gerszonowicz, Verena Waller, Tina Stoschek, Patrick M. Durkin, Nediljko Budisa, Heinrich Leonhardt, Bettina G. Keller, Christian P. R. Hackenberger. Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling. Chemical Science 2017, 8 (5) , 3471-3478. https://doi.org/10.1039/C7SC00574A
    61. Mi Li, Dan Dang, Lianqing Liu, Ning Xi, Yuechao Wang. Imaging and Force Recognition of Single Molecular Behaviors Using Atomic Force Microscopy. Sensors 2017, 17 (1) , 200. https://doi.org/10.3390/s17010200
    62. Bedia Begüm Karakoçak, Ramesh Raliya, Josh T. Davis, Sanmathi Chavalmane, Wei-Ning Wang, Nathan Ravi, Pratim Biswas. Biocompatibility of gold nanoparticles in retinal pigment epithelial cell line. Toxicology in Vitro 2016, 37 , 61-69. https://doi.org/10.1016/j.tiv.2016.08.013
    63. Smithsagar Satapathy, Jagdeep Mohanta, Satyabrata Si. Modulating the Catalytic Activity of Gold Nanoparticles through Surface Tailoring. ChemistrySelect 2016, 1 (15) , 4940-4948. https://doi.org/10.1002/slct.201600985
    64. Amit K. Bhunia , Tapanendu Kamilya, Satyajit Saha. Temperature Dependent and Kinetic Study of the Adsorption of Bovine Serum Albumin to ZnO Nanoparticle Surfaces. ChemistrySelect 2016, 1 (11) , 2872-2882. https://doi.org/10.1002/slct.201600446
    65. Mingqiang Liu, Mladen Franko. Thermal Lens Spectrometry: Still a Technique on the Horizon?. International Journal of Thermophysics 2016, 37 (7) https://doi.org/10.1007/s10765-016-2072-y
    66. Jun Miyazaki, Tadatsune Iida, Shinji Tanaka, Akiko Hayashi-Takagi, Haruo Kasai, Shigeo Okabe, Takayoshi Kobayashi. Fast 3D visualization of endogenous brain signals with high-sensitivity laser scanning photothermal microscopy. Biomedical Optics Express 2016, 7 (5) , 1702. https://doi.org/10.1364/BOE.7.001702
    67. , , , Daeha Seo, Hyunjung Lee, Jung-uk Lee, Thomas J. Haas, Young-wook Jun. Monovalent plasmonic nanoparticles for biological applications. 2016, 97220I. https://doi.org/10.1117/12.2208635
    68. Olivier Rossier, Grégory Giannone. The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking. Experimental Cell Research 2016, 343 (1) , 28-34. https://doi.org/10.1016/j.yexcr.2015.11.004
    69. Jagdeep Mohanta, Smithsagar Satapathy, Satyabrata Si. Porous Silica‐Coated Gold Nanorods: A Highly Active Catalyst for the Reduction of 4‐Nitrophenol. ChemPhysChem 2016, 17 (3) , 364-368. https://doi.org/10.1002/cphc.201501127
    70. Carlo Manzo, Maria F Garcia-Parajo. A review of progress in single particle tracking: from methods to biophysical insights. Reports on Progress in Physics 2015, 78 (12) , 124601. https://doi.org/10.1088/0034-4885/78/12/124601
    71. Lauren A. Austin, Bin Kang, Mostafa A. El-Sayed. Probing molecular cell event dynamics at the single-cell level with targeted plasmonic gold nanoparticles: A review. Nano Today 2015, 10 (5) , 542-558. https://doi.org/10.1016/j.nantod.2015.07.005
    72. Mary Sajini Devadas, Tuphan Devkota, Paul Johns, Zhongming Li, Shun Shang Lo, Kuai Yu, Libai Huang, Gregory V Hartland. Imaging nano-objects by linear and nonlinear optical absorption microscopies. Nanotechnology 2015, 26 (35) , 354001. https://doi.org/10.1088/0957-4484/26/35/354001
    73. Jun Miyazaki, Hiromichi Tsurui, Takayoshi Kobayashi. Reduction of distortion in photothermal microscopy and its application to the high-resolution three-dimensional imaging of nonfluorescent tissues. Biomedical Optics Express 2015, 6 (9) , 3217. https://doi.org/10.1364/BOE.6.003217
