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Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine

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Department of Materials Science & Engineering, Cornell University, Ithaca, New York 14853, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, and Hybrid Silica Technologies, Ithaca, New York 14850
* Corresponding authors. U.W. mailing address: Department of Materials Science & Engineering, Cornell University, 214 Bard Hall, Ithaca, NY 14853. Phone: (607)-255-3487. Fax: (607) 255-2365. E-mail: [email protected]. M.B. mailing address: Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10065. Phone (212)-639-8938. E-mail: [email protected]
†Department of Materials Science & Engineering, Cornell University.
‡Memorial Sloan-Kettering Cancer Center.
§Hybrid Silica Technologies.
Cite this: Nano Lett. 2009, 9, 1, 442–448
Publication Date (Web):December 19, 2008
https://doi.org/10.1021/nl803405h
Copyright © 2008 American Chemical Society
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Abstract

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The development of molecularly targeted probes that exhibit high biostability, biocompatibility, and efficient clearance profiles is key to optimizing biodistribution and transport across biological barriers. Further, coupling probes designed to meet these criteria with high-sensitivity, quantitative imaging strategies is mandatory for ensuring early in vivo tumor detection and timely treatment response. These challenges have often only been examined individually, impeding the clinical translation of fluorescent probes. By simultaneously optimizing these design criteria, we created a new generation of near-infrared fluorescent core−shell silica-based nanoparticles (C dots) tuned to hydrodynamic diameters of 3.3 and 6.0 nm with improved photophysical characteristics over the parent dye. A neutral organic coating prevented adsorption of serum proteins and facilitated efficient urinary excretion. Detailed particle biodistribution studies were performed using more quantitative ex vivo fluorescence detection protocols and combined optical-PET imaging. The results suggest that this new generation of C dots constitutes a promising clinically translatable materials platform which may be adapted for tumor targeting and treatment.

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Calibration curves, in vivo whole body imaging of mice injected with dots, and urine concentration and excretion data. This material is available free of charge via the Internet at http://pubs.acs.org.

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