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    Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
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    † Department of Chemistry and Biochemistry
    ‡ Department of Microbiology, Immunology, and Molecular Genetics
    § Department of Medicine
    ⊥ Department of Radiological Sciences, University of California, Los Angeles, California, 90095
    * Address correspondence to [email protected], [email protected], [email protected]
    #These authors contributed equally to this work
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    ACS Nano

    Cite this: ACS Nano 2008, 2, 5, 889–896
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    https://doi.org/10.1021/nn800072t
    Published May 1, 2008
    Copyright © 2008 American Chemical Society
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    Abstract

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    Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.

    Copyright © 2008 American Chemical Society

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    TEM of iron oxide nanocrystals, the gold− and silver−mesoporous silica NPs, and XRD and nitrogen adsorption−desorption analysis. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cite this: ACS Nano 2008, 2, 5, 889–896
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