Concise Large-Scale Synthesis of Psilocin and Psilocybin, Principal Hallucinogenic Constituents of “Magic Mushroom”Click to copy article linkArticle link copied!
Abstract
The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal hallucinogenic constituents of “magic mushroom”, were achieved without chromatographic purification. The key step in the synthesis of 2 was the isolation of the dibenzyl-protected intermediate (7) as a zwitterionic derivative (8), which was completely identified by means of 2D NMR analyses.
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To whom correspondence should be addressed. Tel/Fax: +81-3-3700-9165. E-mail: [email protected].
†
Division of Pharmacognosy, Phytochemistry and Narcotics.
‡
Division of Organic Chemistry.
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