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Racemo-Selective Synthesis of ansa-Zirconocene Derivates from Zirconium Biphenolate Complexes

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    Racemo-Selective Synthesis of ansa-Zirconocene Derivates from Zirconium Biphenolate Complexes
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    Fakultät für Chemie, Universität Konstanz, D-78457 Konstanz, Germany
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    Organometallics

    Cite this: Organometallics 2001, 20, 25, 5258–5265
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    https://doi.org/10.1021/om010605j
    Published November 8, 2001
    Copyright © 2001 American Chemical Society
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    Abstract

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    Stereoselective reactions of zirconium biphenolate complexes of the general formula (BIP)ZrCl2(THF)2 (1a−c), where BIP = 3,3‘-iPr2-6,6‘-Me2-1,1‘-bi-2-phenolate (a), 3,3‘-tBu2-5,5‘-Me2-1,1‘-bi-2-phenolate (b), or 3,3‘,5,5‘-tBu4-1,1‘-bi-2-phenolate (c), with 1 equiv of the lithium or magnesium salts of various ansa-bis(indenyl) ligands give the ansa-zirconocenes rac-C2H4(Ind)2Zr(BIP) (2b), rac-Me2Si(Ind)2Zr(BIP) (3c), rac-Me2Si(2-Me-Ind)2Zr(BIP) (4c), rac-Me2Si(2-Me-4-Ph-Ind)2Zr(BIP) (5c), and rac-Me2Si(2-Me-Benz[e]Ind)2Zr(BIP) (6c) in isolated yields of 60−75%. Reactions of C2H4(Ind)2Mg(THF)2 with 1a and 1b and of Me2Si(Ind)2Li2 with 1c give directly the pure diastereomers rac-2a, rac-2b, and rac-3c, respectively. More highly substituted indenyl ligands, on the other hand, give initially kinetically controlled mixtures of the rac- and meso-zirconocene BIP derivatives 4c, 5c, and 6c, from which the pure rac-derivatives are obtained as thermodynamically favored products by heating the reaction mixtures to 75 °C for 5−7 h. The meso-to-rac isomerization of 6c is catalyzed by addition of TEMPO and is thus likely to occur by way of radical intermediates. Crystal and molecular structures of 1b and 2b and of 1c and 6c indicate that formation of the racemo diastereomers is favored by repulsive interactions between biphenolate and ansa-bis(indenyl) ligands.

    Copyright © 2001 American Chemical Society

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    Details of crystal structure determinations, atomic coordinates, isotropic and anisotropic displacement parameters, and bond lengths and angles of complexes 1b, 1c, 2b, and 6c. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cited By

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    Organometallics

    Cite this: Organometallics 2001, 20, 25, 5258–5265
    Click to copy citationCitation copied!
    https://doi.org/10.1021/om010605j
    Published November 8, 2001
    Copyright © 2001 American Chemical Society
    Request reuse permissions

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