ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Recently Viewed
You have not visited any articles yet, Please visit some articles to see contents here.
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2012, 6, 3, 2665-2678
RETURN TO ISSUEPREVArticleNEXT

Nanomagnetic Sensing of Blood Plasma Protein Interactions with Iron Oxide Nanoparticles: Impact on Macrophage Uptake

View Author Information
† Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057 CNRS/Université Paris—Diderot, PRES Sorbonne Paris Cité, 75205 Paris cedex 13, France
‡ GUERBET, BP57400, 95943 Roissy CdG Cedex, France
*Address correspondence to [email protected]
Cite this: ACS Nano 2012, 6, 3, 2665–2678
Publication Date (Web):February 10, 2012
https://doi.org/10.1021/nn300060u
Copyright © 2012 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
2935
Altmetric
-
Citations
128
LEARN ABOUT THESE METRICS
Read OnlinePDF (4 MB)
Get e-Alerts
Supporting Info (1)»
SUBJECTS:

Abstract

Abstract Image

One of the first biointeractions of magnetic nanoparticles with living systems is characterized by nanoparticle–protein complex formation. The proteins dynamically encompass the particles in the protein corona. Here we propose a method based on nanomagnetism that allows a specific in situ monitoring of interactions between iron oxide nanoparticles and blood plasma. Tracking the nanoparticle orientation through their optical birefringence signal induced by an external magnetic field provides a quantitative real-time detection of protein corona at the surface of nanoparticles and assesses eventual onset of particle aggregation. Since some of the plasma proteins may cause particle aggregation, we use magnetic fractionation to separate the nanoparticle clusters (induced by “destabilizing proteins”) from well-dispersed nanoparticles, which remain isolated due to a stabilizing corona involving other different types of proteins. Our study shows that the “biological identity” (obtained after the particles have interacted with proteins) and aggregation state (clustered versus isolated) of nanoparticles depend not only on their initial surface coating, but also on the concentration of plasma in the suspension. Low plasma concentrations (which are generally used in vitro) lead to different protein/nanoparticle complexes than pure plasma, which reflects the in vivo conditions. As a consequence, by mimicking in vivo conditions, we show that macrophages can perceive several different populations of nanoparticle/protein complexes (differing in physical state and in nature of associated proteins) and uptake them to a different extent. When extrapolated to what would happen in vivo, our results suggest a range of cell responses to a variety of nanoparticle/protein complexes which circulate in the body, thereby impacting their tissue distribution and their efficiency and safety for diagnostic and therapeutic use.

KEYWORDS:

Supporting Information

ARTICLE SECTIONS
Jump To

Figures showing TEM micrographs and the first magnetization curve at room temperature of the different NP samples, the evolution of the NP hydrodynamic radius as a function of time in plasma solution at different concentration, the SDS-PAGE and Coomassie Brilliant Blue staining of different NP samples diluted in water, the SDS-PAGE and the Coomassie Brilliant Blue staining of proteins absorbed on NPs in clustered and nonclustered fractions, the scheme of the experimental magneto-optical device and tables listing the time evolution of the hydrodynamic radius and stretching exponent for the different NP fractions dispersed in RPMI medium and dispersed in water after 1 h preincubation in pure plasma or without preincubation in plasma. This material is available free of charge via the Internet at http://pubs.acs.org.

Terms & Conditions

Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

Cited By

This article is cited by 128 publications.