    74. Amit Kumar Bhunia, Pijus Kanti Samanta, Debasish Aich, Satyajit Saha, Tapanendu Kamilya. Biocompatibility study of protein capped and uncapped silver nanoparticles on human hemoglobin. Journal of Physics D: Applied Physics 2015, 48 (23) , 235305. https://doi.org/10.1088/0022-3727/48/23/235305
    75. Jonas Helma, M. Cristina Cardoso, Serge Muyldermans, Heinrich Leonhardt. Nanobodies and recombinant binders in cell biology. Journal of Cell Biology 2015, 209 (5) , 633-644. https://doi.org/10.1083/jcb.201409074
    76. D. J. Nieves, Y. Li, D. G. Fernig, R. Lévy. Photothermal raster image correlation spectroscopy of gold nanoparticles in solution and on live cells. Royal Society Open Science 2015, 2 (6) , 140454. https://doi.org/10.1098/rsos.140454
    77. David Paramelle, Daniel Nieves, Benjamin Brun, Rachel S. Kraut, David G. Fernig. Targeting Cell Membrane Lipid Rafts by Stoichiometric Functionalization of Gold Nanoparticles with a Sphingolipid‐Binding Domain Peptide. Advanced Healthcare Materials 2015, 4 (6) , 911-917. https://doi.org/10.1002/adhm.201400730
    78. Kamalesh Chaudhari, Thalappil Pradeep. In vitro colocalization of plasmonic nano-biolabels and biomolecules using plasmonic and Raman scattering microspectroscopy. Journal of Biomedical Optics 2015, 20 (04) , 1. https://doi.org/10.1117/1.JBO.20.4.046011
    79. Jun Miyazaki, Hiromichi Tsurui, Koshi Kawasumi, Takayoshi Kobayashi. Sensitivity enhancement of photothermal microscopy with radially segmented balanced detection. Optics Letters 2015, 40 (4) , 479. https://doi.org/10.1364/OL.40.000479
    80. Jun Miyazaki, Hiromichi Tsurui, Koshi Kawasumi, Takayoshi Kobayashi. Simultaneous dual-wavelength imaging of nonfluorescent tissues with 3D subdiffraction photothermal microscopy. Optics Express 2015, 23 (3) , 3647. https://doi.org/10.1364/OE.23.003647
    81. Cécile Leduc, Satyabrata Si, Jérémie J. Gautier, Zhenghong Gao, Edakkattuparambil S. Shibu, Alexis Gautreau, Grégory Giannone, Laurent Cognet, Brahim Lounis. Single-molecule imaging in live cell using gold nanoparticles. 2015, 13-27. https://doi.org/10.1016/bs.mcb.2014.10.002
    82. Sawako Yamashiro, Hiroaki Mizuno, Naoki Watanabe. An easy-to-use single-molecule speckle microscopy enabling nanometer-scale flow and wide-range lifetime measurement of cellular actin filaments. 2015, 43-59. https://doi.org/10.1016/bs.mcb.2014.10.013
    83. André Heber, Markus Selmke, Frank Cichos. Thermal diffusivity measured using a single plasmonic nanoparticle. Physical Chemistry Chemical Physics 2015, 17 (32) , 20868-20872. https://doi.org/10.1039/C5CP02920A
    84. Jinbao Qin, Zhiyou Peng, Bo Li, Kaichuang Ye, Yuxin Zhang, Fukang Yuan, Xinrui Yang, Lijia Huang, Junqing Hu, Xinwu Lu. Gold nanorods as a theranostic platform for in vitro and in vivo imaging and photothermal therapy of inflammatory macrophages. Nanoscale 2015, 7 (33) , 13991-14001. https://doi.org/10.1039/C5NR02521D
    85. Lionel Maurizi, Alexis Claveau, Heinrich Hofmann, . Polymer Adsorption on Iron Oxide Nanoparticles for One‐Step Amino‐Functionalized Silica Encapsulation. Journal of Nanomaterials 2015, 2015 (1) https://doi.org/10.1155/2015/732719
    86. Shuiping Liu, Lianjiang Tan, Xiaoqiang Li, Jiajia Fu, Ioannis S. Chronakis, Mingqiao Ge. Gold nanoparticles–gelatin hybrid fibers with bright photoluminescence. Materials Letters 2014, 135 , 1-4. https://doi.org/10.1016/j.matlet.2014.07.070
    87. Loredana Latterini, Luigi Tarpani. Photothermal Effect of Gold Nanostructures for Application in Bioimaging and Therapy. 2014, 173-200. https://doi.org/10.1002/9783527675821.ch07
