Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal PlantsClick to copy article linkArticle link copied!
- José C. Aponte
- Abraham J. Vaisberg
- Rosario Rojas
- Luz Caviedes
- Walter H. Lewis
- Gerardo Lamas
- César Sarasara
- Robert H. Gilman
- Gerald B. Hammond
Abstract
The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′-dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.
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