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Total Synthesis and Structural Revision of (+)-Cristatumin C

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Departamento de Química Orgánica, Universidade de Vigo, Lagoas-Marcosende, 36310 Vigo, Spain
*Tel: +34-986-812316. Fax: +34-986-818622. E-mail: [email protected] (Á. de Lera).
Cite this: J. Nat. Prod. 2014, 77, 2, 421–423
Publication Date (Web):January 17, 2014
https://doi.org/10.1021/np400969u
Copyright © 2014 The American Chemical Society and American Society of Pharmacognosy

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    Abstract

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    Naturally occurring (+)-cristatumin C, a bis-pyrrolidinoindoline diketopiperazine alkaloid isolated from Eurotium cristatum EN-220, is the 2R,3R,11S,15R,2′R,3′R,11′S,15′S enantiomer, as confirmed by total synthesis.

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    Comparison of the NMR data of natural and synthetic cristatumin C, spectroscopic data for homodimers 12 and 13, and copies of 1H NMR and 13C NMR spectra. This material is available free of charge via the Internet at http://pubs.acs.org.

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    16. John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro, Michèle R. Prinsep. Marine natural products. Natural Product Reports 2016, 33 (3) , 382-431. https://doi.org/10.1039/C5NP00156K
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