  1. Rui Rong, Yun Zhang, Weihang Tan, Tingting Hu, Xiaoqin Wang, Zongxiang Gui, Jiachun Gong, Xiaolong Xu. Evidence of Translocation of Oral Zn2+ Doped Magnetite Nanoparticles Across the Small Intestinal Wall of Mice and Deposition in Spleen: Unique Advantage in Biomedical Applications. ACS Applied Bio Materials 2020, 3 (11) , 7919-7929. https://doi.org/10.1021/acsabm.0c01038
  2. Jianlei Shen, Le Liang, Mingshu Xiao, Xiaodong Xie, Fei Wang, Qian Li, Zhilei Ge, Jiang Li, Jiye Shi, Lihua Wang, Li Li, Hao Pei, Chunhai Fan. Fractal Nanoplasmonic Labels for Supermultiplex Imaging in Single Cells. Journal of the American Chemical Society 2019, 141 (30) , 11938-11946. https://doi.org/10.1021/jacs.9b03498
  3. Ana C. Bohórquez, Mythreyi Unni, Sayali Belsare, Andreina Chiu-Lam, Lori Rice, Christine Pampo, Dietmar Siemann, Carlos Rinaldi. Stability and Mobility of Magnetic Nanoparticles in Biological Environments Determined from Dynamic Magnetic Susceptibility Measurements. Bioconjugate Chemistry 2018, 29 (8) , 2793-2805. https://doi.org/10.1021/acs.bioconjchem.8b00419
  4. Junjie Chen, Sarah Klem, Alexis K. Jones, Bradford Orr, and Mark M. Banaszak Holl . Folate-Binding Protein Self-Aggregation Drives Agglomeration of Folic Acid Targeted Iron Oxide Nanoparticles. Bioconjugate Chemistry 2017, 28 (1) , 81-87. https://doi.org/10.1021/acs.bioconjchem.6b00526
  5. Nohyun Lee, Dongwon Yoo, Daishun Ling, Mi Hyeon Cho, Taeghwan Hyeon, and Jinwoo Cheon . Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy. Chemical Reviews 2015, 115 (19) , 10637-10689. https://doi.org/10.1021/acs.chemrev.5b00112
  6. Jelena Kolosnjaj-Tabi, Yasir Javed, Lénaic Lartigue, Jeanne Volatron, Dan Elgrabli, Iris Marangon, Giammarino Pugliese, Benoit Caron, Albert Figuerola, Nathalie Luciani, Teresa Pellegrino, Damien Alloyeau, and Florence Gazeau . The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice. ACS Nano 2015, 9 (8) , 7925-7939. https://doi.org/10.1021/acsnano.5b00042
  7. Zhifang Ma, Jing Bai, and Xiue Jiang . Monitoring of the Enzymatic Degradation of Protein Corona and Evaluating the Accompanying Cytotoxicity of Nanoparticles. ACS Applied Materials & Interfaces 2015, 7 (32) , 17614-17622. https://doi.org/10.1021/acsami.5b05744
  8. Mariana Köber, Maria Moros, Laura Franco Fraguas, Valeria Grazú, Jesus M. de la Fuente, Mónica Luna, and Fernando Briones . Nanoparticle-Mediated Monitoring of Carbohydrate–Lectin Interactions Using Transient Magnetic Birefringence. Analytical Chemistry 2014, 86 (24) , 12159-12165. https://doi.org/10.1021/ac503122y
  9. Parisa Sadatmousavi, Eugene Kovalenko, and P. Chen . Thermodynamic Characterization of the Interaction between a Peptide–Drug Complex and Serum Proteins. Langmuir 2014, 30 (37) , 11122-11130. https://doi.org/10.1021/la502422u
  10. Matthew J. Ware, Biana Godin, Neenu Singh, Ravish Majithia, Sabeel Shamsudeen, Rita E. Serda, Kenith E. Meissner, Paul Rees, and Huw D. Summers . Analysis of the Influence of Cell Heterogeneity on Nanoparticle Dose Response. ACS Nano 2014, 8 (7) , 6693-6700. https://doi.org/10.1021/nn502356f
  11. Carl D. Walkey, Jonathan B. Olsen, Fayi Song, Rong Liu, Hongbo Guo, D. Wesley H. Olsen, Yoram Cohen, Andrew Emili, and Warren C. W. Chan . Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles. ACS Nano 2014, 8 (3) , 2439-2455. https://doi.org/10.1021/nn406018q
  12. Zhifang Ma, Jing Bai, Yichen Wang, and Xiue Jiang . Impact of Shape and Pore Size of Mesoporous Silica Nanoparticles on Serum Protein Adsorption and RBCs Hemolysis. ACS Applied Materials & Interfaces 2014, 6 (4) , 2431-2438. https://doi.org/10.1021/am404860q
  13. Stefano P. Boulos, Tyler A. Davis, Jie An Yang, Samuel E. Lohse, Alaaldin M. Alkilany, Lisa A. Holland, and Catherine J. Murphy . Nanoparticle–Protein Interactions: A Thermodynamic and Kinetic Study of the Adsorption of Bovine Serum Albumin to Gold Nanoparticle Surfaces. Langmuir 2013, 29 (48) , 14984-14996. https://doi.org/10.1021/la402920f
  14. Huw D. Summers, Martyn R. Brown, Mark D. Holton, James A. Tonkin, Nicole Hondow, Andrew P. Brown, Rik Brydson, and Paul Rees . Quantification of Nanoparticle Dose and Vesicular Inheritance in Proliferating Cells. ACS Nano 2013, 7 (7) , 6129-6137. https://doi.org/10.1021/nn4019619
