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Four New Bioactive Pyrrole-Derived Alkaloids from the Marine Sponge Axinella brevistyla

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    Four New Bioactive Pyrrole-Derived Alkaloids from the Marine Sponge Axinellabrevistyla
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    Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan, Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan, and Institute for Systematics and Ecology (Zoological Museum), University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands
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    Cite this: J. Nat. Prod. 2001, 64, 12, 1576–1578
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    https://doi.org/10.1021/np010280b
    Published November 21, 2001
    Copyright © 2001 American Chemical Society and American Society of Pharmacognosy
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    Abstract

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    Four new alkaloids (1−4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1−4 were antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 μg/disk, respectively. Compounds 1−3 also exhibited cytotoxicity against L1210 cells with IC50 values of 1.1, 0.66, and 2.5 μg/mL, respectively.

    Copyright © 2001 American Chemical Society and American Society of Pharmacognosy

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     To whom correspondence should be addressed. S.T.:  Tel:  +81-76-234-4469. Fax:  +81-76-234-4417. E-mail:  [email protected]. N.F.:  Tel:  +81-3-5841-5299. Fax:  +81-3-5684-0622. E-mail:  anobu@ mail.ecc.u-tokyo.ac.jp.

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     Kanazawa University.

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     The University of Tokyo.

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     University of Amsterdam.

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    Cite this: J. Nat. Prod. 2001, 64, 12, 1576–1578
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np010280b
    Published November 21, 2001
    Copyright © 2001 American Chemical Society and American Society of Pharmacognosy
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