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Direct Synthesis of Arylketones by Nickel-Catalyzed Addition of Arylboronic Acids to Nitriles

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Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan
Cite this: Org. Lett. 2010, 12, 8, 1736–1739
Publication Date (Web):March 24, 2010
Copyright © 2010 American Chemical Society

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A convenient and efficient method for the synthesis of various arylketones by nickel-catalyzed addition of arylboronic acids to nitriles is described. A catalytic cycle involving Ni(II) species as the catalytic intermediates is proposed to account for the present catalytic reaction.

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