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Steroidal Saponins from Two Species of Dracaena
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    Steroidal Saponins from Two Species of Dracaena
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    Laboratoire de Pharmacognosie, Unité de Molécules d’Intérêt Biologique, UMIB UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7, Boulevard Jeanne d’Arc, BP 87900, 21079 Dijon Cedex, France, Laboratoire de Chimie des Substances Naturelles, Département de Chimie Organique, Faculté des Sciences, Université de Yaoundé I, BP 812 Yaoundé, Cameroon, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan, Universität Siegen, FB 8, OC-II (AK Ihmels), Adolf-Reichwein-Strasse 2, D-57068 Siegen, Germany, and Oncodesign, 20 Rue Jean Mazen, BP 27627, 21076 Dijon Cedex, France
    * To whom correspondence should be addressed. Tel: +33-3-80393229. Fax: +33-3-80393300. E-mail: [email protected]
    †Université de Bourgogne.
    ‡Université de Yaoundé I.
    §Kyushu University.
    ⊥Universität Siegen.
    ▽Oncodesign.
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2010, 73, 7, 1266–1270
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np100153m
    Published June 16, 2010
    Copyright © 2010 The American Chemical Society and American Society of Pharmacognosy

    Abstract

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    Four new steroidal saponins (14) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) from D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 14 were established as diosgenin 3-O-[3-O-sulfate-α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside (1), 1-O-β-d-xylopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-β-d-fucopyranosyl(23S,24S)-spirosta-5,25(27)-diene-1β,3β,23α,24α-tetrol 24-O-α-l-arabinopyranoside (2), pennogenin-3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-[6-O-acetyl]-β-d-glucopyranoside (3), and 24α-hydroxypennogenin 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.

    Copyright © 2010 The American Chemical Society and American Society of Pharmacognosy

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    1H NMR and 13C NMR spectra of compounds 14 and the results of the cytotoxicity of some compounds (Table 3) are available free of charge via the Internet at http://pubs.acs.org.

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2010, 73, 7, 1266–1270
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np100153m
    Published June 16, 2010
    Copyright © 2010 The American Chemical Society and American Society of Pharmacognosy

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