  15. Lénaic Lartigue, Damien Alloyeau, Jelena Kolosnjaj-Tabi, Yasir Javed, Pablo Guardia, Andreas Riedinger, Christine Péchoux, Teresa Pellegrino, Claire Wilhelm, and Florence Gazeau . Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring. ACS Nano 2013, 7 (5) , 3939-3952. https://doi.org/10.1021/nn305719y
  16. Xiangsheng Liu, Xiaodong Xie, Jinhong Jiang, Matthew Lin, Emily Zheng, Waveley Qiu, Iwin Yeung, Motao Zhu, Qinglin Li, Tian Xia, Huan Meng. Use of Nanoformulation to Target Macrophages for Disease Treatment. Advanced Functional Materials 2021, 16 , 2104487. https://doi.org/10.1002/adfm.202104487
  17. Martin Rabel, Paul Warncke, Maria Thürmer, Cordula Grüttner, Christian Bergemann, Heinz-Dieter Kurland, Frank A. Müller, Andreas Koeberle, Dagmar Fischer. The differences of the impact of a lipid and protein corona on the colloidal stability, toxicity, and degradation behavior of iron oxide nanoparticles. Nanoscale 2021, 13 (20) , 9415-9435. https://doi.org/10.1039/D0NR09053K
  18. B. Alshahrani, H. I. ElSaeedy, S. Fares, A. H. Korna, H. A. Yakout, A. H. Ashour, Ramy Amer Fahim, Ahmad S. Kodous, Mohamed Gobara, M. I. A. Abdel Maksoud. Structural, optical, and magnetic properties of nanostructured Ag-substituted Co-Zn ferrites: insights on anticancer and antiproliferative activities. Journal of Materials Science: Materials in Electronics 2021, 32 (9) , 12383-12401. https://doi.org/10.1007/s10854-021-05870-1
  19. Fazel Abdolahpur Monikh, Latifeh Chupani, Isabel Karkossa, Zdenko Gardian, Daniel Arenas-Lago, Martin von Bergen, Kristin Schubert, Veronika Piackova, Eliska Zuskova, Wim Jiskoot, Martina G. Vijver, Willie J.G.M. Peijnenburg. An environmental ecocorona influences the formation and evolution of the biological corona on the surface of single-walled carbon nanotubes. NanoImpact 2021, 22 , 100315. https://doi.org/10.1016/j.impact.2021.100315
  20. Tony Bewersdorff, Emanuel A. Glitscher, Julian Bergueiro, Murat Eravci, Enrico Miceli, Andrea Haase, Marcelo Calderón. The influence of shape and charge on protein corona composition in common gold nanostructures. Materials Science and Engineering: C 2020, 117 , 111270. https://doi.org/10.1016/j.msec.2020.111270
  21. Subrata Das, Sangharaj Diyali, Gopal Vinothini, Balaji Perumalsamy, Gowdhami Balakrishnan, Thirumurugan Ramasamy, Dhanasekaran Dharumadurai, Bhaskar Biswas. Synthesis, morphological analysis, antibacterial activity of iron oxide nanoparticles and the cytotoxic effect on lung cancer cell line. Heliyon 2020, 6 (9) , e04953. https://doi.org/10.1016/j.heliyon.2020.e04953
  22. A. Van de Walle, J.E. Perez, A. Abou-Hassan, M. Hémadi, N. Luciani, C. Wilhelm. Magnetic nanoparticles in regenerative medicine: what of their fate and impact in stem cells?. Materials Today Nano 2020, 11 , 100084. https://doi.org/10.1016/j.mtnano.2020.100084
  23. Fakhrossadat Mohammadi, Marzieh Moeeni, Chengnan Li, Rabah Boukherroub, Sabine Szunerits. Interaction of cellulose and nitrodopamine coated superparamagnetic iron oxide nanoparticles with alpha-lactalbumin. RSC Advances 2020, 10 (16) , 9704-9716. https://doi.org/10.1039/C9RA09045B
  24. Sebastian Schwaminger, Christopher Syhr, Sonja Berensmeier. Controlled Synthesis of Magnetic Iron Oxide Nanoparticles: Magnetite or Maghemite?. Crystals 2020, 10 (3) , 214. https://doi.org/10.3390/cryst10030214
  25. Meichen Guo, Hang Song, Kai Li, Minchao Ma, Yang Liu, Qiang Fu, Zhonggui He. A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on. Medicinal Research Reviews 2020, 40 (1) , 27-53. https://doi.org/10.1002/med.21595
  26. Idoia Mikelez-Alonso, Antonio Aires, Aitziber L. Cortajarena. Cancer Nano-Immunotherapy from the Injection to the Target: The Role of Protein Corona. International Journal of Molecular Sciences 2020, 21 (2) , 519. https://doi.org/10.3390/ijms21020519
  27. Ulrike Martens, Dominique Böttcher, Delphine Talbot, Uwe Bornscheuer, Ali Abou-Hassan, Mihaela Delcea. Maghemite nanoparticles stabilize the protein corona formed with transferrin presenting different iron-saturation levels. Nanoscale 2019, 11 (34) , 16063-16070. https://doi.org/10.1039/C9NR04967C
