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In Vivo Wound-Healing Activity of Oleanolic Acid Derived from the Acid Hydrolysis of Anredera diffusa

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Departamento de Ciencias Farmacéuticas, Universidad Peruana Cayetano Heredia, Apartado 4314, Lima 100, Perú, Departamento de Microbiología y Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Apartado 4314, Lima 100, Perú, and Department of Chemistry, University of Louisville, Louisville, Kentucky 40292
Cite this: J. Nat. Prod. 2006, 69, 6, 978–979
Publication Date (Web):May 28, 2006
https://doi.org/10.1021/np0601152
Copyright © 2006 American Chemical Society and American Society of Pharmacognosy

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    Abstract

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    Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight.

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    §

     University of Louisville.

     Departamento de Ciencias Farmacéuticas, Universidad Peruana Cayetano Heredia.

     Departamento de Microbiología y Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia.

     A.J.V. and G.B.H. share senior authorship.

    *

     To whom correspondence should be addressed. Tel:  (+1)502-852-5998. Fax:  (+1)502-852-3899. E-mail:  [email protected].

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