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Palladium-Catalyzed N-Arylation of 2-Aminothiazoles

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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
Cite this: Org. Lett. 2012, 14, 6, 1432–1435
Publication Date (Web):March 6, 2012
Copyright © 2012 American Chemical Society

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    A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.

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