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A-Type Proanthocyanidin Trimers from Cranberry that Inhibit Adherence of Uropathogenic P-Fimbriated Escherichia coli

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Industrial Research, Gracefield Research Center, PO Box 31-310, Lower Hutt, New Zealand, and Philip E. Marucci Center for Blueberry and Cranberry Research, Rutgers University, Chatsworth, New Jersey 08019
Cite this: J. Nat. Prod. 2000, 63, 9, 1225–1228
Publication Date (Web):July 28, 2000
Copyright © 2000 American Chemical Society and American Society of Pharmacognosy

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    Three proanthocyanidin trimers possessing A-type interflavanoid linkages, epicatechin-(4β→6)-epicatechin-(4β→8, 2β→O→7)-epicatechin (4), epicatechin-(4β→8, 2β→O→7)-epicatechin-(4β→8)-epicatechin (5), and epicatechin-(4β→8)-epicatechin-(4β→8, 2β→O→7)-epicatechin (6), were isolated from the ripe fruits of Vaccinium macrocarpon (cranberry) and prevented adherence of P-fimbriated Escherichia coli isolates from the urinary tract to cellular surfaces containing α-Gal(1→4)β-Gal receptor sequences similar to those on uroepithelial cells. The structure of 4 was elucidated by a combination of spectroscopic methods and acid-catalyzed degradation with phloroglucinol. Also isolated were the weakly active epicatechin-(4β→8, 2β→O→7)-epicatechin (procyanidin A2) (3) and the inactive monomer epicatechin (1) and the inactive dimer epicatechin-(4β→8)-epicatechin (procyanidin B2) (2).


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     Gracefield Research Center.

     Rutgers University.

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