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Halicylindramides D and E, Antifungal Peptides from the Marine Sponge Halichondria cylindrata

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    Halicylindramides D and E, Antifungal Peptides from the Marine Sponge Halichondria cylindrata 1
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    Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agriculture and Agricultural Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
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    Journal of Natural Products

    Cite this: J. Nat. Prod. 1996, 59, 2, 163–166
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    https://doi.org/10.1021/np9600309
    Published February 22, 1996
    Copyright © 1996 American Chemical Society and American Society of Pharmacognosy
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    Abstract

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    Halicylindramides D (1) and E (2) have been isolated from the marine sponge Halichondria cylindrata. Halicylindramide D is a tridecapeptide with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue, while halicylindramide E is a truncated linear peptide with a C-terminal amide. Their structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Halicylindramide D was antifungal against Mortierella ramanniana and cytotoxic against P-388 murine leukemia cells.

    Copyright © 1996 American Chemical Society and American Society of Pharmacognosy

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     Abstract published in Advance ACS Abstracts, January 1, 1996.

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    Journal of Natural Products

    Cite this: J. Nat. Prod. 1996, 59, 2, 163–166
    Click to copy citationCitation copied!
    https://doi.org/10.1021/np9600309
    Published February 22, 1996
    Copyright © 1996 American Chemical Society and American Society of Pharmacognosy
    Request reuse permissions

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