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Quantitative and Multiplexed MicroRNA Sensing in Living Cells Based on Peptide Nucleic Acid and Nano Graphene Oxide (PANGO)

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    Quantitative and Multiplexed MicroRNA Sensing in Living Cells Based on Peptide Nucleic Acid and Nano Graphene Oxide (PANGO)
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    † Department of Chemistry, Seoul National University, Seoul, 151-747, Republic of Korea
    ‡ Center for RNA Research, Institute for Basic Science (IBS), Seoul, 151-747, Republic of Korea
    § School of Biological Sciences, Seoul National University, Seoul 151-747, Republic of Korea
    ⊥ Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea
    *Address correspondence to [email protected]
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    ACS Nano

    Cite this: ACS Nano 2013, 7, 7, 5882–5891
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    https://doi.org/10.1021/nn401183s
    Published June 14, 2013
    Copyright © 2013 American Chemical Society
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    MicroRNA (miRNA) is an important small RNA which regulates diverse gene expression at the post-transcriptional level. miRNAs are considered as important biomarkers since abnormal expression of specific miRNAs is associated with many diseases including cancer and diabetes. Therefore, it is important to develop biosensors to quantitatively detect miRNA expression levels. Here, we develop a nanosized graphene oxide (NGO) based miRNA sensor, which allows quantitative monitoring of target miRNA expression levels in living cells. The strategy is based on tight binding of NGO with peptide nucleic acid (PNA) probes, resulting in fluorescence quenching of the dye that is conjugated to the PNA, and subsequent recovery of the fluorescence upon addition of target miRNA. PNA as a probe for miRNA sensing offers many advantages including high sequence specificity, high loading capacity on the NGO surface compared to DNA and resistance against nuclease-mediated degradation. The present miRNA sensor allowed the detection of specific target miRNAs with the detection limit as low as ∼1 pM and the simultaneous monitoring of three different miRNAs in a living cell.

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    This article is cited by 274 publications.

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