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Concise Large-Scale Synthesis of Psilocin and Psilocybin, Principal Hallucinogenic Constituents of “Magic Mushroom”
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    Concise Large-Scale Synthesis of Psilocin and Psilocybin, Principal Hallucinogenic Constituents of “Magic Mushroom”
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    Division of Pharmacognosy, Phytochemistry and Narcotics, and Division of Organic Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2003, 66, 6, 885–887
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np030059u
    Published May 30, 2003
    Copyright © 2003 American Chemical Society and American Society of Pharmacognosy

    Abstract

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    The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal hallucinogenic constituents of “magic mushroom”, were achieved without chromatographic purification. The key step in the synthesis of 2 was the isolation of the dibenzyl-protected intermediate (7) as a zwitterionic derivative (8), which was completely identified by means of 2D NMR analyses.

    Copyright © 2003 American Chemical Society and American Society of Pharmacognosy

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     To whom correspondence should be addressed. Tel/Fax:  +81-3-3700-9165. E-mail:  [email protected].

     Division of Pharmacognosy, Phytochemistry and Narcotics.

     Division of Organic Chemistry.

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    This article is cited by 67 publications.

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2003, 66, 6, 885–887
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np030059u
    Published May 30, 2003
    Copyright © 2003 American Chemical Society and American Society of Pharmacognosy

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