  28. Vo-Van Giau, Yoon-Hee Park, Kyu-Hwan Shim, Sang-Wook Son, Seong-Soo A. An. Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media. Frontiers of Chemical Science and Engineering 2019, 13 (1) , 90-97. https://doi.org/10.1007/s11705-018-1766-z
  29. Bernadeta Dobosz, Ryszard Krzyminiewski. Electron Spin Resonance (ESR) Study of Human Blood and Its Interaction with Magnetite Nanoparticles. 2019,,, 1-22. https://doi.org/10.1007/978-981-13-2230-3_1
  30. Haifeng Zhou, Dejian Chen, Guoxia Ran, Qijun Song, Jean-Francois Masson. Controllable design of polycrystalline synergies: Hybrid FeOx nanoparticles applicable to electrochemical sensing antineoplastic drug in mammalian cells. Sensors and Actuators B: Chemical 2018, 275 , 1-9. https://doi.org/10.1016/j.snb.2018.07.155
  31. Sherleen Xue-Fu Adamson, Zhoumeng Lin, Ran Chen, Lisa Kobos, Jonathan Shannahan. Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states. Toxicology in Vitro 2018, 51 , 40-49. https://doi.org/10.1016/j.tiv.2018.05.003
  32. Nahid Shahabadi, Aref Khorshidi, Hossein Zhaleh, Soheila Kashanian. Synthesis, characterization, cytotoxicity and DNA binding studies of Fe 3 O 4 @SiO 2 nanoparticles coated by an antiviral drug lamivudine. Journal of Drug Delivery Science and Technology 2018, 46 , 55-65. https://doi.org/10.1016/j.jddst.2018.04.016
  33. JC. Brisset, F. Gazeau, C. Corot, N. Nighoghossian, Y. Berthezène, E. Canet-Soulas, M. Wiart. INFLAM – INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking: A Multiscale Approach of Tissue Microenvironment, Iron Nanostructure and Iron Biotransformation. IRBM 2018, 39 (2) , 93-102. https://doi.org/10.1016/j.irbm.2018.02.002
  34. Fahimeh Charbgoo, Mojgan Nejabat, Khalil Abnous, Fatemeh Soltani, Seyed Mohammad Taghdisi, Mona Alibolandi, W. Thomas Shier, Terry W.J. Steele, Mohammad Ramezani. Gold nanoparticle should understand protein corona for being a clinical nanomaterial. Journal of Controlled Release 2018, 272 , 39-53. https://doi.org/10.1016/j.jconrel.2018.01.002
  35. Huating Kong, Kai Xia, Ning Ren, Yunzhi Cui, Renduo Liu, Qingnuan Li, Min Lv, Jiye Shi, Qinglong Yan, Zhifen Cui, Chunhai Fan, Ying Zhu, Lihua Wang. Serum protein corona-responsive autophagy tuning in cells. Nanoscale 2018, 10 (37) , 18055-18063. https://doi.org/10.1039/C8NR05770B
  36. Natalia Feiner-Gracia, Michaela Beck, Sílvia Pujals, Sébastien Tosi, Tamoghna Mandal, Christian Buske, Mika Linden, Lorenzo Albertazzi. Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona. Small 2017, 13 (41) , 1701631. https://doi.org/10.1002/smll.201701631
  37. Ye Liu, Bereket Workalemahu, Xingyu Jiang. The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo. Small 2017, 13 (43) , 1701815. https://doi.org/10.1002/smll.201701815
  38. Violet Aileen Senapati, Krupa Kansara, Rishi Shanker, Alok Dhawan, Ashutosh Kumar. Monitoring characteristics and genotoxic effects of engineered nanoparticle–protein corona. Mutagenesis 2017, 32 (5) , 479-490. https://doi.org/10.1093/mutage/gex028
  39. Yiting Xu, Jiamei Huang, Yuntong Li, Meijie Wang, Ying Cao, Conghui Yuan, Birong Zeng, Lizong Dai. A novel hybrid polyhedral oligomeric silsesquioxane-based copolymer with zwitterion: Synthesis, characterization, self-assembly behavior and pH responsive property. Macromolecular Research 2017, 25 (8) , 817-825. https://doi.org/10.1007/s13233-017-5098-5
  40. Seyyed Salili, Matthew Worden, Ahlam Nemati, Donald Miller, Torsten Hegmann. Synthesis of Distinct Iron Oxide Nanomaterial Shapes Using Lyotropic Liquid Crystal Solvents. Nanomaterials 2017, 7 (8) , 211. https://doi.org/10.3390/nano7080211
  41. Tina Skorjanc, Farah Benyettou, John-Carl Olsen, Ali Trabolsi. Design of Organic Macrocycle-Modified Iron Oxide Nanoparticles for Drug Delivery. Chemistry - A European Journal 2017, 23 (35) , 8333-8347. https://doi.org/10.1002/chem.201605246
