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Copper-Catalyzed Alkylation of Benzoxazoles with Secondary Alkyl Halides

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Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland
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Cite this: Org. Lett. 2012, 14, 7, 1748–1751
Publication Date (Web):March 9, 2012
https://doi.org/10.1021/ol300348w
Copyright © 2012 American Chemical Society
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Abstract

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Copper-catalyzed direct alkylation of benzoxazoles using nonactivated secondary alkyl halides has been developed. The best catalyst is a new copper(I) complex (1), and the reactions are promoted by bis[2-(N,N-dimethylamino)ethyl] ether.

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