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    The Merck Bile Acid Cortisone Process:  The Next-to-Last Word
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    Organic Process Research & Development

    Cite this: Org. Proc. Res. Dev. 2004, 8, 5, 708–724
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    https://doi.org/10.1021/op030050z
    Published April 15, 2004
    Copyright © 2004 American Chemical Society
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    Abstract

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    A personal account of the process research and development effort at Merck and Company, leading to the first commercial process for the manufacture of cortisone acetate, is described.

    Copyright © 2004 American Chemical Society

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     Merck and Company, Inc., Process Research and Development, Retired.

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    This article is cited by 29 publications.

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    17. Kieran D. Jones, Scott G. Stewart. Recent Advances in Steroid Synthesis: A Tribute to Sir Derek Barton. Australian Journal of Chemistry 2018, 71 (9) , 627. https://doi.org/10.1071/CH18256
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    20. H.-J. Federsel. 9.2 Asymmetry in the Plant: Concepts and Principles for the Scale-Up of Asymmetric Organic Reactions. 2012, 27-45. https://doi.org/10.1016/B978-0-08-095167-6.00902-2
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    22. Peter J. Dunn. The importance of Green Chemistry in Process Research and Development. Chem. Soc. Rev. 2012, 41 (4) , 1452-1461. https://doi.org/10.1039/C1CS15041C
    23. . Miescher Degradation. 2010, 1940-1944. https://doi.org/10.1002/9780470638859.conrr435
    24. . Wohl‐Ziegler Bromination. 2010, 3067-3072. https://doi.org/10.1002/9780470638859.conrr680
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    27. H.-J. Federsel. Chiral Drug Discovery and Development – From Concept Stage to Market Launch. 2007, 713-736. https://doi.org/10.1016/B0-08-045044-X/00054-7
    28. Bernd Schäfer. Hormone. 2006, 337-392. https://doi.org/10.1007/978-3-662-61017-6_6
    29. James R. Hanson. Steroids: partial synthesis in medicinal chemistry. Nat. Prod. Rep. 2006, 23 (1) , 100-107. https://doi.org/10.1039/B512848J
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    Cite this: Org. Proc. Res. Dev. 2004, 8, 5, 708–724
    Click to copy citationCitation copied!
    https://doi.org/10.1021/op030050z
    Published April 15, 2004
    Copyright © 2004 American Chemical Society
    Request reuse permissions

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