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Polyisocyanides As a New Alignment Medium To Measure Residual Dipolar Couplings for Small Organic Molecules

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Institute for Analytical Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany
[email protected]
Cite this: Org. Lett. 2012, 14, 1, 241–243
Publication Date (Web):December 13, 2011
https://doi.org/10.1021/ol202547y
Copyright © 2011 American Chemical Society
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    Abstract

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    Polyisocycanides were found to give anisotropic molecular alignment in the magnetic field and are useful to measure residual dipolar couplings (RDCs) from analytes, e.g. strychnine. They show less quadrupolar splitting of the deuterated solvent signal compared with other liquid crystal systems such as Poly-γ-benzyl-l-glutamate (PBLG) and hence less undesired line broadening.

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