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Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants
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    Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants
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    Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, Departamento de Microbiología y Laboratorios de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Perú, Departamento de Ciencias Farmacéuticas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú, Department of Biology, Washington University, St. Louis, Missouri 63130, Departamento de Entomología, Museo de Historia Natural, Universidad Nacional Mayor de San Marcos, Lima, Perú, Confederacion de Nacionalidades Amazónicas del Perú (CONAP), Lima, Perú, and Department of International Health, Johns Hopkins Uiversity School of Public Health, Baltimore, Maryland 21205
    * To whom correspondence should be addressed. Tel: (+1)502-852-5998. Fax: (+1)502-852-3899. E-mail: [email protected]
    †University of Louisville.
    ‡Departamento de Microbiología y Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia.
    §Departamento de Ciencias Farmacéuticas, Universidad Peruana Cayetano Heredia.
    ⊥Washington University, St. Louis.
    ∥Universidad Nacional Mayor de San Marcos.
    ▽Confederacion de Nacionalidades Amazónicas del Perú.
    ○Johns Hopkins University School of Public Health.
    #A.V. and G.B.H. share senior authorship.
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2008, 71, 1, 102–105
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np070560c
    Published December 29, 2007
    Copyright © 2008 The American Chemical Society and American Chemical Society and American Society of Pharmacognosy

    Abstract

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    The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′-dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

    Copyright © 2008 The American Chemical Society and American Chemical Society and American Society of Pharmacognosy

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    Figure S1 and fractionation schemes. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2008, 71, 1, 102–105
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np070560c
    Published December 29, 2007
    Copyright © 2008 The American Chemical Society and American Chemical Society and American Society of Pharmacognosy

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