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Mono- and 1,1′-Disubstituted Organoruthenium Cyclopentadiene Complexes: Synthesis, Structural Characterization, and Antitumoral Evaluation

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    Mono- and 1,1′-Disubstituted Organoruthenium Cyclopentadiene Complexes: Synthesis, Structural Characterization, and Antitumoral Evaluation
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    † Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
    ‡ Drug Discovery Group, Queensland Institute of Medical Research, Brisbane, Australia
    *Tel: +61 07 373 57728. E-mail: [email protected]
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    Organometallics

    Cite this: Organometallics 2011, 30, 6, 1395–1403
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    https://doi.org/10.1021/om100928s
    Published March 1, 2011
    Copyright © 2011 American Chemical Society
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    Abstract

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    This article outlines the synthesis and characterization of a structurally diverse range of mono- and 1,1′-disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel−Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(η5-C5H5)(η5-C5H4CO)]2O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these organoruthenium metallocenes to possess moderate to weak cytotoxicity toward cancerous cells.

    Copyright © 2011 American Chemical Society

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    Crystallographic data (including cif files) for compound 11 (CCDC 794550). This material is available free of charge via the Internet at http://pubs.acs.org.

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    This article is cited by 16 publications.

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    Organometallics

    Cite this: Organometallics 2011, 30, 6, 1395–1403
    Click to copy citationCitation copied!
    https://doi.org/10.1021/om100928s
    Published March 1, 2011
    Copyright © 2011 American Chemical Society
    Request reuse permissions

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