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Two New Quinochalcones from the Florets of Carthamus tinctorius

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Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People’s Republic of China
* To whom correspondence should be addressed. Phone: 86-10-63165231. Fax: 86-10-63017757. [email protected]
Cite this: Org. Lett. 2010, 12, 6, 1196–1199
Publication Date (Web):February 19, 2010
Copyright © 2010 American Chemical Society

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Two new quinochalcone compounds, named saffloquinoside A (1) and saffloquinoside B (2), were isolated from the florets of Carthamus tinctorius. Their unusual structures including their absolute stereochemistry were elucidated based on UV, IR, HRESIMS, 1D and 2D NMR data, and CD spectrum. Saffloquinoside A has an uncommon six−five member dioxaspirocycle and saffloquinoside B has a cyclohexatrione skeleton with a benzyl group and two C-glycosyl units. Saffloquinoside A exhibited middling anti-inflammatory activity.

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MS, HRMS, IR, UV, 1D and 2D NMR, and CD spectra of compounds 1 and 2. This material is available free of charge via the Internet at

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