A Novel Sperm-Activating and Attracting Factor from the Ascidian Ascidia sydneiensis
- Nobuaki Matsumori ,
- Yuki Hiradate ,
- Hajime Shibata ,
- Tohru Oishi ,
- Shuichi Shimma ,
- Michisato Toyoda ,
- Fumiaki Hayashi ,
- Manabu Yoshida ,
- Michio Murata , and
- Masaaki Morisawa
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Department of Chemistry and Department of Physics, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan, Department of Biology, Faculty of Science, Yamagata University, Kojirakawa, Yamagata 990-8560, Japan, Misaki Marine Biological Station, Graduate School of Science, University of Tokyo, Miura, Kanagawa 238-0225, Japan, Department of Chemistry, Graduate School of Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan, and RIKEN Systems and Structural Biology Center, RIKEN Yokohama Institute, Yokohama, Kanagawa, 230-0045, Japan
†Department of Chemistry, Osaka University.
‡Department of Biology, Yamagata University.
§Misaki Marine Biological Station, University of Tokyo.
∥Department of Chemistry, Kyushu University.
⊥Department of Physics, Osaka University.
#RIKEN Systems and Structural Biology Center, RIKEN Yokohama Institute.
&Present address: Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai, Miyagi 981-8555, Japan.
@Present address: National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
̂Present address: Project Research Center for Fundamental Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan,
$Present address: Tokyo Kasei Gakuin University, Machida, Tokyo 194-0292, Japan.
△These authors contributed equally to this work.
Abstract
A novel SAAF was isolated from the title ascidian. The structure was elucidated using the entire sample of 4 nmol, suggesting that the position of the OH group confers genus-specificity to sperm chemotaxis in ascidians. This study not only provides insight into the chemical tactics in sperm chemotaxis but demonstrates that the innovative techniques allow structure determination of natural products in trace amounts.
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