  42. Na Zhu, Houchen Chang, Andrew Franson, Tao Liu, Xufeng Zhang, E. Johnston-Halperin, Mingzhong Wu, Hong X. Tang. Patterned growth of crystalline Y 3 Fe 5 O 12 nanostructures with engineered magnetic shape anisotropy. Applied Physics Letters 2017, 110 (25) , 252401. https://doi.org/10.1063/1.4986474
  43. Ran Chen, Jim E. Riviere. Biological and environmental surface interactions of nanomaterials: characterization, modeling, and prediction. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2017, 9 (3) , e1440. https://doi.org/10.1002/wnan.1440
  44. Legha Ansari, Bizhan Malaekeh-Nikouei. Magnetic silica nanocomposites for magnetic hyperthermia applications. International Journal of Hyperthermia 2017, 33 (3) , 354-363. https://doi.org/10.1080/02656736.2016.1243736
  45. Dandan Chen, Nancy A. Monteiro-Riviere, Leshuai W. Zhang. Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2017, 9 (2) , e1419. https://doi.org/10.1002/wnan.1419
  46. Richard J. Murdock, Shawn A. Putnam, Soumen Das, Ankur Gupta, Elyse D. Z. Chase, Sudipta Seal. High‐Throughput, Protein‐Targeted Biomolecular Detection Using Frequency‐Domain Faraday Rotation Spectroscopy. Small 2017, 13 (12) , 1602862. https://doi.org/10.1002/smll.201602862
  47. Xiongwei Hu, Xiaochun Dong, Yi Lu, Jianping Qi, Weili Zhao, Wei Wu. Bioimaging of nanoparticles: the crucial role of discriminating nanoparticles from free probes. Drug Discovery Today 2017, 22 (2) , 382-387. https://doi.org/10.1016/j.drudis.2016.10.002
  48. Jeanne Volatron, Florent Carn, Jelena Kolosnjaj-Tabi, Yasir Javed, Quoc Lam Vuong, Yves Gossuin, Christine Ménager, Nathalie Luciani, Gaëlle Charron, Miryana Hémadi, Damien Alloyeau, Florence Gazeau. Ferritin Protein Regulates the Degradation of Iron Oxide Nanoparticles. Small 2017, 13 (2) , 1602030. https://doi.org/10.1002/smll.201602030
  49. Jelena Kolosnjaj-Tabi, Jeanne Volatron, Florence Gazeau. Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging. 2017,,, 9-41. https://doi.org/10.1007/978-3-319-42169-8_2
  50. Takashi Nagano, Kazuya Nagano, Hiromi Nabeshi, Tokuyuki Yoshida, Haruhiko Kamada, Shin-ichi Tsunoda, Jian-Qing Gao, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi. Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes. Biological & Pharmaceutical Bulletin 2017, 40 (5) , 726-728. https://doi.org/10.1248/bpb.b16-00917
  51. Emilia Zachanowicz, Aleksander Zięcina, Paulina A. Mikołajczyk, Krzysztof Rogacki, Małgorzata Małecka, Krzysztof Marycz, Monika Marędziak, Błazej Poźniak, Marta Nowakowska, Marta Tikhomirov, Julia Miller, Rafał J. Wiglusz, Robert Pązik. Cytotoxic Effects of Co 1- x Mn x Fe 2 O 4 Ferrite Nanoparticles Synthesized under Non-Hydrolytic Conditions (Bradley's Reaction) - In Vitro. European Journal of Inorganic Chemistry 2016, 2016 (34) , 5315-5323. https://doi.org/10.1002/ejic.201600720
  52. Sandeep K. Vaishanav, Kumudini Chandraker, Jyoti Korram, Rekha Nagwanshi, Kallol K. Ghosh, Manmohan L. Satnami. Protein nanoparticle interaction: A spectrophotometric approach for adsorption kinetics and binding studies. Journal of Molecular Structure 2016, 1117 , 300-310. https://doi.org/10.1016/j.molstruc.2016.03.087
  53. Jonathan H. Shannahan, Kristofer S. Fritz, Achyut J. Raghavendra, Ramakrishna Podila, Indushekar Persaud, Jared M. Brown. From the Cover: Disease-Induced Disparities in Formation of the Nanoparticle-Biocorona and the Toxicological Consequences. Toxicological Sciences 2016, 152 (2) , 406-416. https://doi.org/10.1093/toxsci/kfw097
  54. Amanda K. Andriola Silva, Ana Espinosa, Jelena Kolosnjaj‐Tabi, Claire Wilhelm, Florence Gazeau. Medical Applications of Iron Oxide Nanoparticles. 2016,,, 425-472. https://doi.org/10.1002/9783527691395.ch18
  55. Jacek K. Stolarczyk, Andras Deak, Dermot F. Brougham. Nanoparticle Clusters: Assembly and Control Over Internal Order, Current Capabilities, and Future Potential. Advanced Materials 2016, 28 (27) , 5400-5424. https://doi.org/10.1002/adma.201505350
  56. Jelena Kolosnjaj-Tabi, Lénaic Lartigue, Yasir Javed, Nathalie Luciani, Teresa Pellegrino, Claire Wilhelm, Damien Alloyeau, Florence Gazeau. Biotransformations of magnetic nanoparticles in the body. Nano Today 2016, 11 (3) , 280-284. https://doi.org/10.1016/j.nantod.2015.10.001
