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Chemical Composition of the Bark of Tetrapterys mucronata and Identification of Acetylcholinesterase Inhibitory Constituents

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    Chemical Composition of the Bark of Tetrapterys mucronata and Identification of Acetylcholinesterase Inhibitory Constituents
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    † Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, NuBBE, Instituto de Química, Universidade Estadual Paulista (UNESP), Araraquara, São Paulo, Brazil
    ‡ School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 30, Quai Ernest-Ansermet, CH-1211, Geneva 4, Switzerland
    § Division of Pharmaceutical Biology, University of Basel, Klingelbergrstrasse 50, CH-4056, Basel, Switzerland
    *Tel: ++ 41 22 379 3641. Fax: ++41 22 379 33 99. E-mail: [email protected]
    *Tel: ++55 16 3301 9660. Fax: ++55 16 3322 2308. E-mail: [email protected]
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2014, 77, 3, 650–656
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    https://doi.org/10.1021/np401003p
    Published February 12, 2014
    Copyright © 2014 The American Chemical Society and American Society of Pharmacognosy
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    Abstract

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    The secondary metabolite content of Tetrapterys mucronata, a poorly studied plant that is used occasionally in Brazil for the preparation of a psychotropic plant decoction called “Ayahuasca”, was determined to establish its chemical composition and to search for acetylcholinesterase (AChE) inhibitors. The ethanolic extract of the bark of T. mucronata exhibited in vitro AChE inhibition in a TLC bioautography assay. To localize the active compounds, biological profiling for AChE inhibition was performed using at-line HPLC-microfractionation in 96-well plates and subsequent AChE inhibition bioautography. The analytical HPLC-PDA conditions were transferred geometrically to a preparative medium-pressure liquid chromatography column using chromatographic calculations for the efficient isolation of the active compounds at the milligram scale. Twenty-two compounds were isolated, of which six are new natural products. The structures of the new compounds (9, 10, 16–18, and 20) were elucidated by spectroscopic data interpretation. Compounds 1, 5, 6, 9, and 10 inhibited AChE with IC50 values below 15 μM.

    Copyright © 2014 The American Chemical Society and American Society of Pharmacognosy

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 2014, 77, 3, 650–656
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np401003p
    Published February 12, 2014
    Copyright © 2014 The American Chemical Society and American Society of Pharmacognosy
    Request reuse permissions

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