    88. Jun Miyazaki, Hiromichi Tsurui, Koshi Kawasumi, Takayoshi Kobayashi. Optimal detection angle in sub-diffraction resolution photothermal microscopy: application for high sensitivity imaging of biological tissues. Optics Express 2014, 22 (16) , 18833. https://doi.org/10.1364/OE.22.018833
    89. Bin-Bing Wang, Jun Zhou, Hao-Peng Zhang, Jin-Ping Chen. Fano-like resonance characteristics of asymmetric Fe 2 O 3 @Au core/shell nanorice dimer. Chinese Physics B 2014, 23 (8) , 087303. https://doi.org/10.1088/1674-1056/23/8/087303
    90. Markus Selmke, André Heber, Marco Braun, Frank Cichos. Photothermal single particle microscopy using a single laser beam. Applied Physics Letters 2014, 105 (1) https://doi.org/10.1063/1.4890104
    91. Laurent Cognet, Cécile Leduc, Brahim Lounis. Advances in live-cell single-particle tracking and dynamic super-resolution imaging. Current Opinion in Chemical Biology 2014, 20 , 78-85. https://doi.org/10.1016/j.cbpa.2014.04.015
    92. PIERRE VERMEULEN, LAURENT COGNET, BRAHIM LOUNIS. Photothermal microscopy: optical detection of small absorbers in scattering environments. Journal of Microscopy 2014, 254 (3) , 115-121. https://doi.org/10.1111/jmi.12130
    93. Thomas De Meyer, Serge Muyldermans, Ann Depicker. Nanobody-based products as research and diagnostic tools. Trends in Biotechnology 2014, 32 (5) , 263-270. https://doi.org/10.1016/j.tibtech.2014.03.001
    94. Linyi Bai, Liangliang Zhu, Chung Yen Ang, Xin Li, Shaojue Wu, Yongfei Zeng, Hans Ågren, Yanli Zhao. Iron(III)‐Quantity‐Dependent Aggregation–Dispersion Conversion of Functionalized Gold Nanoparticles. Chemistry – A European Journal 2014, 20 (14) , 4032-4037. https://doi.org/10.1002/chem.201303958
    95. Na Li, Pengxiang Zhao, Didier Astruc. Anisotrope Gold‐Nanopartikel: Synthese, Eigenschaften, Anwendungen und Toxizität. Angewandte Chemie 2014, 126 (7) , 1784-1818. https://doi.org/10.1002/ange.201300441
    96. Na Li, Pengxiang Zhao, Didier Astruc. Anisotropic Gold Nanoparticles: Synthesis, Properties, Applications, and Toxicity. Angewandte Chemie International Edition 2014, 53 (7) , 1756-1789. https://doi.org/10.1002/anie.201300441
    97. Thomas De Meyer, Dominique Eeckhout, Riet De Rycke, Sylvie De Buck, Serge Muyldermans, Ann Depicker. Generation of VHH antibodies against the Arabidopsis thaliana seed storage proteins. Plant Molecular Biology 2014, 84 (1-2) , 83-93. https://doi.org/10.1007/s11103-013-0118-0
    98. Lionel Maurizi, Usawadee Sakulkhu, Lindsey A. Crowe, Vanessa Mai Dao, Nicolas Leclaire, Jean-Paul Vallée, Heinrich Hofmann. Syntheses of cross-linked polymeric superparamagnetic beads with tunable properties. RSC Adv. 2014, 4 (22) , 11142-11146. https://doi.org/10.1039/C3RA48004F
    99. D. J. Nieves, N. S. Azmi, R. Xu, R. Lévy, E. A. Yates, D. G. Fernig. Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry. Chem. Commun. 2014, 50 (86) , 13157-13160. https://doi.org/10.1039/C4CC05909C
    100. Shasha Yao, Yu Zhang, Junli Zhang, Xu Zhang, Binjie Li, Yanbao Zhao. Multifunctional hydroxyapatite nanoparticle-based affinity adsorbent with sensing and fluorescence imaging capacity. J. Mater. Chem. B 2014, 2 (45) , 7988-7995. https://doi.org/10.1039/C4TB01075B
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    Cite this: Nano Lett. 2013, 13, 4, 1489–1494
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    https://doi.org/10.1021/nl304561g
    Published March 4, 2013
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