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Salvinorins D−F, New Neoclerodane Diterpenoids from Salvia divinorum, and an Improved Method for the Isolation of Salvinorin A

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    Salvinorins D−F, New Neoclerodane Diterpenoids from Salvia divinorum, and an Improved Method for the Isolation of Salvinorin A
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    School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2003, 66, 5, 703–705
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    https://doi.org/10.1021/np0205699
    Published April 18, 2003
    Copyright © 2003 American Chemical Society and American Society of Pharmacognosy
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    Abstract

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    Three new neoclerodane diterpenoids, salvinorins D−F (4−6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).

    Copyright © 2003 American Chemical Society and American Society of Pharmacognosy

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    Table of TLC data for compounds 1−6 and NMR spectra (1H, 13C, and DEPT) for compounds 3−6. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2003, 66, 5, 703–705
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np0205699
    Published April 18, 2003
    Copyright © 2003 American Chemical Society and American Society of Pharmacognosy
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