  57. Stefan Schrittwieser, Beatriz Pelaz, Wolfgang Parak, Sergio Lentijo-Mozo, Katerina Soulantica, Jan Dieckhoff, Frank Ludwig, Annegret Guenther, Andreas Tschöpe, Joerg Schotter. Homogeneous Biosensing Based on Magnetic Particle Labels. Sensors 2016, 16 (6) , 828. https://doi.org/10.3390/s16060828
  58. Yaqing Qie, Hengfeng Yuan, Christina A. von Roemeling, Yuanxin Chen, Xiujie Liu, Kevin D. Shih, Joshua A. Knight, Han W. Tun, Robert E. Wharen, Wen Jiang, Betty Y.S. Kim. Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes. Scientific Reports 2016, 6 (1) https://doi.org/10.1038/srep26269
  59. Ruth Otero-Lorenzo, Elvira Fantechi, Claudio Sangregorio, Verónica Salgueiriño. Solvothermally Driven Mn Doping and Clustering of Iron Oxide Nanoparticles for Heat Delivery Applications. Chemistry - A European Journal 2016, 22 (19) , 6666-6675. https://doi.org/10.1002/chem.201505049
  60. Nahid Shahabadi, Monireh Falsafi, Kamran Mansouri. Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on [email protected] nanoparticles. Colloids and Surfaces B: Biointerfaces 2016, 141 , 213-222. https://doi.org/10.1016/j.colsurfb.2016.01.054
  61. Marija Kurtinaitiene, Kestutis Mazeika, Simonas Ramanavicius, Vidas Pakstas, Arunas Jagminas. Effect of additives on the hydrothermal synthesis of manganese ferrite nanoparticles. Advances in nano research 2016, 4 (1) , 1-14. https://doi.org/10.12989/anr.2016.4.1.001
  62. Nisha Shankhwar, K Sharma, G Kothiyal, A Srinivasanan. Bioactive Glass and Glass-Ceramics Containing Iron Oxide: Preparation and Properties. 2016,,, 1-47. https://doi.org/10.1201/b19906-2
  63. Matthias G. Wacker. Nanomedicines—A Scientific Toy or an Emerging Market?. 2016,,, 591-614. https://doi.org/10.1007/978-3-319-41421-8_18
  64. Neus Feliu, Dominic Docter, Markus Heine, Pablo del Pino, Sumaira Ashraf, Jelena Kolosnjaj-Tabi, Paolo Macchiarini, Peter Nielsen, Damien Alloyeau, Florence Gazeau, Roland H. Stauber, Wolfgang J. Parak. In vivo degeneration and the fate of inorganic nanoparticles. Chemical Society Reviews 2016, 45 (9) , 2440-2457. https://doi.org/10.1039/C5CS00699F
  65. Alioscka A. Sousa, Sergio A. Hassan, Luiza L. Knittel, Andrea Balbo, Maria A. Aronova, Patrick H. Brown, Peter Schuck, Richard D. Leapman. Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations. Nanoscale 2016, 8 (12) , 6577-6588. https://doi.org/10.1039/C5NR07642K
  66. Francesco Vita, Helena Gavilán, Francesca Rossi, César de Julián Fernández, Andrea Secchi, Arturo Arduini, Franca Albertini, M. Puerto Morales. Tuning morphology and magnetism of magnetite nanoparticles by calix[8]arene-induced oriented aggregation. CrystEngComm 2016, 18 (44) , 8591-8598. https://doi.org/10.1039/C6CE01252C
  67. Andrew P. Ault, Diana I. Stark, Jessica L. Axson, Justin N. Keeney, Andrew D. Maynard, Ingrid L. Bergin, Martin A. Philbert. Protein corona-induced modification of silver nanoparticle aggregation in simulated gastric fluid. Environmental Science: Nano 2016, 3 (6) , 1510-1520. https://doi.org/10.1039/C6EN00278A
  68. Wei Wu, Chang Zhong Jiang, Vellaisamy A. L. Roy. Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications. Nanoscale 2016, 8 (47) , 19421-19474. https://doi.org/10.1039/C6NR07542H
  69. Peng Zhao, Meng Cao, Lina Song, Hao Wu, Ke Hu, Bo Chen, Qiwei Wang, Ning Gu. Downregulation of MIM protein inhibits the cellular endocytosis process of magnetic nanoparticles in macrophages. RSC Advances 2016, 6 (99) , 96635-96643. https://doi.org/10.1039/C6RA21530K
  70. Maja Sopotnik, Adrijana Leonardi, Igor Križaj, Peter Dušak, Darko Makovec, Tina Mesarič, Nataša Poklar Ulrih, Ita Junkar, Kristina Sepčić, Damjana Drobne. Comparative study of serum protein binding to three different carbon-based nanomaterials. Carbon 2015, 95 , 560-572. https://doi.org/10.1016/j.carbon.2015.08.018
  71. Hisham A. Alhadlaq, Mohd Javed Akhtar, Maqusood Ahamed. Zinc ferrite nanoparticle-induced cytotoxicity and oxidative stress in different human cells. Cell & Bioscience 2015, 5 (1) https://doi.org/10.1186/s13578-015-0046-6
