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(+)-epi-α-Bisbolol Is the Wound-Healing Principle of Peperomia galioides: Investigation of the in Vivo Wound-Healing Activity of Related Terpenoids

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Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts 02747, Departamento de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia, Aptdo. Postal 4314, Lima 100, Perú, Departamento de Química, Universidad Peruana Cayetano Heredia, Aptdo. Postal 4314, Lima 100, Perú, and Laboratorios de Investigación y Desarrollo de Ciencia y Tecnología, y Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Aptdo. Postal 4314, Lima 100, Perú
Cite this: J. Nat. Prod. 2001, 64, 10, 1357–1359
Publication Date (Web):October 4, 2001
https://doi.org/10.1021/np0102859
Copyright © 2001 American Chemical Society and American Society of Pharmacognosy

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    Abstract

    Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED50 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).

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     Departamento de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia.

     University of Massachusetts Dartmouth.

    §

     Departamento de Química, Universidad Peruana Cayetano Heredia.

     Laboratorios de Investigación y Desarrollo y Departamento de Microbiología, Universidad Peruana Cayetano Heredia.

     G.B.H. and A.J.V. share senior coauthorship.

    *

     To whom correspondence should be addressed. Tel:  (508) 999-8865. Fax:  (312) 910-6918. E-mail:  [email protected].

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