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Gold Nanoparticle-Based Activatable Probe for Sensing Ultralow Levels of Prostate-Specific Antigen

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Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China
§ Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20982, United States
Optical Technology Division, Physics Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States
*Address correspondence to [email protected]
Cite this: ACS Nano 2013, 7, 6, 5568–5576
Publication Date (Web):May 19, 2013
https://doi.org/10.1021/nn401837q
Copyright © 2013 American Chemical Society
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Abstract

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It is still in high demand to develop extremely sensitive and accurate clinical tools for biomarkers of interest for early diagnosis and monitoring of diseases. In this report, we present a highly sensitive and compatible gold nanoparticle (AuNP)-based fluorescence-activatable probe for sensing ultralow levels of prostate-specific antigen (PSA) in patient serum samples. The limit of detection of the newly developed probe for PSA was pushed down to 0.032 pg/mL, which is more than 2 orders of magnitude lower than that of the conventional fluorescence probe. The ultrahigh sensitivity of this probe was attributed to the high loading efficiency of the dyes on AuNP surfaces and high fluorescence quenching–unquenching abilities of the dye–AuNP pairs. The efficiency and robustness of this probe were investigated in patient serum samples, demonstrating the great potential of this probe in real-world applications.

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Details of characterizing gold nanoparticles and various conjugates described here can be found in the Supporting Information. This material is available free of charge via the Internet at http://pubs.acs.org.

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