  72. Delina Joseph, Shilpee Sachar, Nand Kishore, Sudeshna Chandra. Mechanistic insights into the interactions of magnetic nanoparticles with bovine serum albumin in presence of surfactants. Colloids and Surfaces B: Biointerfaces 2015, 135 , 596-603. https://doi.org/10.1016/j.colsurfb.2015.08.022
  73. Jia Ma, Zhiping Zhang, Zhanjie Zhang, Jing Huang, You Qin, Xu Li, Hongli Liu, Kunyu Yang, Gang Wu. Magnetic nanoparticle clusters radiosensitise human nasopharyngeal and lung cancer cells after alternating magnetic field treatment. International Journal of Hyperthermia 2015, 31 (7) , 800-812. https://doi.org/10.3109/02656736.2015.1063168
  74. Haijuan Zou, Zhongjuan Wang, Min Feng. Nanocarriers with tunable surface properties to unblock bottlenecks in systemic drug and gene delivery. Journal of Controlled Release 2015, 214 , 121-133. https://doi.org/10.1016/j.jconrel.2015.07.014
  75. C. FANIZZA, S. CASCIARDI, F. INCORONATO, D. CAVALLO, C.L. URSINI, A. CIERVO, R. MAIELLO, A.M. FRESEGNA, A.M. MARCELLONI, D. LEGA, A. ALVINO, S. BAIGUERA. Human epithelial cells exposed to functionalized multiwalled carbon nanotubes: interactions and cell surface modifications. Journal of Microscopy 2015, 259 (3) , 173-184. https://doi.org/10.1111/jmi.12251
  76. , , , Sang-Myung Lee. Dual-modal silica nanoprobes with surface enhanced Raman spectroscopic and fluorescent signals. 2015,,, 952309. https://doi.org/10.1117/12.2190771
  77. Kantrao Saware, Ravindra Mahadappa Aurade, P. D. Kamala Jayanthi, Venkataraman Abbaraju. Modulatory Effect of Citrate Reduced Gold and Biosynthesized Silver Nanoparticles on α -Amylase Activity. Journal of Nanoparticles 2015, 2015 , 1-9. https://doi.org/10.1155/2015/829718
  78. Tokuyuki Yoshida, Yasuo Yoshioka, Yuki Morishita, Michihiko Aoyama, Saeko Tochigi, Toshiro Hirai, Kota Tanaka, Kazuya Nagano, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Kazuma Higashisaka, Yasuo Tsutsumi. Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice. Nanotechnology 2015, 26 (24) , 245101. https://doi.org/10.1088/0957-4484/26/24/245101
  79. Mazen M El-Hammadi, José L Arias. Iron oxide-based multifunctional nanoparticulate systems for biomedical applications: a patent review (2008 – present). Expert Opinion on Therapeutic Patents 2015, 25 (6) , 691-709. https://doi.org/10.1517/13543776.2015.1028358
  80. Jeotikanta Mohapatra, Arijit Mitra, D. Bahadur, M. Aslam. Superspin glass behavior of self-interacting CoFe2O4 nanoparticles. Journal of Alloys and Compounds 2015, 628 , 416-423. https://doi.org/10.1016/j.jallcom.2014.12.197
  81. Hanna L. Karlsson, Muhammet S. Toprak, Bengt Fadeel. Toxicity of Metal and Metal Oxide Nanoparticles. 2015,,, 75-112. https://doi.org/10.1016/B978-0-444-59453-2.00004-4
  82. Ana Espinosa, Mathieu Bugnet, Guillaume Radtke, Sophie Neveu, Gianluigi A. Botton, Claire Wilhelm, Ali Abou-Hassan. Can magneto-plasmonic nanohybrids efficiently combine photothermia with magnetic hyperthermia?. Nanoscale 2015, 7 (45) , 18872-18877. https://doi.org/10.1039/C5NR06168G
  83. R R Wildeboer, P Southern, Q A Pankhurst. On the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia materials. Journal of Physics D: Applied Physics 2014, 47 (49) , 495003. https://doi.org/10.1088/0022-3727/47/49/495003
  84. Nagarjun V Konduru, Kimberly M Murdaugh, Georgios A Sotiriou, Thomas C Donaghey, Philip Demokritou, Joseph D Brain, Ramon M Molina. Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles. Particle and Fibre Toxicology 2014, 11 (1) https://doi.org/10.1186/s12989-014-0044-6
  85. Yu. L. Raikher, V.I. Stepanov. Physical aspects of magnetic hyperthermia: Low-frequency ac field absorption in a magnetic colloid. Journal of Magnetism and Magnetic Materials 2014, 368 , 421-427. https://doi.org/10.1016/j.jmmm.2014.01.070
  86. Chiara Fedeli, Daniela Segat, Regina Tavano, Giorgia De Franceschi, Patrizia Polverino de Laureto, Elisa Lubian, Francesco Selvestrel, Fabrizio Mancin, Emanuele Papini. Variations of the corona HDL:albumin ratio determine distinct effects of amorphous SiO 2 nanoparticles on monocytes and macrophages in serum. Nanomedicine 2014, 9 (16) , 2481-2497. https://doi.org/10.2217/nnm.14.22
