Steroidal Saponins from Two Species of DracaenaClick to copy article linkArticle link copied!
- Guy Beddos Kougan
- Tomofumi Miyamoto
- Chiaki Tanaka
- Thomas Paululat
- Jean-François Mirjolet
- Olivier Duchamp
- Beibam Lucas Sondengam
- Marie-Aleth Lacaille-Dubois
Abstract

Four new steroidal saponins (1−4) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) from D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 1−4 were established as diosgenin 3-O-[3-O-sulfate-α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranoside (1), 1-O-β-d-xylopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-β-d-fucopyranosyl(23S,24S)-spirosta-5,25(27)-diene-1β,3β,23α,24α-tetrol 24-O-α-l-arabinopyranoside (2), pennogenin-3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-[6-O-acetyl]-β-d-glucopyranoside (3), and 24α-hydroxypennogenin 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
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