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Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles

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Department of Chemistry
Department of Chemical Engineering, University of Massachusetts, Amherst, Massachusetts 01003
* Address correspondence to [email protected]
Cite this: ACS Nano 2008, 2, 11, 2213–2218
Publication Date (Web):October 24, 2008
https://doi.org/10.1021/nn800507t
Copyright © 2008 American Chemical Society

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    Abstract

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    Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding with subsequent condensation. Particles with lysine and lysine dendron functionality formed particularly compact complexes and provided highly efficient gene delivery without any observed cytotoxicity. Nanoparticles functionalized with first generation lysine dendrons (NP−LysG1) were ∼28-fold superior to polylysine in reporter gene expression. These amino acid-based nanoparticles were responsive to intracellular glutathione levels, providing a tool for controlled release and concomitant expression of DNA.

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    Nanoparticle and ligand synthesis, binding studies, and transfection efficiencies at varying particle/DNA ratios. This material is available free of charge via the Internet at http://pubs.acs.org.

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