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An Asymmetric Hydrogenation Route To (−)-Spongidepsin

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Texas A & M University, Chemistry Department, P.O. Box 30012, College Station, Texas 77842
Cite this: Org. Lett. 2010, 12, 19, 4392–4395
Publication Date (Web):September 7, 2010
https://doi.org/10.1021/ol1018773
Copyright © 2010 American Chemical Society

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    Abstract

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    (−)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to give several spongidepsin analogues, and their cytotoxicities were compared with those of the natural product.

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    Experimental procedures and characterization data for the new compounds reported. This material is available free of charge via the Internet at http://pubs.acs.org.

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