  87. Neill J Liptrott, Emily Kendall, Daniel J Nieves, John Farrell, Steve Rannard, David G Fernig, Andrew Owen. Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a ‘mixed matrix’. Nanomedicine 2014, 9 (16) , 2467-2479. https://doi.org/10.2217/nnm.14.38
  88. Pablo Guardia, Andreas Riedinger, Hamilton Kakwere, Florence Gazeau, Teresa Pellegrino. Magnetic Nanoparticles for Magnetic Hyperthermia and Controlled Drug Delivery. 2014,,, 139-172. https://doi.org/10.1002/9783527675821.ch06
  89. Zhengyan Hu, Hongyan Zhang, Yi Zhang, Ren’an Wu, Hanfa Zou. Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles. Colloids and Surfaces B: Biointerfaces 2014, 121 , 354-361. https://doi.org/10.1016/j.colsurfb.2014.06.016
  90. Yasir Javed, Lénaic Lartigue, Pierre Hugounenq, Quoc Lam Vuong, Yves Gossuin, Rana Bazzi, Claire Wilhelm, Christian Ricolleau, Florence Gazeau, Damien Alloyeau. Biodegradation Mechanisms of Iron Oxide Monocrystalline Nanoflowers and Tunable Shield Effect of Gold Coating. Small 2014, 10 (16) , 3325-3337. https://doi.org/10.1002/smll.201400281
  91. Adriano Boni, Davide Ceratti, Antonella Antonelli, Carla Sfara, Mauro Magnani, Elisabetta Manuali, Sonia Salamida, Alessandro Gozzi, Angelo Bifone. USPIO-loaded red blood cells as a biomimetic MR contrast agent: a relaxometric study. Contrast Media & Molecular Imaging 2014, 9 (3) , 229-236. https://doi.org/10.1002/cmmi.1562
  92. Ana C. Bohorquez, Carlos Rinaldi. In Situ Evaluation of Nanoparticle-Protein Interactions by Dynamic Magnetic Susceptibility Measurements. Particle & Particle Systems Characterization 2014, 31 (5) , 561-570. https://doi.org/10.1002/ppsc.201300296
  93. Jan Ungelenk, Manfred Speldrich, Richard Dronskowski, Claus Feldmann. Polyol-mediated low-temperature synthesis of crystalline tungstate nanoparticles MWO4 (M = Mn, Fe, Co, Ni, Cu, Zn). Solid State Sciences 2014, 31 , 62-69. https://doi.org/10.1016/j.solidstatesciences.2014.02.020
  94. Michele Wabler, Wenlian Zhu, Mohammad Hedayati, Anilchandra Attaluri, Haoming Zhou, Jana Mihalic, Alison Geyh, Theodore L. DeWeese, Robert Ivkov, Dmitri Artemov. Magnetic resonance imaging contrast of iron oxide nanoparticles developed for hyperthermia is dominated by iron content. International Journal of Hyperthermia 2014, 30 (3) , 192-200. https://doi.org/10.3109/02656736.2014.913321
  95. Patrick N. Sisco, Christopher G. Wilson, Davin Chernak, Jessica C. Clark, Elissa M. Grzincic, Kayla Ako-Asare, Edie C. Goldsmith, Catherine J. Murphy, . Adsorption of Cellular Proteins to Polyelectrolyte-Functionalized Gold Nanorods: A Mechanism for Nanoparticle Regulation of Cell Phenotype?. PLoS ONE 2014, 9 (2) , e86670. https://doi.org/10.1371/journal.pone.0086670
  96. Gang Wang, Guoying Shi, Hongzhi Wang, Qinghong Zhang, Yaogang Li. In Situ Functionalization of Stable 3D Nest-Like Networks in Confined Channels for Microfluidic Enrichment and Detection. Advanced Functional Materials 2014, 24 (7) , 1017-1026. https://doi.org/10.1002/adfm.201301936
  97. Yang Qu, Jianbo Li, Jie Ren, Junzhao Leng, Chao Lin, Donglu Shi. Enhanced synergism of thermo-chemotherapy by combining highly efficient magnetic hyperthermia with magnetothermally-facilitated drug release. Nanoscale 2014, 6 (21) , 12408-12413. https://doi.org/10.1039/C4NR03384A
  98. Jelena Kolosnjaj-Tabi, Yasir Javed, Lénaïc Lartigue, Christine Péchoux, Nathalie Luciani, Damien Alloyeau, Florence Gazeau. Cycle de vie de nanoparticules magnétiques dans l’organisme. Biologie Aujourd'hui 2014, 208 (2) , 177-190. https://doi.org/10.1051/jbio/2014021
  99. Arūnas Jagminas, Kęstutis Mažeika, Rokas Kondrotas, Marija Kurtinaitienė, Aldona Jagminienė, Agnė Mikalauskaitė. Functionalization of Cobalt Ferrite Nanoparticles by a Vitamin C-Assisted Covering with Gold. Nanomaterials and Nanotechnology 2014, 4 , 11. https://doi.org/10.5772/58453
  100. Sacha Loeve, Bernadette Bensaude Vincent, Florence Gazeau. Nanomedicine metaphors: From war to care. Emergence of an oecological approach. Nano Today 2013, 8 (6) , 560-565. https://doi.org/10.1016/j.nantod.2013.08.003
Load all citations

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE