ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Natural Products as Sources of New Drugs over the Period 1981−2002

View Author Information
Natural Products Branch and Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892
Cite this: J. Nat. Prod. 2003, 66, 7, 1022–1037
Publication Date (Web):June 12, 2003
Copyright © Not subject to U.S. Copyright. Published 2003 American Chemical Society and American Society of Pharmacognosy

    Article Views





    Read OnlinePDF (292 KB)


    This review is an updated and expanded version of a paper that was published in this journal in 1997. The time frame has been extended in both directions to include the 22 years from 1981 to 2002, and a new secondary subdivision related to the natural product source but applied to formally synthetic compounds has been introduced, using the concept of a “natural product mimic” or “NM” to join the original primary divisions. From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well. Thus, in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame. In other areas, the influence of natural product structures is quite marked, particularly in the antihypertensive area, where of the 74 formally synthetic drugs, 48 can be traced to natural product structures/mimics. Similarly, with the 10 antimigraine drugs, seven are based on the serotonin molecule or derivatives thereof. Finally, although combinatorial techniques have succeeded as methods of optimizing structures and have, in fact, been used in the optimization of a number of recently approved agents, we have not been able to identify a de novo combinatorial compound approved as a drug in this time frame.


     To whom correspondence should be addressed at NCI-Frederick, P.O. Box B, Frederick, MD, 21702. Tel:  (301) 846-5387. Fax:  (301) 846-6178. E-mail:  [email protected].

     Natural Products Branch, Developmental Therapeutics Program.

     Pharmaceutical Resources Branch, Developmental Therapeutics Program.


     Current address:  1346 34th Ave., Vero Beach, FL 32960.

    Cited By

    This article is cited by 1912 publications.

    1. Ying-Ti Huang, Indrajeet J. Barve, Ganesh P. Pawar, Chung-Ming Sun. Rapid Synthesis of Benzimidazole-Fused Isoindoles by Rh(III)/Ru(II)-Catalyzed [4 + 1] Cascade C–H/N–H Annulation of 2-Arylbenzimidazoles with Alkynoates and Alkynamide. The Journal of Organic Chemistry 2023, 88 (15) , 10916-10924.
    2. Sofiane Hocine, Edouard Duchamp, Akash Mishra, Jean-Marie Fourquez, Stephen Hanessian. Synthesis of Aza-Bridged Perhydroazulene Chimeras of Tropanes and Hederacine A. The Journal of Organic Chemistry 2023, 88 (7) , 4675-4686.
    3. Manish Rawat, Diwan S. Rawat. Cu2O-Decorated Marigold Hollow Alumina Microsphere Nanoparticles as a Robust and Efficient Catalyst for the Synthesis of Isoquinolones. ACS Sustainable Chemistry & Engineering 2022, 10 (30) , 10014-10023.
    4. Kevin A. Scott, Philip B. Cox, Jon T. Njardarson. Phenols in Pharmaceuticals: Analysis of a Recurring Motif. Journal of Medicinal Chemistry 2022, 65 (10) , 7044-7072.
    5. Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom. Journal of Natural Products 2021, 84 (10) , 2700-2708.
    6. Priyanka Upadhyay, Mousumi Bhattacharjee, Saurav Bhattacharya, Manisha Ahir, Arghya Adhikary, Prasun Patra. Silymarin-Loaded, Lactobionic Acid-Conjugated Porous PLGA Nanoparticles Induce Apoptosis in Liver Cancer Cells. ACS Applied Bio Materials 2020, 3 (10) , 7178-7192.
    7. Anne E. Mattingly, Karlie E. Cox, Richard Smith, Roberta J. Melander, Robert K. Ernst, Christian Melander. Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics. ACS Infectious Diseases 2020, 6 (10) , 2629-2640.
    8. David J. Newman, Gordon M. Cragg. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. Journal of Natural Products 2020, 83 (3) , 770-803.
    9. Lingjun Li, Shenlong Huang, Tongpeng Shang, Bo Zhang, Yuanyang Guo, Gongming Zhu, Demin Zhou, Guisheng Zhang, Anlian Zhu, Lihe Zhang. Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands. The Journal of Organic Chemistry 2018, 83 (21) , 13166-13177.
    10. Peter P. Principe, William S. Fisher. Spatial Distribution of Collections Yielding Marine Natural Products. Journal of Natural Products 2018, 81 (10) , 2307-2320.
    11. Hansamali S. Sirinimal, Sebastien P. Hebert, Ganesh Samala, Heng Chen, Gregory J. Rosenhauer, H. Bernhard Schlegel, Jennifer L. Stockdill. Synthetic and Computational Study of Tin-Free Reductive Tandem Cyclizations of Neutral Aminyl Radicals. Organic Letters 2018, 20 (20) , 6340-6344.
    12. Raquel Roldán, Karel Hernandez, Jesús Joglar, Jordi Bujons, Teodor Parella, Israel Sánchez-Moreno, Virgil Hélaine, Marielle Lemaire, Christine Guérard-Hélaine, Wolf-Dieter Fessner, Pere Clapés. Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes. ACS Catalysis 2018, 8 (9) , 8804-8809.
    13. Maryam Elfeki, Mohammad Alanjary, Stefan J. Green, Nadine Ziemert, Brian T. Murphy. Assessing the Efficiency of Cultivation Techniques To Recover Natural Product Biosynthetic Gene Populations from Sediment. ACS Chemical Biology 2018, 13 (8) , 2074-2081.
    14. Shunsuke Kotani, Kosuke Kai, Masaharu Sugiura, and Makoto Nakajima . Sequential Catalysis of Phosphine Oxide for Stereoselective Synthesis of Stereopentads. Organic Letters 2017, 19 (13) , 3672-3675.
    15. Huzefa A. Raja, Andrew N. Miller, Cedric J. Pearce, and Nicholas H. Oberlies . Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community. Journal of Natural Products 2017, 80 (3) , 756-770.
    16. Abhijit Saha, Saswat Mohapatra, Gaurav Das, Batakrishna Jana, Subhajit Ghosh, Debmalya Bhunia, and Surajit Ghosh . Cancer Cell Specific Delivery of Photosystem I Through Integrin Targeted Liposome Shows Significant Anticancer Activity. ACS Applied Materials & Interfaces 2017, 9 (1) , 176-188.
    17. Marcelo Franchin, Pedro Luiz Rosalen, Marcos Guilherme da Cunha, Rangel Leal Silva, David F. Colón, Gabriel Shimizu Bassi, Severino Matias de Alencar, Masaharu Ikegaki, José C. Alves-Filho, Fernando Q. Cunha, John A. Beutler, and Thiago Mattar Cunha . Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB. Journal of Natural Products 2016, 79 (7) , 1828-1833.
    18. Baowei Chen, Ke Yuan, Xin Chen, Ying Yang, Tong Zhang, Yawei Wang, Tiangang Luan, Shichun Zou, and Xiangdong Li . Metagenomic Analysis Revealing Antibiotic Resistance Genes (ARGs) and Their Genetic Compartments in the Tibetan Environment. Environmental Science & Technology 2016, 50 (13) , 6670-6679.
    19. S. Yugandar, S. Konda, G. Parameshwarappa, and H. Ila . One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles via [2 + 2 + 1] Cycloannulation of 1,3-Bishet(aryl)-monothio-1,3-diketones, α-Substituted Methylamines and Sodium Nitrite through α-Nitrosation of Enaminones. The Journal of Organic Chemistry 2016, 81 (13) , 5606-5622.
    20. Edyta M. Grzelak, Changhwa Hwang, Geping Cai, Joo-Won Nam, Mary P. Choules, Wei Gao, David C. Lankin, James B. McAlpine, Surafel G. Mulugeta, José G. Napolitano, Joo-Won Suh, Seung Hwan Yang, Jinhua Cheng, Hanki Lee, Jin-Yong Kim, Sang-Hyun Cho, Guido F. Pauli, Scott G. Franzblau, and Birgit U. Jaki . Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources. ACS Infectious Diseases 2016, 2 (4) , 294-301.
    21. David J. Newman and Gordon M. Cragg . Natural Products as Sources of New Drugs from 1981 to 2014. Journal of Natural Products 2016, 79 (3) , 629-661.
    22. Rita Maria Concetta Di Martino, Angela De Simone, Vincenza Andrisano, Paola Bisignano, Alessandra Bisi, Silvia Gobbi, Angela Rampa, Romana Fato, Christian Bergamini, Daniel I. Perez, Ana Martinez, Giovanni Bottegoni, Andrea Cavalli, and Federica Belluti . Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors. Journal of Medicinal Chemistry 2016, 59 (2) , 531-544.
    23. Anil K. Padala, Raju Ranjith Kumar, S. Athimoolam, and Qazi Naveed Ahmed . Divergent Reactivity of Amino Acid Alkyl Ester Hydrochlorides with 2-Oxoaldehydes: Role of Selenium Dioxide To Promote Regioselective Synthesis of Imidazoles. Organic Letters 2016, 18 (1) , 96-99.
    24. Shengzheng Wang, Kun Fang, Guoqiang Dong, Shuqiang Chen, Na Liu, Zhenyuan Miao, Jianzhong Yao, Jian Li, Wannian Zhang, and Chunquan Sheng . Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents. Journal of Medicinal Chemistry 2015, 58 (16) , 6678-6696.
    25. Kathleen A. Rising, Charisse M. Crenshaw, Hyun Jo Koo, Thangaiah Subramanian, Kareem A. H. Chehade, Courtney Starks, Keith D. Allen, Douglas A. Andres, H. Peter Spielmann, Joseph P. Noel, and Joe Chappell . Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chemical Biology 2015, 10 (7) , 1729-1736.
    26. David Camp, Agatha Garavelas, and Marc Campitelli . Analysis of Physicochemical Properties for Drugs of Natural Origin. Journal of Natural Products 2015, 78 (6) , 1370-1382.
    27. Hong-Bing Wang, Xiao-Yang Wang, Li-Ping Liu, Guo-Wei Qin, and Ting-Guo Kang . Tigliane Diterpenoids from the Euphorbiaceae and Thymelaeaceae Families. Chemical Reviews 2015, 115 (9) , 2975-3011.
    28. Ling Liu, Xiaoyan Chen, Dong Li, Yang Zhang, Li Li, Liangdong Guo, Ya Cao, and Yongsheng Che . Bisabolane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense. Journal of Natural Products 2015, 78 (4) , 746-753.
    29. . All Natural: The Renaissance of Natural Products Chemistry. Organic Letters 2014, 16 (15) , 3849-3855.
    30. Marguerite Prior, Chandramouli Chiruta, Antonio Currais, Josh Goldberg, Justin Ramsey, Richard Dargusch, Pamela A. Maher, and David Schubert . Back to the Future with Phenotypic Screening. ACS Chemical Neuroscience 2014, 5 (7) , 503-513.
    31. Vinay Kumar Pandey and Pazhamalai Anbarasan . One-Pot Cascade Trifluoromethylation/Cyclization of Imides: Synthesis of α-Trifluoromethylated Amine Derivatives. The Journal of Organic Chemistry 2014, 79 (9) , 4154-4160.
    32. Tatsuya Morofuji, Akihiro Shimizu, and Jun-ichi Yoshida . Direct C–N Coupling of Imidazoles with Aromatic and Benzylic Compounds via Electrooxidative C–H Functionalization. Journal of the American Chemical Society 2014, 136 (12) , 4496-4499.
    33. Kandasamy Rajaguru, Rajendran Suresh, Arumugam Mariappan, Shanmugam Muthusubramanian, and Nattamai Bhuvanesh . Erbium Triflate Promoted Multicomponent Synthesis of Highly Substituted Imidazoles. Organic Letters 2014, 16 (3) , 744-747.
    34. Jonghoon Kim, Won Seok Lee, Jaeyoung Koo, Jeongae Lee, and Seung Bum Park . Synthesis and Library Construction of Privileged Tetra-Substituted Δ5-2-Oxopiperazine as β-Turn Structure Mimetics. ACS Combinatorial Science 2014, 16 (1) , 24-32.
    35. Rubí Zamudio-Vázquez, Fernando Albericio, Judit Tulla-Puche, and Keith R. Fox . Thioester Bonds of Thiocoraline Can Be Replaced with NMe-Amide Bridges without Affecting Its DNA-Binding Properties. ACS Medicinal Chemistry Letters 2014, 5 (1) , 45-50.
    36. Lucélia Tavares, Rui Pimpão, Gordon McDougall, Derek Stewart, Ricardo B. Ferreira, and Cláudia N. Santos . Elucidating Phytochemical Production in Juniperus sp.: Seasonality and Response to Stress Situations. Journal of Agricultural and Food Chemistry 2013, 61 (17) , 4044-4052.
    37. Toshio Norikura, Kenshu Fujiwara, Takanori Yanai, Yusuke Sano, Takuto Sato, Takayuki Tsunoda, Keisuke Kushibe, Akiko Todate, Yae Morinaga, Kunihisa Iwai, and Hajime Matsue . p-Terphenyl Derivatives from the Mushroom Thelephora aurantiotincta Suppress the Proliferation of Human Hepatocellular Carcinoma Cells via Iron Chelation. Journal of Agricultural and Food Chemistry 2013, 61 (6) , 1258-1264.
    38. Dan Du, Jun Yan, Jinhong Ren, Haining Lv, Yong Li, Song Xu, Yadan Wang, Shuanggang Ma, Jing Qu, Weibin Tang, Zhuowei Hu, and Shishan Yu . Synthesis, Biological Evaluation, and Molecular Modeling of Glycyrrhizin Derivatives as Potent High-Mobility Group Box-1 Inhibitors with Anti-Heart-Failure Activity in Vivo. Journal of Medicinal Chemistry 2013, 56 (1) , 97-108.
    39. Sheng Tian, Junmei Wang, Youyong Li, Xiaojie Xu, and Tingjun Hou . Drug-likeness Analysis of Traditional Chinese Medicines: Prediction of Drug-likeness Using Machine Learning Approaches. Molecular Pharmaceutics 2012, 9 (10) , 2875-2886.
    40. Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, Jianzhong Yao, Yongqiang Zhang, Zizhao Guo, Wannian Zhang, and Chunquan Sheng . New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations. Journal of Medicinal Chemistry 2012, 55 (17) , 7593-7613.
    41. Jia-Dai Zhai, Dongmei Li, Jing Long, Hao-Liang Zhang, Jian-Ping Lin, Chuan-Jiang Qiu, Quan Zhang, and Yue Chen . Biomimetic Semisynthesis of Arglabin from Parthenolide. The Journal of Organic Chemistry 2012, 77 (16) , 7103-7107.
    42. Andrés Abad, José L. López-Pérez, Esther del Olmo, Luis F. García-Fernández, Andrés Francesch, Chiara Trigili, Isabel Barasoain, José M. Andreu, J. Fernando Díaz, and Arturo San Feliciano . Synthesis and Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins. Journal of Medicinal Chemistry 2012, 55 (15) , 6724-6737.
    43. Andreas G. Tzakos, Vassiliki G. Kontogianni, Maria Tsoumani, Eleni Kyriakou, John Hwa, Francisco A. Rodrigues, and Alexandros D. Tselepis . Exploration of the Antiplatelet Activity Profile of Betulinic Acid on Human Platelets. Journal of Agricultural and Food Chemistry 2012, 60 (28) , 6977-6983.
    44. Hugo Lachance, Stefan Wetzel, Kamal Kumar, and Herbert Waldmann . Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery. Journal of Medicinal Chemistry 2012, 55 (13) , 5989-6001.
    45. Charles L. Cantrell, Franck E. Dayan, and Stephen O. Duke . Natural Products As Sources for New Pesticides. Journal of Natural Products 2012, 75 (6) , 1231-1242.
    46. Guido F. Pauli, Shao-Nong Chen, J. Brent Friesen, James B. McAlpine, and Birgit U. Jaki . Analysis and Purification of Bioactive Natural Products: The AnaPurNa Study. Journal of Natural Products 2012, 75 (6) , 1243-1255.
    47. Jun Xu, Zhenxi Li, Jian Luo, Fan Yang, Ting Liu, Mingyao Liu, Wen-Wei Qiu, and Jie Tang . Synthesis and Biological Evaluation of Heterocyclic Ring-Fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption. Journal of Medicinal Chemistry 2012, 55 (7) , 3122-3134.
    48. David J. Newman and Gordon M. Cragg . Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010. Journal of Natural Products 2012, 75 (3) , 311-335.
    49. Ming Chen and William R. Roush . Highly Stereoselective Synthesis of anti,anti-Dipropionate Stereotriads: A Solution to the Long-Standing Problem of Challenging Mismatched Double Asymmetric Crotylboration Reactions. Journal of the American Chemical Society 2012, 134 (8) , 3925-3931.
    50. Francesco Montalbano, Nuno R. Candeias, Luís F. Veiros, Vânia André, M. Teresa Duarte, Maria R. Bronze, Rui Moreira, and Pedro M. P. Gois . Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework. Organic Letters 2012, 14 (4) , 988-991.
    51. David Camp, Rohan A. Davis, Marc Campitelli, James Ebdon, and Ronald J. Quinn . Drug-like Properties: Guiding Principles for the Design of Natural Product Libraries. Journal of Natural Products 2012, 75 (1) , 72-81.
    52. Viktor Krchňák, Jaroslav Zajíček, Patricia A. Miller, and Marvin J. Miller . Selective Molecular Sequestration with Concurrent Natural Product Functionalization and Derivatization: From Crude Natural Product Extracts to a Single Natural Product Derivative in One Step. The Journal of Organic Chemistry 2011, 76 (24) , 10249-10253.
    53. Nancy Dewi Yuliana, Alfi Khatib, Robert Verpoorte, and Young Hae Choi . Comprehensive Extraction Method Integrated with NMR Metabolomics: A New Bioactivity Screening Method for Plants, Adenosine A1 Receptor Binding Compounds in Orthosiphon stamineus Benth. Analytical Chemistry 2011, 83 (17) , 6902-6906.
    54. Le Diem Huong, Jung-Hyung Shim, Kyeong-Hee Choi, Ji-Ae Shin, Eun-Sun Choi, Hyung-Seop Kim, Sook-Jeong Lee, Sun-Ju Kim, Nam-Pyo Cho, and Sung-Dae Cho . Effect of β-Phenylethyl Isothiocyanate from Cruciferous Vegetables on Growth Inhibition and Apoptosis of Cervical Cancer Cells through the Induction of Death Receptors 4 and 5. Journal of Agricultural and Food Chemistry 2011, 59 (15) , 8124-8131.
    55. Nattha Ingavat, Chulabhorn Mahidol, Somsak Ruchirawat, and Prasat Kittakoop . Asperaculin A, a Sesquiterpenoid from a Marine-Derived Fungus, Aspergillus aculeatus. Journal of Natural Products 2011, 74 (7) , 1650-1652.
    56. Toshio Norikura, Kenshu Fujiwara, Takanobu Narita, Shinya Yamaguchi, Yae Morinaga, Kunihisa, Iwai, and Hajime Matsue . Anticancer Activities of Thelephantin O and Vialinin A Isolated from Thelephora aurantiotincta. Journal of Agricultural and Food Chemistry 2011, 59 (13) , 6974-6979.
    57. Igor V. Magedov, Liliya Frolova, Madhuri Manpadi, Uma devi Bhoga, Hong Tang, Nikolai M. Evdokimov, Olivia George, Kathy Hadje Georgiou, Steffen Renner, Matthäus Getlik, Tiffany L. Kinnibrugh, Manuel A. Fernandes, Severine Van slambrouck, Wim F. A. Steelant, Charles B. Shuster, Snezna Rogelj, Willem A. L. van Otterlo, and Alexander Kornienko . Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis. Journal of Medicinal Chemistry 2011, 54 (12) , 4234-4246.
    58. I. Ayelen Ramallo, Mario O. Salazar, Luciana Mendez, and Ricardo L. E. Furlan . Chemically Engineered Extracts: Source of Bioactive Compounds. Accounts of Chemical Research 2011, 44 (4) , 241-250.
    59. Nikolai M. Evdokimov, Severine Van slambrouck, Petra Heffeter, Lee Tu, Benjamin Le Calvé, Delphine Lamoral-Theys, Carla J. Hooten, Pavel Y. Uglinskii, Snezna Rogelj, Robert Kiss, Wim F. A. Steelant, Walter Berger, Jeremy J. Yang, Cristian G. Bologa, Alexander Kornienko, and Igor V. Magedov . Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 3. Fused Uracil-Containing Heterocycles as Novel Topoisomerase-Targeting Agents. Journal of Medicinal Chemistry 2011, 54 (7) , 2012-2021.
    60. Soumava Santra and Peter R. Andreana . A Rapid, One-Pot, Microwave-Influenced Synthesis of Spiro-2,5-diketopiperazines via a Cascade Ugi/6-Exo-Trig Aza-Michael Reaction. The Journal of Organic Chemistry 2011, 76 (7) , 2261-2264.
    61. Ute Galm, Evelyn Wendt-Pienkowski, Liyan Wang, Sheng-Xiong Huang, Claudia Unsin, Meifeng Tao, Jane M. Coughlin, and Ben Shen . Comparative Analysis of the Biosynthetic Gene Clusters and Pathways for Three Structurally Related Antitumor Antibiotics: Bleomycin, Tallysomycin, and Zorbamycin. Journal of Natural Products 2011, 74 (3) , 526-536.
    62. Luciana Méndez, Mario O. Salazar, I. Ayelen Ramallo, and Ricardo L. E. Furlan . Brominated Extracts As Source of Bioactive Compounds. ACS Combinatorial Science 2011, 13 (2) , 200-204.
    63. Yong-Chul Jeong and Mark G. Moloney . Synthesis of and Tautomerism in 3-Acyltetramic Acids. The Journal of Organic Chemistry 2011, 76 (5) , 1342-1354.
    64. Daniel J. Schmidt, Joshua S. Moskowitz, and Paula T. Hammond . Electrically Triggered Release of a Small Molecule Drug from a Polyelectrolyte Multilayer Coating. Chemistry of Materials 2010, 22 (23) , 6416-6425.
    65. Nicholas A. McGrath, Matthew Brichacek, and Jon T. Njardarson . A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives. Journal of Chemical Education 2010, 87 (12) , 1348-1349.
    66. Jonathan D. Mortison and David H. Sherman. Frontiers and Opportunities in Chemoenzymatic Synthesis. The Journal of Organic Chemistry 2010, 75 (21) , 7041-7051.
    67. Erin E. Carlson. Natural Products as Chemical Probes. ACS Chemical Biology 2010, 5 (7) , 639-653.
    68. Ying Tu, Cynthia Jeffries, Hong Ruan, Cynthia Nelson, David Smithson, Anang A. Shelat, Kristin M. Brown, Xing-Cong Li, John P. Hester, Troy Smillie, Ikhlas A. Khan, Larry Walker, Kip Guy and Bing Yan. Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery. Journal of Natural Products 2010, 73 (4) , 751-754.
    69. Zhaoming Xiong, Robert Busch and E. J. Corey. A Short Total Synthesis of (+)-Omaezakianol via an Epoxide-Initiated Cationic Cascade Reaction. Organic Letters 2010, 12 (7) , 1512-1514.
    70. Yu-Hsin Hsieh, Fang-Hua Chu, Ya-Shin Wang, Shih-Chang Chien, Shang-Tzen Chang, Jei-Fu Shaw, Chieh-Yin Chen, Wen-Wei Hsiao, Yueh-Hsiung Kuo and Sheng-Yang Wang . Antrocamphin A, an Anti-inflammatory Principal from the Fruiting Body of Taiwanofungus camphoratus, and Its Mechanisms. Journal of Agricultural and Food Chemistry 2010, 58 (5) , 3153-3158.
    71. Simone Bonazzi, Oliv Eidam, Stephan Güttinger, Jean-Yves Wach, Ivo Zemp, Ulrike Kutay and Karl Gademann. Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport. Journal of the American Chemical Society 2010, 132 (4) , 1432-1442.
    72. M. PetkovicJ. FergusonA. BohnJ. R. TrindadeI. MartinsC. LeitãoM. B. CarvalhoC. RodriguesH. GarciaR. FerreiraK. R. SeddonL. P. N. RebeloC. Silva Pereira. On the Merge of Fungal Activity with Ionic Liquids towards the Development of New Biotechnological Processes. 2010, 197-207.
    73. Andreas Leinenbach, Ralf Hartmer, Markus Lubeck, Benny Kneissl, Yasser A. Elnakady, Carsten Baessmann, Rolf Müller and Christian G. Huber . Proteome Analysis of Sorangium cellulosum Employing 2D-HPLC-MS/MS and Improved Database Searching Strategies for CID and ETD Fragment Spectra. Journal of Proteome Research 2009, 8 (9) , 4350-4361.
    74. Daniel W. Custar, Thomas P. Zabawa, John Hines, Craig M. Crews and Karl A. Scheidt . Total Synthesis and Structure−Activity Investigation of the Marine Natural Product Neopeltolide. Journal of the American Chemical Society 2009, 131 (34) , 12406-12414.
    75. Gordon M. Cragg, Paul G. Grothaus and David J. Newman. Impact of Natural Products on Developing New Anti-Cancer Agents. Chemical Reviews 2009, 109 (7) , 3012-3043.
    76. Baiyuan Yang, Patricia A. Miller, Ute Möllmann and Marvin J. Miller . Syntheses and Biological Activity Studies of Novel Sterol Analogs from Nitroso Diels−Alder Reactions of Ergosterol. Organic Letters 2009, 11 (13) , 2828-2831.
    77. Jian-Jun Chen, Zheng-Ming Li, Kun Gao, Jin Chang and Xiao-Jun Yao. Vladimuliecins A and B: Cytotoxic Pentacyclic Pregnanols from Vladimiria muliensis. Journal of Natural Products 2009, 72 (6) , 1128-1132.
    78. Josefin Rosén, Johan Gottfries, Sorel Muresan, Anders Backlund and Tudor I. Oprea. Novel Chemical Space Exploration via Natural Products. Journal of Medicinal Chemistry 2009, 52 (7) , 1953-1962.
    79. Hongbo Liu, Hao Jiang, Bradley Haltli, Kerry Kulowski, Elwira Muszynska, Xidong Feng, Mia Summers, Mairead Young, Edmund Graziani, Frank Koehn, Guy T. Carter and Min He. Rapid Cloning and Heterologous Expression of the Meridamycin Biosynthetic Gene Cluster Using a Versatile Escherichia coli−Streptomyces Artificial Chromosome Vector, pSBAC. Journal of Natural Products 2009, 72 (3) , 389-395.
    80. Hung The Nguyen, Marie-Christine Lallemand, Sabrina Boutefnouchet, Sylvie Michel and François Tillequin. Antitumor Psoropermum Xanthones and Sarcomelicope Acridones: Privileged Structures Implied in DNA Alkylation. Journal of Natural Products 2009, 72 (3) , 527-539.
    81. Shang-Gao Liao, Hua-Dong Chen and Jian-Min Yue. Plant Orthoesters. Chemical Reviews 2009, 109 (3) , 1092-1140.
    82. Mahantappa Halimani, S. Prathap Chandran, Sudhir Kashyap, V. M. Jadhav, B. L. V. Prasad, Srinivas Hotha and Souvik Maiti. Dendritic Effect of Ligand-Coated Nanoparticles: Enhanced Apoptotic Activity of Silica−Berberine Nanoconjugates. Langmuir 2009, 25 (4) , 2339-2347.
    83. Dionicio Martinez-Solorio and Michael P. Jennings. Convergent Formal Syntheses of (±)-Brussonol and (±)-Abrotanone via an Intramolecular Marson-Type Cyclization. Organic Letters 2009, 11 (1) , 189-192.
    84. Holly E. Johnson, Sandra A. Banack and Paul Alan Cox. Variability in Content of the Anti-AIDS Drug Candidate Prostratin in Samoan Populations of Homalanthus nutans. Journal of Natural Products 2008, 71 (12) , 2041-2044.
    85. Youcai Hu, Shuanggang Ma, Jianbei Li, Shishan Yu, Jing Qu, Jing Liu and Dan Du. Targeted Isolation and Structure Elucidation of Stilbene Glycosides from the Bark of Lysidice brevicalyx Wei Guided by Biological and Chemical Screening. Journal of Natural Products 2008, 71 (11) , 1800-1805.
    86. Birgit U. Jaki, Scott G. Franzblau, Lucas R. Chadwick, David C. Lankin, Fangqiu Zhang, Yuehong Wang and Guido F. Pauli. Purity−Activity Relationships of Natural Products: The Case of Anti-TB Active Ursolic Acid. Journal of Natural Products 2008, 71 (10) , 1742-1748.
    87. Guido F. Pauli, Samuel M. Pro and J. Brent Friesen. Countercurrent Separation of Natural Products. Journal of Natural Products 2008, 71 (8) , 1489-1508.
    88. Denise C. Endringer, Keller G. Guimarães, Tamara P. Kondratyuk, John M. Pezzuto and Fernão C. Braga. Selective Inhibition of Aromatase by a Dihydroisocoumarin from Xyris pterygoblephara. Journal of Natural Products 2008, 71 (6) , 1082-1084.
    89. Gregory L. Challis. Genome Mining for Novel Natural Product Discovery. Journal of Medicinal Chemistry 2008, 51 (9) , 2618-2628.
    90. Haoran Zhang, Yong Wang and Blaine A. Pfeifer. Bacterial Hosts for Natural Product Production. Molecular Pharmaceutics 2008, 5 (2) , 212-225.
    91. James F. Sanchez, Yi-Ming Chiang and Clay C. C. Wang . Diversity of Polyketide Synthases Found in the Aspergillus and Streptomyces Genomes. Molecular Pharmaceutics 2008, 5 (2) , 226-233.
    92. Patrick Schneider, Mathias Misiek and Dirk Hoffmeister . In Vivo and In Vitro Production Options for Fungal Secondary Metabolites. Molecular Pharmaceutics 2008, 5 (2) , 234-242.
    93. Blaine Pfeifer. Natural Products and Production Systems: Opening Comments. Molecular Pharmaceutics 2008, 5 (2) , 165-166.
    94. Ronald J. Quinn, Anthony R. Carroll, Ngoc B. Pham, Paul Baron, Meredith E. Palframan, Lekha Suraweera, Gregory K. Pierens and Sorel Muresan. Developing a Drug-like Natural Product Library. Journal of Natural Products 2008, 71 (3) , 464-468.
    95. Anita Rudy, Nancy López-Antón, Verena M. Dirsch and Angelika M. Vollmar. The Cephalostatin Way of Apoptosis. Journal of Natural Products 2008, 71 (3) , 482-486.
    96. Christopher T. Walsh. The Chemical Versatility of Natural-Product Assembly Lines. Accounts of Chemical Research 2008, 41 (1) , 4-10.
    97. Aishwarya V. Ramaswamy, Carla M. Sorrels and William H. Gerwick. Cloning and Biochemical Characterization of the Hectochlorin Biosynthetic Gene Cluster from the Marine Cyanobacterium Lyngbya majuscula. Journal of Natural Products 2007, 70 (12) , 1977-1986.
    98. Oliver Schwarz, Sven Jakupovic, Horst-Dieter Ambrosi, Lars Ole Haustedt, Christian Mang and Lutz Müller-Kuhrt. Natural Products in Parallel Chemistry––Novel 5-Lipoxygenase Inhibitors from BIOS-Based Libraries Starting from α-Santonin. Journal of Combinatorial Chemistry 2007, 9 (6) , 1104-1113.
    99. Venkat R. Macherla, Jehnan Liu, Michelle Sunga, Donald J. White, Jennifer Grodberg, Sy Teisan, Kin S. Lam and Barbara C. M. Potts. Lipoxazolidinones A, B, and C: Antibacterial 4-Oxazolidinones from a Marine Actinomycete Isolated from a Guam Marine Sediment. Journal of Natural Products 2007, 70 (9) , 1454-1457.
    100. Xiaolong Chen,, Yuguo Zheng, and, Yinchu Shen. Natural Products with Maleic Anhydride Structure:  Nonadrides, Tautomycin, Chaetomellic Anhydride, and Other Compounds. Chemical Reviews 2007, 107 (5) , 1777-1830.
    Load more citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect