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Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P−R from a Marine-Derived Fungus, Aspergillus sp.

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    Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P−R from a Marine-Derived Fungus, Aspergillus sp.
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    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan, Graduate School of Science, Chiba University, Inage-ku, Chiba 263-8522, Japan, and RIKEN Genomic Sciences Center (GSC), Tsurumi-ku, Yokohama 230-0045, Japan
    * To whom correspondence should be addressed. Tel: +81-96-371-4380. E-mail: [email protected]
    †Kumamoto University.
    ‡Chiba University.
    §RIKEN GSC. Current address: RIKEN Advanced Science Institute (ASI), 2-1 Hirosawa, Wako 351-0198, Japan.
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2010, 73, 8, 1438–1440
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    https://doi.org/10.1021/np1002498
    Published July 13, 2010
    Copyright © 2010 The American Chemical Society and American Society of Pharmacognosy
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    Abstract

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    Notoamides O−R were isolated from a marine-derived Aspergillus sp. Notoamide O possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids. The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway.

    Copyright © 2010 The American Chemical Society and American Society of Pharmacognosy

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    1D and 2D NMR and CD spectra of 1−4. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cite this: J. Nat. Prod. 2010, 73, 8, 1438–1440
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    Published July 13, 2010
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